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经导管肝动脉化疗栓塞术联合鸦胆子油乳液静脉滴注对原发性肝癌的疗效及VEGF水平的影响 被引量:18
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作者 董智刚 马丽丽 +4 位作者 张占红 贾绍华 佟克杰 杨丽英 李亚娟 《中国现代医学杂志》 CAS 2018年第18期88-92,共5页
目的探讨经导管肝动脉化疗栓塞术(TACE)联合鸦胆子油乳液静脉滴注对原发性肝癌患者的临床疗效及对血管内皮生长因子(VEGF)表达水平的影响。方法选取2012年3月-2013年3月该院收治的肝癌患者88例,使用随机数字表法分为研究组及对照组,每组... 目的探讨经导管肝动脉化疗栓塞术(TACE)联合鸦胆子油乳液静脉滴注对原发性肝癌患者的临床疗效及对血管内皮生长因子(VEGF)表达水平的影响。方法选取2012年3月-2013年3月该院收治的肝癌患者88例,使用随机数字表法分为研究组及对照组,每组各44例,对照组患者单用TACE治疗,研究组采用TACE加鸦胆子油乳液静脉滴注。所有患者治疗至少3个疗程并随访6~37个月。比较两组患者治疗后的临床疗效、不良反应发生率、中位疾病进展时间(TTP)及总生存率,同时比较治疗前后肝功能、血浆内毒素及VEGF的水平。结果观察组的治疗总有效率及中位TTP高于对照组(P<0.01);治疗后,观察组的不良反应发生率低于对照组(P<0.01);两组肝功能指标、血浆内毒素及VEGF的水平均升高,但观察组低于对照组(P<0.01);两组1~3年的总生存率相比差异无统计学意义(P>0.05)。结论鸦胆子油乳液辅助TACE治疗原发性肝癌可改善患者的近期疗效和肝功能,延长TPP时间,降低血浆内毒素、VEGF的水平,是一种安全有效的方法。 展开更多
关键词 鸦胆子油乳液 经导管肝动脉化疗栓塞术 肝癌 血管内皮生长因子 内毒素
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Smooth particle hydrodynamics modeling of cutting force in milling process of TC4 被引量:5
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作者 Xiao-Guang Guo Ming Li +3 位作者 zhi-gang dong Rui-Feng Zhai Zhu-Ji Jin Ren-Ke Kang 《Advances in Manufacturing》 SCIE CAS CSCD 2019年第4期364-373,共10页
Milling is one of the main methods for processing titanium alloy.At present,the complex process of milling is usually simulated by finite element method,which often has problems in mesh distortion and mesh reconstruct... Milling is one of the main methods for processing titanium alloy.At present,the complex process of milling is usually simulated by finite element method,which often has problems in mesh distortion and mesh reconstruction.Therefore,a meshless three-dimensional milling simulation model was established for TC4 titanium alloy using the smooth particle hydrodynamics(SPH)method.Firstly,the established SPH model was analyzed by the LS-DYNA software,and the stress distribution,temperature field,and cutting force during milling were studied under specific conditions.Subsequently,the cutting force was simulated under different cutting parameters and the effects of these parameters on the cutting force were determined.Finally,based on a series of cutting force experiments,the accuracy of the simulation model was verified.This study proves the feasibility of SPH method in the simulation of titanium alloy milling process and provides novel methods for investigating the processing mechanism and optimizing the processing technology of titanium alloys. 展开更多
关键词 TC4 titanium Smooth particle hydrodynamics(SPH)-Milling Cutting temperature Cutting force
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Study into grinding force in back grinding of wafer with outer rim
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作者 Xiang-Long Zhu Yu Li +2 位作者 zhi-gang dong Ren-Ke Kang Shang Gao 《Advances in Manufacturing》 SCIE CAS CSCD 2020年第3期361-368,共8页
Back grinding of wafer with outer rim(BGWOR)is a new method for carrier-less thinning of silicon wafers.At present,the effects of process parameters on the grinding force remain debatable.Therefore,a BGWOR normal grin... Back grinding of wafer with outer rim(BGWOR)is a new method for carrier-less thinning of silicon wafers.At present,the effects of process parameters on the grinding force remain debatable.Therefore,a BGWOR normal grinding force model based on grain depth-of-cut was established,and the relationship between grinding parameters(wheel infeed rate,wheel rotational speed,and chuck rotational speed)and normal grinding force was discussed.Further,a series of experiments were performed to verify the BGWOR normal grinding force model.This study proves that the BGWOR normal grinding force is related to the rotational direction of the wheel and chuck,and the effect of grinding mark density on the BGWOR normal grinding force cannot be ignored.Moreover,this study provides methods for reducing the grinding force and optimizing the back thinning process of the silicon wafer. 展开更多
关键词 Silicon wafer Back grinding of wafer with outer rim(BGWOR) Grinding force Grinding mark density
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