The compositions of the secondary structures of protein in the human breast normal, hyperplasia, fibroadenoma and invasive ductal carcinoma tissues have been estimated from the Fourier self deconvolved spectra, the se...The compositions of the secondary structures of protein in the human breast normal, hyperplasia, fibroadenoma and invasive ductal carcinoma tissues have been estimated from the Fourier self deconvolved spectra, the second derivative spectra and the curve-fitting analysis of the amide I bands in their spectra. Some parameters of the secondary structures of proteins in these 4 types of tissues are significantly different and located in separate ranges.展开更多
Some remarkable FTIR spectral differences are observed and the differences at the molecular level are extracted between benign and malignant breast tissue samples. For the malignant tissue, the relative content of nuc...Some remarkable FTIR spectral differences are observed and the differences at the molecular level are extracted between benign and malignant breast tissue samples. For the malignant tissue, the relative content of nucleic acids is increased whereas the collagen is decreased. The proteins are phosphorylated and become more flexible and disordered. And these significant differences have important implications not only for probing the process of the breast lesion at the molecular level, but also for evaluating the histological types and grades of breast diseases.展开更多
文摘The compositions of the secondary structures of protein in the human breast normal, hyperplasia, fibroadenoma and invasive ductal carcinoma tissues have been estimated from the Fourier self deconvolved spectra, the second derivative spectra and the curve-fitting analysis of the amide I bands in their spectra. Some parameters of the secondary structures of proteins in these 4 types of tissues are significantly different and located in separate ranges.
文摘Some remarkable FTIR spectral differences are observed and the differences at the molecular level are extracted between benign and malignant breast tissue samples. For the malignant tissue, the relative content of nucleic acids is increased whereas the collagen is decreased. The proteins are phosphorylated and become more flexible and disordered. And these significant differences have important implications not only for probing the process of the breast lesion at the molecular level, but also for evaluating the histological types and grades of breast diseases.
