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Design,synthesis and biological evaluation of novel glucokinase activators 被引量:1
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作者 Yong qiang Li Yu Liang Zhang +6 位作者 Sheng Quan Hu Yu Ling Wang Hong Rui Song zhi qiang feng Lei Lei Quan Liu Zhu Fang Shen 《Chinese Chemical Letters》 SCIE CAS CSCD 2011年第1期73-76,共4页
glucokinase 使活跃之物(GKA ) 被设计并且综合的 benzamide 衍生物的一个新系列,和他们为 glucokinase 的激活被初步的 glucokinase 活动试金评估。structureactivity 关系(SAR ) 被讨论。加重 12d 和 12h 的结果表演有有势力活动参考... glucokinase 使活跃之物(GKA ) 被设计并且综合的 benzamide 衍生物的一个新系列,和他们为 glucokinase 的激活被初步的 glucokinase 活动试金评估。structureactivity 关系(SAR ) 被讨论。加重 12d 和 12h 的结果表演有有势力活动参考药 RO-28-1675。 展开更多
关键词 葡萄糖激酶 激活剂 生物评价 设计 合成 酰胺衍生物 酶活性测定 构效关系
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Applying the fractional derivative Zener model to fitting the time-dependent material viscoelasticity tested by nanoindentation 被引量:1
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作者 Long Fei Wei Wei Li +1 位作者 zhi qiang feng Jian Tao Liu 《Biosurface and Biotribology》 EI 2018年第2期58-67,共10页
Material viscoelasticity is of particular importance for polymers,biotissues and many others,due to the significant influence not only on the elastic response of structures,but also on their failure mechanism in actua... Material viscoelasticity is of particular importance for polymers,biotissues and many others,due to the significant influence not only on the elastic response of structures,but also on their failure mechanism in actual applications.In this study,the experimental tests by nanoindentations are cate gorized according to the objective parameter combined with the indenter sha pe into four distinct cases,and the Fractional Derivative Zener model(FDZM)is employed to characterize this time-dependent property.The explicit data-fitting formulas are derived to determine the relaxation modulus and creep compliance te sted with the conical and spherical inde nters.Besides,a fitting scheme is provided to facilitate the identification of these viscoelastic parameters.In comparison with the general methods adopting the Prony series or empirical models,two silent merits present:(1)fewer model coefficients necessitate being determined based on the experimental data;(2)the relaxation modulus G(t)and the creep compliance J(t)can be obtained through one indentation test,and their exact interconversion is guaranteed as well.Several sets of experimental data are applied to examine the validity of the developed approach,and three more examples are adopted to demonstrate the exact interconversion between G(t)and J(t).A few concluding remarks are drawn eventually. 展开更多
关键词 MODULUS relaxation exact
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