Study on influencing factors of beta cell early stage dysfunction in pre-diabetes

Objective:To study the effects of obesity,blood lipids,age and other factors on early functional defects ofβcells in pre-diabetes.Methods:Thirty-seven IGR subjects who met the study conditions were randomly selected,and 42 T2DM subjects were used as the control group.General items such as BMI and TG were evaluated.Standard steamed bread test was used to evaluate the subjects'fasting,30 minutes,60 minutes,120 minutes,180 minutes of insulin,C-peptide secretion and peak time.HOMA-IR index and Matsuda index were used to evaluate insulin sensitivity.HOMA-βand AUCI/AUCG were used to evaluateβ-cell Function.Results:The results of BMI,TG,Matsuda index,HOMA-βand AUCI/AUCG in IGR group were higher than those in T2DM group,and HOMA-IR was lower than those in T2DM group(P<0.05).BMI and TG in IGR group were positively correlated with fasting and late phase secretion ofβcells,positively correlated with time of peak secretion ofβcells,positively correlated with HOMA-IR(P<0.05)and negatively correlated with Matsuda index(P<0.05),and age factor in IGR group was significantly correlated with HOMA-βand AUCI/AUCG.(P<0.05).After controlling for BMI and TG,age was still associated with HOMA-βand AUCI/AUCG.(P<0.05);BMI in IGR and T2DM groups were positively correlated withβ-cell HOMA-βand AUCI/AUCG functional indexes,(P<0.05);TG,late-phase insulin secretion value and peak time of insulin secretion andβ-cell secretion index AUCI/AUCG index in IGR obese group were higher than those in non-obese group(P<0.05),and insulin resistance index Matsuda was lower than those in the non-obese group.(P<0.05).Conclusion:The increase of BMI,TG and age are the important factors that affect the early function defect ofβcell in the stage of IGR,especially the correlation between BMI,TG and IGR is greater than that of T2DM,which should be the target of intervention,control and treatment in the early stage of diabetes.