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Clinical treatment procedure and experience of six gene-edited pigrhesus monkey heterotopic heart xenotransplantation
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作者 Bing Zhang Pengfei Ji +13 位作者 Langang Peng Mengen Zhai Jiayou Tang Lin Zhao Yan jin Baoling Xu Xiangni Lyu Linhe Lu Yenong Zhou zhenxiao jin Weixun Duan Xiuling Yang Wei Yi jincheng Liu 《Chinese Medical Journal》 SCIE CAS CSCD 2024年第8期997-999,共3页
Heart transplantation is an effective treatment for endstage heart failure;however,problems such as the severe shortage of donor hearts,rejection,the toxic effects of immunosuppressants,and serious postoperative compl... Heart transplantation is an effective treatment for endstage heart failure;however,problems such as the severe shortage of donor hearts,rejection,the toxic effects of immunosuppressants,and serious postoperative complications remain.[1]Heart xenotransplantation is one of the most promising alternatives to address the shortage of allogeneic donor hearts.However,the recipient survival rate and quality of life are affected by major obstacles,including immune rejection,complement and coagulation dysfunction,and infection.[2,3]Owing to the continuous improvement of gene editing strategies for donor pigs and anti-immune rejection strategies for non-human primate recipients. 展开更多
关键词 DONOR treatment SHORTAGE
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Expert consensus on the use of human serum albumin in adult cardiac surgery 被引量:3
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作者 Fei Xiang Fuhua Huang +25 位作者 Jiapeng Huang Xin Li Nianguo Dong Yingbin Xiao Qiang Zhao Liqiong Xiao Haitao Zhang CuiZhang Zhaoyun Cheng Liangwan Chen Jimei Chen Huishan Wang Yingqiang Guo Nan Liu Zhe Luo Xiaotong Hou Bingyang Ji Rong Zhao zhenxiao jin Robert Savage Yang Zhao Zhe Zheng Xin Chen on behalf of Chinese Association of Cardiovascular Surgeons Chinese Society of Thoracic and Cardiovascular Surgery Chinese Society of Cardiothoracic and Vascular Anesthesiology 《Chinese Medical Journal》 SCIE CAS CSCD 2023年第10期1135-1143,共9页
Introduction Albumin,which is a 65-kDa liver-synthesized protein,accounts for nearly 50%of total plasma protein and contributes to approximately 80%of intravascular oncotic pressure.Albumin helps maintain microvascula... Introduction Albumin,which is a 65-kDa liver-synthesized protein,accounts for nearly 50%of total plasma protein and contributes to approximately 80%of intravascular oncotic pressure.Albumin helps maintain microvascular integrity,functions as an antioxidant,and transports hormones,fatty acid,bile salts,bilirubin,electrolytes(e.g.,calcium,magnesium,copper,zinc,et al.),and drugs.[1–3]Human serum albumin(HSA)is a sterile,liquid albumin product derived from large pools of human plasma by fractionation and pasteurization.The medical use of HAS could date back to approximately the time of World War II. 展开更多
关键词 ALBUMIN DRUGS SURGERY
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