A series of furoxan-based novel nitric oxide-donating ursolic acid（UA） derivatives（7a-f） were synthesized,and their cytotoxic activities against HepG2 cells in vitro were evaluated by MTT method.It was found that ...A series of furoxan-based novel nitric oxide-donating ursolic acid（UA） derivatives（7a-f） were synthesized,and their cytotoxic activities against HepG2 cells in vitro were evaluated by MTT method.It was found that 7a-d and 7f showed more potent cytotoxic activities than control 5-fluorouracil and UA.展开更多
基金supported by a grant from the National Natural Science Foundation of China(No.2097210)research grants from the Natural Science Foundation of Jiangsu Province(No.BK2009302)Tianjin Application Bases and Advanced Technology Research Program Key Projects(No.JCZDJC21400)
文摘A series of furoxan-based novel nitric oxide-donating ursolic acid（UA） derivatives（7a-f） were synthesized,and their cytotoxic activities against HepG2 cells in vitro were evaluated by MTT method.It was found that 7a-d and 7f showed more potent cytotoxic activities than control 5-fluorouracil and UA.
