In order to examine the biaxial compression-compression properties of rubber fibre reinforced concrete(RFRC),an experimental study on RFRC under different lateral compressive stresses was carried out by considering di...In order to examine the biaxial compression-compression properties of rubber fibre reinforced concrete(RFRC),an experimental study on RFRC under different lateral compressive stresses was carried out by considering different rubber replacement rates and polypropylene fibre contents.The failure modes and mechanical property parameters of different RFRC working conditions were obtained from the experiment to explore the effects of rubber replacement rate and polypropylene fibre content on the biaxial compression-compression properties of RFRC.The following conclusions were drawn.Under the influence of lateral compressive stress,the biaxial compression-compression failure mode gradually developed from a columnar pattern to a flaky pattern,suggesting that the incorporation of rubber and polypropylene fibres into the concrete resulted in a significant change in the development of cracks.For different rubber replacement rates and polypropylene fibre contents,the vertical compressive stress exhibited the same developing trend under the influence of lateral compressive stress.Specifically,the lateral compressive stress imposed the minimum effect on the vertical compressive stress when the rubber replacement rate and polypropylene fibre content were 20%and 0.4%,respectively,and imposed the maximum effect when the rubber replacement rate and polypropylene fibre content were 20%and 0%,respectively.With the increase of rubber replacement rate,the vertical peak stress was significantly reduced,which implies that an appropriate amount of polypropylene fibres can increase the vertical peak stress to a certain extent.Then,the biaxial compression-compression mechanism of RFRC was analysed from the microscopic level by using scanning electron microscope(SEM).Meanwhile,based on Kupfer’s biaxial compression-compression failure criterion and the octahedral stress space,a biaxial compression-compression failure criterion for RFRC was proposed,which was proven to have good applicability.The research results of this study provide important theoretical basis for the engineering application and development of RFRC.展开更多
Extreme longevity has evolved multiple times during the evolution of mammals,yet its underlying molecular mechanisms remain largely underexplored.Here,we compared the evolution of 115 aging-related genes in 11 long-li...Extreme longevity has evolved multiple times during the evolution of mammals,yet its underlying molecular mechanisms remain largely underexplored.Here,we compared the evolution of 115 aging-related genes in 11 long-lived species and 25 mammals with non-increased lifespan(control group)in the hopes of better understanding the common molecular mechanisms behind longevity.We identified 16 unique positively selected genes and 23 rapidly evolving genes in long-lived species,which included nine genes involved in regulating lifespan through the insulin/IGF-1 signaling(IIS)pathway and 11 genes highly enriched in immune-response-related pathways,suggesting that the IIS pathway and immune response play a particularly important role in exceptional mammalian longevity.Interestingly,11 genes related to cancer progression,including four positively selected genes and seven genes with convergent amino acid changes,were shared by two or more long-lived lineages,indicating that long-lived mammals might have evolved convergent or similar mechanisms of cancer resistance that extended their lifespan.This suggestion was further corroborated by our identifi-cation of 12 robust candidates for longevity-related genes closely related to cancer.展开更多
基金supported by the National 12th Five Year Plan of Science and Technology Support Project(2015 BAL02b02)National Spark Plan Project(2015 GA690045),Jiangsu Province“Six Talent Peaks”Team Project(XCL-CXTD−007).
文摘In order to examine the biaxial compression-compression properties of rubber fibre reinforced concrete(RFRC),an experimental study on RFRC under different lateral compressive stresses was carried out by considering different rubber replacement rates and polypropylene fibre contents.The failure modes and mechanical property parameters of different RFRC working conditions were obtained from the experiment to explore the effects of rubber replacement rate and polypropylene fibre content on the biaxial compression-compression properties of RFRC.The following conclusions were drawn.Under the influence of lateral compressive stress,the biaxial compression-compression failure mode gradually developed from a columnar pattern to a flaky pattern,suggesting that the incorporation of rubber and polypropylene fibres into the concrete resulted in a significant change in the development of cracks.For different rubber replacement rates and polypropylene fibre contents,the vertical compressive stress exhibited the same developing trend under the influence of lateral compressive stress.Specifically,the lateral compressive stress imposed the minimum effect on the vertical compressive stress when the rubber replacement rate and polypropylene fibre content were 20%and 0.4%,respectively,and imposed the maximum effect when the rubber replacement rate and polypropylene fibre content were 20%and 0%,respectively.With the increase of rubber replacement rate,the vertical peak stress was significantly reduced,which implies that an appropriate amount of polypropylene fibres can increase the vertical peak stress to a certain extent.Then,the biaxial compression-compression mechanism of RFRC was analysed from the microscopic level by using scanning electron microscope(SEM).Meanwhile,based on Kupfer’s biaxial compression-compression failure criterion and the octahedral stress space,a biaxial compression-compression failure criterion for RFRC was proposed,which was proven to have good applicability.The research results of this study provide important theoretical basis for the engineering application and development of RFRC.
基金This study was supported by the National Natural Science Foundation of China(NSFC,grant nos.32070409,31772448 to S.X.,31872219 to W.R.)the Key Project of the NSFC(grant nos.32030011,31630071 to G.Y.)+1 种基金National Key Programme of Research and Development of China,Ministry of Science and Technology(grant no.2016YFC0503200 to G.Y.and S.X.)the Priority Academic Program Development of Jiangsu Higher Education Institutions to G.Y.and S.X.,and the Qinglan project of Jiangsu Province to S.X.These funding bodies played no role in study design,data collection,analysis,interpretation of data,and writing the manuscript.We are particularly grateful to Dr.Yan-bo Sun(Yunnan University,Kunming,Yunnan,China)for the suggestion of data analysis.Many thanks are also given to Zepeng Zhang,Simin Chai,Yuan Mu,and Weijian Guo for support and discussions.
文摘Extreme longevity has evolved multiple times during the evolution of mammals,yet its underlying molecular mechanisms remain largely underexplored.Here,we compared the evolution of 115 aging-related genes in 11 long-lived species and 25 mammals with non-increased lifespan(control group)in the hopes of better understanding the common molecular mechanisms behind longevity.We identified 16 unique positively selected genes and 23 rapidly evolving genes in long-lived species,which included nine genes involved in regulating lifespan through the insulin/IGF-1 signaling(IIS)pathway and 11 genes highly enriched in immune-response-related pathways,suggesting that the IIS pathway and immune response play a particularly important role in exceptional mammalian longevity.Interestingly,11 genes related to cancer progression,including four positively selected genes and seven genes with convergent amino acid changes,were shared by two or more long-lived lineages,indicating that long-lived mammals might have evolved convergent or similar mechanisms of cancer resistance that extended their lifespan.This suggestion was further corroborated by our identifi-cation of 12 robust candidates for longevity-related genes closely related to cancer.