AIM:To evaluate potential risk factors in the development of ulcerative colitis(UC) in China.METHODS:A total of 1308 patients with UC and 1308 age-matched and sex-matched controls were prospectively studied in China.T...AIM:To evaluate potential risk factors in the development of ulcerative colitis(UC) in China.METHODS:A total of 1308 patients with UC and 1308 age-matched and sex-matched controls were prospectively studied in China.The UC cases were collected from 17 hospitals in China from April 2007 to April 2010.Uniform questionnaires were designed to investigate risk factors including smoking,appendectomy,stress,socio-economic conditions,nonsteroidal antiinflammatory drugs(NSAIDs),oral contraceptives,diet,breastfeeding,infections and family sanitary conditions.Group comparisons by each factor were done using simple logistic regression analysis.Conditional logistic regression was used for multivariate analysis.RESULTS:By univariate analysis,the variables predictive of UC included feeling stress,light and heavy alcoholic drinking,spicy food,sugar consumption and infectious diarrhea,while heavy tea intake and tap water consumption were protective against UC.On multivariate analysis,the protective factor for UC was tap water consumption [odds ratios(OR) = 0.424,95%CI:0.302-0.594,P < 0.001];while the potential risk factors for UC were heavy sugar consumption(OR = 1.632,95%CI:1.156-2.305,P < 0.001),spicy food(light intake:OR = 3.329,95%CI:2.282-4.857,P < 0.001;heavy intake:OR = 3.979,95%CI:2.700-5.863,P < 0.001),and often feeling stress(OR = 1.981,95%CI:1.447-2.711,P < 0.001).Other factors,such as smoking habit,appendectomy,breastfeeding,a history of measles,rural or urban residence,education,oral contraceptives,and NSAID use have not been found to have a significant association with the development of UC in the present study.CONCLUSION:Our study showed tap water consumption was a protective factor for UC,while spicy food,heavy sugar consumption and often feeling stress were risk factors for UC in this Chinese population.展开更多
基金Supported by A Grant from Chinese Medical Association Re-search Special Funds,No. 07040490057 (to Professor Ou-yang Q)
文摘AIM:To evaluate potential risk factors in the development of ulcerative colitis(UC) in China.METHODS:A total of 1308 patients with UC and 1308 age-matched and sex-matched controls were prospectively studied in China.The UC cases were collected from 17 hospitals in China from April 2007 to April 2010.Uniform questionnaires were designed to investigate risk factors including smoking,appendectomy,stress,socio-economic conditions,nonsteroidal antiinflammatory drugs(NSAIDs),oral contraceptives,diet,breastfeeding,infections and family sanitary conditions.Group comparisons by each factor were done using simple logistic regression analysis.Conditional logistic regression was used for multivariate analysis.RESULTS:By univariate analysis,the variables predictive of UC included feeling stress,light and heavy alcoholic drinking,spicy food,sugar consumption and infectious diarrhea,while heavy tea intake and tap water consumption were protective against UC.On multivariate analysis,the protective factor for UC was tap water consumption [odds ratios(OR) = 0.424,95%CI:0.302-0.594,P < 0.001];while the potential risk factors for UC were heavy sugar consumption(OR = 1.632,95%CI:1.156-2.305,P < 0.001),spicy food(light intake:OR = 3.329,95%CI:2.282-4.857,P < 0.001;heavy intake:OR = 3.979,95%CI:2.700-5.863,P < 0.001),and often feeling stress(OR = 1.981,95%CI:1.447-2.711,P < 0.001).Other factors,such as smoking habit,appendectomy,breastfeeding,a history of measles,rural or urban residence,education,oral contraceptives,and NSAID use have not been found to have a significant association with the development of UC in the present study.CONCLUSION:Our study showed tap water consumption was a protective factor for UC,while spicy food,heavy sugar consumption and often feeling stress were risk factors for UC in this Chinese population.
基金supported by the Chinese National Scientific Research Special-Purpose Project in Public Health Profession Funds[No.201002020]National Natural Science Foundation of China[81421003 and 81627807]+1 种基金National Key Research and Development Plan[2017YFC0908300]Independent Funds of the Key Laboratory[CBSKL2015Z01].
文摘背景:单中心或小样本研究数据显示,染色内镜用于溃疡性结肠炎(UC)患者的瘤变监测可能优于白光内镜。我们进行了一项前瞻性随机试验,通过对UC患者的长期随访,比较白光内镜加靶向活检(WLT)、白光内镜加随机活检(WLR)与染色内镜加靶向活检(CET)的肿瘤检出率。方法:前瞻性纳入2012年3月至2013年12月间11个医学中心收治的UC患者,随机分为WLT、WLR、CET三组。三组患者均仅行高清内镜检查,每年内镜随访一次,直至2017年12月。结果:中位随访55个月,122例入组患者完成了447次内镜检查,纳入最终的完成方案分析,其中WLT组43例,WLR组40例,CET组39例。在21例患者的29次肠镜检查中,共发现34个瘤变。WLR组和CET组诊断瘤变的肠镜检查比例高于WLT组(8.1%和9.7%vs 1.9%;P=0.014,P=0.004)。WLR组活检样本数量显著多于WLT组和CET组(16.4±5.1 vs 4.4±1.4和4.3±3.5;均P<0.001)。在后半程随访中(37-69个月),CET组诊断瘤变的肠镜比例显著高于WLT组(13.3%vs 1.6%,P=0.015),较WLR组则显示出了增高的趋势(13.3%vs 4.9%,P=0.107)。结论:对于UC患者的癌变/瘤变长期监测,CET比WLT更加高效,比WLR更加简单,尤其适用于3年以上的长期随访。本研究于www.chictr.org.cn进行注册(ChiCTR1900023689)。
