The protective effect of carnosic acid on dextran sulfate sodium-induced colitis based on metabolomics and gut microbiota analysis

Accumulating evidence suggests that the gut microbiota plays an important role in the pathogenesis of inflammatory bowel disease(IBD).Carnosic acid(CA)is a major antioxidant component of rosemary and sage.Herein,we investigated the protective effects of dietary CA on dextran sodium sulfate(DSS)-induced colitis mouse model with an emphasis on its impact on the composition and metabolic function of gut microbiota.We found that CA effectively attenuated DSS-stimulated colitis in mice,as evidenced by reduced disease activity index(DAI),and systemic and colonic inflammation.Additionally,CA restored microbial diversity and improved the composition of gut microbiota in DSS-treated mice.Moreover,Spearman’s correlation coefficient showed a significant correlation between the fecal metabolites and the gut microbiota species.Changes in gut microbiota and the correlated metabolites might partially explain CA’s anti-inflammatory effects against colitis.Future clinical trials are needed to determine the therapeutic effects and mechanisms of CA on IBD in humans.

Study of the Interception Scheme Based on A* Path Finding Algorithm in Computer Game

In the game, we generally use A* algorithm for pathfinding according to the target location and map information to realize the tracking and interception task. This approach is simple to implement, but is often less than ideal in its presentation, because it does not allow game units to predictably choose paths based on dynamic targets or obstacles, and may lead to blocked channels or difficulty in choosing the actual optimal path. This paper focuses on analyzing the need of a unit when intercepting another unit in the game, and make an interception scheme which can adapt itself to dynamic obstacles and moving target thus presents artificial intelligence to some extent.

Rhein-based Pickering emulsion for hepatocellular carcinoma:Shaping the metabolic signaling and immunoactivation in transarterial chemoembolization

The efficacy of transarterial chemoembolization(TACE)has been limited by insufficient embolization and a high incidence of tumor recurrence.Herein,we iden-tified that aberrant metabolic reprogramming and immunosuppression contribute to TACE refractoriness and Rhein,as a potential glycolytic metabolism inhibitor and immunoactivation inducer,was optimized to sensitize tumors to TACE therapy.To achieve efficient embolization,we developed an oil-in-water lipiodol embolic emulsion by stabilizing the self-assembled Rhein nanogel.The assembled Rhein exhibited a nanofiber network,and its integration enhanced the mechanical stability and viscoelasticity of the lipiodol embolic agent.With the synergistic advantages of solid and liquid embolic agents,this carrier-free Pickering emulsion exhibits effi-cient embolization and sustained drug release in models of unilateral renal artery embolization,rabbit ear tumor embolization,rabbit orthotopic liver cancer,and rat orthotopic liver cancer.Compared to conventional three-way catheter mixing meth-ods,multimodal imaging corroborates a marked enhancement in local drug retention and tumor suppression.Importantly,the incorporation of Rhein-mediated syner-gistic immunoembolization in this strategy achieved efficient embolization while robustly activating anti-tumor immune responses,including inducing immunogenic cell death,dendritic cell activation,and major histocompatibility complex class I pre-sentation to CD8+T cells for tumor killing.Together,thesefindings reveal a novel strategy for the application of self-assembled Rhein nanofiber-stabilized lipiodol emulsion to control metabolic signaling and immunoactivation in TACE.

A radial symmetry and Liouville theorem for systems involving fractional Laplacian

We investigate the nonnegative solutions of the system involving the fractional Laplacian：{（-△）^αui（x）=fi（u）,x∈R^n,i=1,2,…,m, u（x）=（u1（x）,u2（x）,……,um（x））,where 0 〈 α 〈 1, n 〉 2, fi（u）, 1 4 ≤ 4 ≤m, are real-valued nonnegative functions of homogeneous degree Pi ≥0 and nondecreasing with respect to the independent variables ul, u2,..., urn. By the method of moving planes, we show that under the above conditions, all the positive solutions are radially symmetric and monotone decreasing about some point x0 if Pi = （n ＋ 2α）/（n- 2α） for each 1 ≤ i ≤ m; and the only nonnegative solution of this system is u ≡ 0 if 1〈pi〈（n＋2α）/（n-2α） for all 1≤i≤m.

锂离子电池硅纳米粒子/碳复合材料

硅由于其超高的理论比容量有望取代石墨成为下一代锂离子电池负极材料,但是硅在充放电过程中巨大的体积膨胀(～300%)会导致材料粉化从集流体上脱落,同时不断形成固相电解质层,造成不可逆容量损失,而材料纳米化和碳复合是解决这些问题的有效手段。本文介绍了硅在循环过程中容量衰减机理,并综述了硅纳米粒子与碳材料复合的最新进展,主要包括包覆型、核壳型以及嵌入型硅碳负极材料,并对核壳型与嵌入型做了重点探究,最后对硅纳米粒子/碳复合材料存在的问题进行分析并展望其研究前景。

Conversion therapy of intermediate and advanced hepatocellular carcinoma using superstable homogeneous iodinated formulation technology

Interventional embolization is one of the most common treatment strategies in the clinical cancer treatment,especially in liver cancer(Sieghart et al.,2015).However,unstable dispersion and rapid drug release are the bottlenecks in clinical practice.The superstable homogeneous iodinated formulation technology(SHIFT)in interventional embolization treatment has achieved homogeneous dispersion of drugs in lipiodol embolic agent,showing promising clinical translation prospects(Chen et al.,2020 a;He et al.,2022 a.