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Cathelicidin a potential therapeutic peptide for gastrointestinal inflammation and cancer 被引量:1
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作者 Jimmy Yip Chuen Chow zhi jie li +1 位作者 William Ka Kei Chi Hin Cho 《World Journal of Gastroenterology》 SCIE CAS 2013年第18期2731-2735,共5页
Cathelicidins, are host defense peptides synthesized and stored in circulating leukocytes and numerous types of epithelial tissues in particular the gastrointestinal (GI) tract and skin. They have been known for their... Cathelicidins, are host defense peptides synthesized and stored in circulating leukocytes and numerous types of epithelial tissues in particular the gastrointestinal (GI) tract and skin. They have been known for their antimicrobial activities against a variety of microbes. Recently it was discovered that they have other significant biological functions and produce appealing pharmacological actions against inflammation and cancer in the GI tract through defined mechanisms. Experimental evidence shows that these actions could be tissue and disease specific and concentration dependent. This article reviews some of the physiological functions of cathelicidins and also their therapeutic potential in the treatment of inflammation and cancer and also the delivery system for this peptide as targeted therapy for various disorders in the GI tract both in animals and humans. 展开更多
关键词 CATHELICIDIN GASTROINTESTINAL TRACT CANCER Inflammation ULCER repair
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