Objective:To explore the relationship among plasma 3-deoxyglucuronide (3-DG) level, severity of sepsis and clinical prognosis, and to provide references for the assessment of sepsis patients' condition and prognos...Objective:To explore the relationship among plasma 3-deoxyglucuronide (3-DG) level, severity of sepsis and clinical prognosis, and to provide references for the assessment of sepsis patients' condition and prognosis.Methods:120 sepsis patients and 50 health particapants in our hospital from January 2018 to December 2018 were enrolled in the observation group and the control group respectively. The plasma levels of 3-DG were measured and compared between the two groups at the time of admission. According to the 28-day prognosis of the patients in the observation group, they were divided into the survival group and the death group. The plasma 3-DG changes and acute physiology and chronic health scoring system II (APACHE II) and Glasgow coma score (GCS) were compared between the two groups at the time of enrollment, on the third day of admission, on the 7th day of admission, on the 14th day after admission. The correlation between plasma 3-DG and the severity score of sepsis patients was analyzed, and the value of plasma 3-DG in predicting the mortality of sepsis patients was analyzed by ROC.Results:The plasma concentration of 3-DG in the observation groupwas (296.38±52.97)μg/L, which was higher than that in the control group (91.06±22.38)μg/L, and the difference was statistically significant. After 28 d of hospitalization, 81 patients survived and 39 died in the observation group, with a fatality rate of 32.50%. The plasma levels of 3-DG in the survival group and the death group decreased continuously at the time of admission, the 3rd day of admission, the 7th day of admission and the 14th day of admission. The plasma 3-DG levels of survival group and fatality group decreased continuously at admission, 3rd day, 7th day and 14th day. The plasma 3-DG levels of the survival group were lower than those of the fatality group at admission, 3rd day, 7th day and 14th day. The scores of APACHE II, SOFA and MODS of the survival group and the fatality group decreased continuously at admission, 3rd day, 7th day, 14th day, and increased continuously. The scores of APACHE II, SOFA and MODS of the survival group and the fatality group were lower than those of the fatality group at admission, 3rd day, 7th day, 14th day, and their GCS scores were higher than those of the fatality group, with significant difference. Pearson correlation analysis showed that plasma 3-DG level was positively correlated with APACHE II, SOFA, MODS scores in sepsis patients, and negatively correlated with GCS scores. ROC curve showed that plasma 3-DG levels at admission, 3rd day of admission, 7th day of admission and 14th day of admission could effectively predict the mortality risk of sepsis patients ion were 82.22%, 80.35% and AUC was 0.871, respectively.Conclusion:The increase of plasma 3-DG level is accompanied by the aggravation of the severity of sepsis and the increase of the risk of fatality. Early detection of plasma 3-DG level is expected to guide the assessment of the condition and prognosis of sepsis patients.展开更多
文摘Objective:To explore the relationship among plasma 3-deoxyglucuronide (3-DG) level, severity of sepsis and clinical prognosis, and to provide references for the assessment of sepsis patients' condition and prognosis.Methods:120 sepsis patients and 50 health particapants in our hospital from January 2018 to December 2018 were enrolled in the observation group and the control group respectively. The plasma levels of 3-DG were measured and compared between the two groups at the time of admission. According to the 28-day prognosis of the patients in the observation group, they were divided into the survival group and the death group. The plasma 3-DG changes and acute physiology and chronic health scoring system II (APACHE II) and Glasgow coma score (GCS) were compared between the two groups at the time of enrollment, on the third day of admission, on the 7th day of admission, on the 14th day after admission. The correlation between plasma 3-DG and the severity score of sepsis patients was analyzed, and the value of plasma 3-DG in predicting the mortality of sepsis patients was analyzed by ROC.Results:The plasma concentration of 3-DG in the observation groupwas (296.38±52.97)μg/L, which was higher than that in the control group (91.06±22.38)μg/L, and the difference was statistically significant. After 28 d of hospitalization, 81 patients survived and 39 died in the observation group, with a fatality rate of 32.50%. The plasma levels of 3-DG in the survival group and the death group decreased continuously at the time of admission, the 3rd day of admission, the 7th day of admission and the 14th day of admission. The plasma 3-DG levels of survival group and fatality group decreased continuously at admission, 3rd day, 7th day and 14th day. The plasma 3-DG levels of the survival group were lower than those of the fatality group at admission, 3rd day, 7th day and 14th day. The scores of APACHE II, SOFA and MODS of the survival group and the fatality group decreased continuously at admission, 3rd day, 7th day, 14th day, and increased continuously. The scores of APACHE II, SOFA and MODS of the survival group and the fatality group were lower than those of the fatality group at admission, 3rd day, 7th day, 14th day, and their GCS scores were higher than those of the fatality group, with significant difference. Pearson correlation analysis showed that plasma 3-DG level was positively correlated with APACHE II, SOFA, MODS scores in sepsis patients, and negatively correlated with GCS scores. ROC curve showed that plasma 3-DG levels at admission, 3rd day of admission, 7th day of admission and 14th day of admission could effectively predict the mortality risk of sepsis patients ion were 82.22%, 80.35% and AUC was 0.871, respectively.Conclusion:The increase of plasma 3-DG level is accompanied by the aggravation of the severity of sepsis and the increase of the risk of fatality. Early detection of plasma 3-DG level is expected to guide the assessment of the condition and prognosis of sepsis patients.
