A new product PEGylated rhaFGF was obtained by site-directed chemical modification.When compared with unmodified rhaFGF, PEGylated rhaFGF showed comparable bioactivity and superior stability at 37℃ in mouse serum and...A new product PEGylated rhaFGF was obtained by site-directed chemical modification.When compared with unmodified rhaFGF, PEGylated rhaFGF showed comparable bioactivity and superior stability at 37℃ in mouse serum and the stronger resistant potency to trypsin. This was accompanied by a substantial decreasing tmmunogenicity.Site-specific PEGylation of rhaFGF may increase its therapeutic potency in humans.展开更多
基金The Hi-tech Research and Development Program of China(2002AA2Z3318)Guangdong Natural Science Foundation(010424)supported this study.
文摘A new product PEGylated rhaFGF was obtained by site-directed chemical modification.When compared with unmodified rhaFGF, PEGylated rhaFGF showed comparable bioactivity and superior stability at 37℃ in mouse serum and the stronger resistant potency to trypsin. This was accompanied by a substantial decreasing tmmunogenicity.Site-specific PEGylation of rhaFGF may increase its therapeutic potency in humans.
