Harnessing AI-human synergy for deep learning research analysis in ophthalmology with large language models assisting humans

Background:Research innovations inocular disease screening,diagnosis,and management have been boosted by deep learning(DL)in the last decade.To assess historical research trends and current advances,we conducted an artificial intelligence(AI)-human hybrid analysis of publications on DL in ophthalmology.Methods:All DL-related articles in ophthalmology,which were published between 2012 and 2022 from Web of Science,were included.500 high-impact articles annotated with key research information were used to fine-tune a large language models(LLM)for reviewing medical literature and extracting information.After verifying the LLM's accuracy in extracting diseases and imaging modalities,we analyzed trend of DL in ophthalmology with 2535 articles.Results:Researchers using LLM for literature analysis were 70%(P=0.0001)faster than those who did not,while achieving comparable accuracy(97%versus 98%,P=0.7681).The field of DL in ophthalmology has grown 116%annually,paralleling trends of the broader DL domain.The publications focused mainly on diabetic retinopathy(P=0.0003),glaucoma(P=0.0011),and age-related macular diseases(P=0.0001)using retinal fundus photographs(FP,P=0.0015)and optical coherence tomography(OCT,P=0.0001).DL studies utilizing multimodal images have been growing,with FP and OCT combined being the most frequent.Among the 500 high-impact articles,laboratory studies constituted the majority at 65.3%.Notably,a discernible decline in model accuracy was observed when categorizing by study design,notwithstanding its statistical insignificance.Furthermore,43 publicly available ocular image datasets were summarized.Conclusion:This study has characterized the landscape of publications on DL in ophthalmology,by identifying the trends and breakthroughs among research topics and the fast-growing areas.This study provides an efficient framework for combined AI-human analysis to comprehensively assess the current status and future trends in the field.

The national multi-center artificial intelligent myopia prevention and control project

In recent years,the incidence of myopia has increased at an alarming rate among children and adolescents in China.The exploration of an effective prevention and control method for myopia is in urgent need.With the development of information technology in the past decade,artificial intelligence with the Internet of Things technology(AIoT)is characterized by strong computing power,advanced algorithm,continuous monitoring,and accurate prediction of long-term progression.Therefore,big data and artificial intelligence technology have the potential to be applied to data mining of myopia etiology and prediction of myopia occurrence and development.More recently,there has been a growing recognition that myopia study involving AIoT needs to undergo a rigorous evaluation to demonstrate robust results.