A thioester-functionalized triphenylamine hole-transporting molecule(TPD-SAc) was synthesized and self-assembled to form a monolayer on an ultra-thin Au film supported on indium-tin oxide glass. The modified surface w...A thioester-functionalized triphenylamine hole-transporting molecule(TPD-SAc) was synthesized and self-assembled to form a monolayer on an ultra-thin Au film supported on indium-tin oxide glass. The modified surface was characterized by aqueous contact angle, ellipsometer, atomic force microscopy, X-ray photoelectron spectroscopy, and ultraviolet photoelectron spectrometer to substantiate the formation of compact and pinhole-free monolayers. The modified organic light emitting diode device [indium-tin oxide/Au(5 nm)/self-assembled monolayers(SAM)/TPD(50 nm)/Alq_3(40 nm)/TPBI(15 nm)/LiF(1 nm)/Al(100 nm)] showed a luminance of 7303.90 cd/m^2 and a current efficiency of 8.49 cd/A with 1.78 and 2.29-fold increase, respectively, compared to the control device without SAM. The improvements were attributed to the enhanced compatibility of the organic–inorganic interface, matched energy level by introduction of an energy mediating step and superior hole-injection property of SAM molecules.展开更多
Immunoglobulin light chain amyloidosis(AL)is one of the most frequent causes of cardiac amyloidosis(CA),[1]with an estimated prevalence of 8 to 12 per million.[2−4]Multiple myeloma(MM)is hematological neoplasia origin...Immunoglobulin light chain amyloidosis(AL)is one of the most frequent causes of cardiac amyloidosis(CA),[1]with an estimated prevalence of 8 to 12 per million.[2−4]Multiple myeloma(MM)is hematological neoplasia originating from plasma cells,which is the most common disease that can lead to CA.The median age of patients with MM at diagnosis is about 65 years old.In this age group,cardiovascular diseases often co-exist,increasing the risk of adverse events related to MM treatment.By convention,the prognosis of AL-CA with MM is extremely poor,with a median survival time of five months.[5]The degree of cardiac involvement has a decisive impact on the prognosis of AL-CA pati-ents.展开更多
OBJECTIVES To analyze the differential expression of lipid spectrum between ST-segment elevated myocardial infarction(STEMI)and patients with emergency chest pain and excluded coronary artery disease(CAD),and establis...OBJECTIVES To analyze the differential expression of lipid spectrum between ST-segment elevated myocardial infarction(STEMI)and patients with emergency chest pain and excluded coronary artery disease(CAD),and establish the predictive model which could predict STEMI in the early stage.METHODS We conducted a single-center,nested case-control study using the emergency chest pain cohort of Peking Univer-sity Third Hospital.Untargeted lipidomics were conducted while LASSO regression as well as XGBoost combined with greedy algorithm were used to select lipid molecules.RESULTS Fifty-two STEMI patients along with 52 controls were enrolled.A total of 1925 lipid molecules were detected.There were 93 lipid molecules in the positive ion mode which were differentially expressed between the STEMI and the control group,while in the negative ion mode,there were 73 differentially expressed lipid molecules.In the positive ion mode,the differentially expressed lipid subclasses were mainly diacylglycerol(DG),lysophophatidylcholine(LPC),acylcarnitine(CAR),lysophospha-tidyl ethanolamine(LPE),and phosphatidylcholine(PC),while in the negative ion mode,significantly expressed lipid subclasses were mainly free fatty acid(FA),LPE,PC,phosphatidylethanolamine(PE),and phosphatidylinositol(PI).LASSO regression se-lected 22 lipids while XGBoost combined with greedy algorithm selected 10 lipids.PC(15:0/18:2),PI(19:4),and LPI(20:3)were the overlapping lipid molecules selected by the two feature screening methods.Logistic model established using the three lipids had excellent performance in discrimination and calibration both in the derivation set(AUC:0.972)and an internal validation set(AUC:0.967).In 19 STEMI patients with normal cardiac troponin,18 patients were correctly diagnosed using lipid model.CONCLUSIONS The differentially expressed lipids were mainly DG,CAR,LPC,LPE,PC,PI,PE,and FA.Using lipid molecules selected by XGBoost combined with greedy algorithm and LASSO regression to establish model could accurately predict STEMI even in the more earlier stage.展开更多
An open source Direct Simulation Monte Carlo (DSMC) code, called as dsmcFoam in OpenFOAM, is used to study a blunt body with the shape of a space crew capsule return vehicle. The rarefied gas has the Knudsen number wi...An open source Direct Simulation Monte Carlo (DSMC) code, called as dsmcFoam in OpenFOAM, is used to study a blunt body with the shape of a space crew capsule return vehicle. The rarefied gas has the Knudsen number with 0.03. The flow with a Mach number 4.35 over the capsule was simulated by DSMC. The distributions of velocity field and temperature around the capsule were calculated. This study may provide some useful information for the reentry of the return vehicle.展开更多
Polystyrene(PS) fibers with core-shell structures were fabricated by coaxial electrostatic spinning,[10_TD$IF]in which there are liquid epoxy or curing agent as the core and PS as the shell. Scanning electron microsco...Polystyrene(PS) fibers with core-shell structures were fabricated by coaxial electrostatic spinning,[10_TD$IF]in which there are liquid epoxy or curing agent as the core and PS as the shell. Scanning electron microscopy(SEM), Fourier transform infrared(FTIR) spectra and optical microscope were utilized for charactering the morphology and composition of the fibers. Composite coatings embedded with the healant-loaded coreshell fibers have been prepared and the self-healing of the scratch on the coatings has been revealed.展开更多
Usually simulations on environment flood issues will face the scalability problem of large scale parallel computing.The plain parallel technique based on pure MPI is difficult to have a good scalability due to the lar...Usually simulations on environment flood issues will face the scalability problem of large scale parallel computing.The plain parallel technique based on pure MPI is difficult to have a good scalability due to the large number of domain partitioning.Therefore,the hybrid programming using MPI and OpenMP is introduced to deal with the issue of scalability.This kind of parallel technique can give a full play to the strengths of MPI and OpenMP.During the parallel computing,OpenMP is employed by its efficient fine grain parallel computing and MPI is used to perform the coarse grain parallel domain partitioning for data communications.Through the tests,the hybrid MPI/OpenMP parallel programming was used to renovate the finite element solvers in the BIEF library of Telemac.It was found that the hybrid programming is able to provide helps for Telemac to deal with the scalability issue.展开更多
Lattice Boltzmann method(LBM)is a new attractive computational approach for simulating isothermal multi-phase flows in computational fluid dynamics(CFD).It is based on the kinetic theory and easy to be parallelized.Th...Lattice Boltzmann method(LBM)is a new attractive computational approach for simulating isothermal multi-phase flows in computational fluid dynamics(CFD).It is based on the kinetic theory and easy to be parallelized.This study aims to analyze the performance of parallel LBM programming for the incompressible two-phase flows at high density and viscosity ratio.For this purpose,a liquid drop impact on a wetted wall with a pre-existing thin film of the same liquid is simulated by using the parallel LBM code.During the simulations,the domain decomposition,data communication and parallelization of the LBM code using the message passing interface(MPI)library have been investigated.The computational results show that the parallel LBM code exhibits a good high performance computing(HPC)on the parallel speed-up.展开更多
基金supported by the National Natural Science Foundation of China(Nos.21506151,21576195 and 21776207)
文摘A thioester-functionalized triphenylamine hole-transporting molecule(TPD-SAc) was synthesized and self-assembled to form a monolayer on an ultra-thin Au film supported on indium-tin oxide glass. The modified surface was characterized by aqueous contact angle, ellipsometer, atomic force microscopy, X-ray photoelectron spectroscopy, and ultraviolet photoelectron spectrometer to substantiate the formation of compact and pinhole-free monolayers. The modified organic light emitting diode device [indium-tin oxide/Au(5 nm)/self-assembled monolayers(SAM)/TPD(50 nm)/Alq_3(40 nm)/TPBI(15 nm)/LiF(1 nm)/Al(100 nm)] showed a luminance of 7303.90 cd/m^2 and a current efficiency of 8.49 cd/A with 1.78 and 2.29-fold increase, respectively, compared to the control device without SAM. The improvements were attributed to the enhanced compatibility of the organic–inorganic interface, matched energy level by introduction of an energy mediating step and superior hole-injection property of SAM molecules.
基金This work was supported by grants from the National Natural Science Foundation of China(grant No.81972149,81871850)Beijing Natural Science Foundation(grant No.7212125).
文摘Immunoglobulin light chain amyloidosis(AL)is one of the most frequent causes of cardiac amyloidosis(CA),[1]with an estimated prevalence of 8 to 12 per million.[2−4]Multiple myeloma(MM)is hematological neoplasia originating from plasma cells,which is the most common disease that can lead to CA.The median age of patients with MM at diagnosis is about 65 years old.In this age group,cardiovascular diseases often co-exist,increasing the risk of adverse events related to MM treatment.By convention,the prognosis of AL-CA with MM is extremely poor,with a median survival time of five months.[5]The degree of cardiac involvement has a decisive impact on the prognosis of AL-CA pati-ents.
基金This work was supported by the National Key Research and Development Program of China(2017 YFC0908701)National Natural Science Foundation of China(81972149,81871850)Beijing Natural Science Foundation(grant No.7212125).
文摘OBJECTIVES To analyze the differential expression of lipid spectrum between ST-segment elevated myocardial infarction(STEMI)and patients with emergency chest pain and excluded coronary artery disease(CAD),and establish the predictive model which could predict STEMI in the early stage.METHODS We conducted a single-center,nested case-control study using the emergency chest pain cohort of Peking Univer-sity Third Hospital.Untargeted lipidomics were conducted while LASSO regression as well as XGBoost combined with greedy algorithm were used to select lipid molecules.RESULTS Fifty-two STEMI patients along with 52 controls were enrolled.A total of 1925 lipid molecules were detected.There were 93 lipid molecules in the positive ion mode which were differentially expressed between the STEMI and the control group,while in the negative ion mode,there were 73 differentially expressed lipid molecules.In the positive ion mode,the differentially expressed lipid subclasses were mainly diacylglycerol(DG),lysophophatidylcholine(LPC),acylcarnitine(CAR),lysophospha-tidyl ethanolamine(LPE),and phosphatidylcholine(PC),while in the negative ion mode,significantly expressed lipid subclasses were mainly free fatty acid(FA),LPE,PC,phosphatidylethanolamine(PE),and phosphatidylinositol(PI).LASSO regression se-lected 22 lipids while XGBoost combined with greedy algorithm selected 10 lipids.PC(15:0/18:2),PI(19:4),and LPI(20:3)were the overlapping lipid molecules selected by the two feature screening methods.Logistic model established using the three lipids had excellent performance in discrimination and calibration both in the derivation set(AUC:0.972)and an internal validation set(AUC:0.967).In 19 STEMI patients with normal cardiac troponin,18 patients were correctly diagnosed using lipid model.CONCLUSIONS The differentially expressed lipids were mainly DG,CAR,LPC,LPE,PC,PI,PE,and FA.Using lipid molecules selected by XGBoost combined with greedy algorithm and LASSO regression to establish model could accurately predict STEMI even in the more earlier stage.
文摘An open source Direct Simulation Monte Carlo (DSMC) code, called as dsmcFoam in OpenFOAM, is used to study a blunt body with the shape of a space crew capsule return vehicle. The rarefied gas has the Knudsen number with 0.03. The flow with a Mach number 4.35 over the capsule was simulated by DSMC. The distributions of velocity field and temperature around the capsule were calculated. This study may provide some useful information for the reentry of the return vehicle.
基金financially supported by the MOS of China (No. 2017YFB0703300)the National Natural Science Foundation ofChina (No. 51673117)the Science and Technology Innovation Commission of Shenzhen (Nos. JSGG20160226201833790, JCYJ20150625102750478)
文摘Polystyrene(PS) fibers with core-shell structures were fabricated by coaxial electrostatic spinning,[10_TD$IF]in which there are liquid epoxy or curing agent as the core and PS as the shell. Scanning electron microscopy(SEM), Fourier transform infrared(FTIR) spectra and optical microscope were utilized for charactering the morphology and composition of the fibers. Composite coatings embedded with the healant-loaded coreshell fibers have been prepared and the self-healing of the scratch on the coatings has been revealed.
文摘Usually simulations on environment flood issues will face the scalability problem of large scale parallel computing.The plain parallel technique based on pure MPI is difficult to have a good scalability due to the large number of domain partitioning.Therefore,the hybrid programming using MPI and OpenMP is introduced to deal with the issue of scalability.This kind of parallel technique can give a full play to the strengths of MPI and OpenMP.During the parallel computing,OpenMP is employed by its efficient fine grain parallel computing and MPI is used to perform the coarse grain parallel domain partitioning for data communications.Through the tests,the hybrid MPI/OpenMP parallel programming was used to renovate the finite element solvers in the BIEF library of Telemac.It was found that the hybrid programming is able to provide helps for Telemac to deal with the scalability issue.
基金support by Multiphase Flow for Deep-Sea Oil&Gas Down-hole Applications-SERC TSRP Programme of Agency for Science,Technology and Research(A-STAR)in Singapore(Ref#:1021640075)This work was supported from A"STAR computational resource centre(A'CRC)in Singapore for providing the high performance computing facilities.
文摘Lattice Boltzmann method(LBM)is a new attractive computational approach for simulating isothermal multi-phase flows in computational fluid dynamics(CFD).It is based on the kinetic theory and easy to be parallelized.This study aims to analyze the performance of parallel LBM programming for the incompressible two-phase flows at high density and viscosity ratio.For this purpose,a liquid drop impact on a wetted wall with a pre-existing thin film of the same liquid is simulated by using the parallel LBM code.During the simulations,the domain decomposition,data communication and parallelization of the LBM code using the message passing interface(MPI)library have been investigated.The computational results show that the parallel LBM code exhibits a good high performance computing(HPC)on the parallel speed-up.