Photocurrent-voltage characterization is a crucial method for assessing key parameters in x-ray or y-ray semiconductor detectors,especially the carrier mobility lifetime product.However,the high biases during photocur...Photocurrent-voltage characterization is a crucial method for assessing key parameters in x-ray or y-ray semiconductor detectors,especially the carrier mobility lifetime product.However,the high biases during photocurrent measurements tend to cause severe ion migration,which can lead to the instability and inaccuracy of the test results.Given the mixed electronic-ionic charac teristics,it is imperative to devise novel methods capable of precisely measuring photocurrentvoltage characteristics under high bias conditions,free from interference caused by ion migration.In this paper,pulsed bias is employed to explore the photocurrent-voltage characteristics of MAPbBr_(3) single crystals.The method yields stable photocurrent-voltage characteristics at a pulsed bias of up to 30 V,proving to be effective in mitigating ion migration.Through fitting the modified Hecht equation,we determined the mobility lifetime products of 1.0×10^(2) cm^(2)·V^(-1)for hole and 2.78×10~(-3)cm^(2)·V^(-1)for electron.This approach offers a promising solution for accurately measuring the transport properties of carriers in perovskite.展开更多
目的探讨动态增强磁共振成像(dynamic contrast-enhanced magnetic resonance imaging,DCE-MRI)技术在子宫颈癌临床分期中的应用价值。方法对2019年1月至2021年12月在郑州大学第二附属医院行手术治疗的186例子宫颈癌患者进行回顾性分析...目的探讨动态增强磁共振成像(dynamic contrast-enhanced magnetic resonance imaging,DCE-MRI)技术在子宫颈癌临床分期中的应用价值。方法对2019年1月至2021年12月在郑州大学第二附属医院行手术治疗的186例子宫颈癌患者进行回顾性分析。所有患者术前均行DCE-MRI技术以协助评估临床分期、宫颈肌层浸润、子宫体浸润、阴道累及、宫旁转移、淋巴结转移等相关参数,以术后病理为金标准进行验证,分析DCE-MRI技术术前评估子宫颈癌分期的准确度、灵敏度及特异度。结果186例子宫颈癌患者临床分期与手术病理分期一致性较好(Kappa=0.862,P<0.001),165例(88.71%)临床分期与手术病理分期一致。DCE-MRI诊断阴道累及的准确度为96.24%、灵敏度为86.96%、特异度为97.55%;诊断淋巴结转移的准确度为97.31%、灵敏度为82.35%、特异度为98.82%;诊断深肌层浸润的准确度为86.56%、灵敏度为90.79%、特异度为83.63%。结论DCE-MRI技术在诊断阴道累及、淋巴结转移、深肌层浸润等方面具有较高的灵敏度与特异度,可为子宫颈癌术前临床分期评估提供参考。展开更多
In this study,a novel photosensitizer mesc-tetra(3-prrolidinomethyl-4-methoxyphenyl)chlorin(TPMC)was reported.It displays a characteristic long wavelength absorption peak at 656 nm and it shows a singlet oxygen quantu...In this study,a novel photosensitizer mesc-tetra(3-prrolidinomethyl-4-methoxyphenyl)chlorin(TPMC)was reported.It displays a characteristic long wavelength absorption peak at 656 nm and it shows a singlet oxygen quantum yield of 0.48.After light iradiation with 650 nm laser,it can kill Eca-109 and SMMC-7721 cells in vitro(25 mW/cm^(2),1.2 to 3.6J/cm^(2))and destroy Eca-109 tumor in nude mice(50 mW/cm^(2),90J/cm^(2)).It has the perspective to be developed as a new anti-tumor drug in photodynamic therapy(PDT)photodiagnosis,and deserves further investigation.展开更多
Photodynamic therapy(PDT)represents a promising method for treatment of cancerous tumors.The chemical and physical properties of used photosensitizer(PS)play key roles in the treat ment efficacy.In this study,a novel ...Photodynamic therapy(PDT)represents a promising method for treatment of cancerous tumors.The chemical and physical properties of used photosensitizer(PS)play key roles in the treat ment efficacy.In this study,a novel PS,5,10,15,20-tetrais((5-dipropylamino)pentyl)-chlorin(TDPC)which displayed a characteristic long wavelength absorption peak at 650 nm were synthesized.It also shows a singlet oxygen generation rate of 4.257 min^(-1).Generally,TDPC is localized in mitochondria and nucleus of cell.After light irradiation with 650 nm laser,it can kill many types of cell,in addition,TDPC-PDT can destroy ECA-109 tunor in nude mice and a necrotic scab was formed eventually.The expression levels of many genes which regulated cell growth and apoptosis were determined by RT-PCR following TDPC-PDT.The results showed that it either increased or decreased,among which,the expression level of TNFSF13,a member of tumor necrosis factor superfamily,increased signifcantly.In general,TDPC is an elective antitumor PS in vitro and in vito and is worthy of further study as a new drug candidate.TNFSF13 will be an important molecular target for the discovery of new PSs.展开更多
基金Project supported by the National Natural Science Foundation of China (Grant No.62104234)Shanghai Explorer Program (Grant No.22TS1400100)。
文摘Photocurrent-voltage characterization is a crucial method for assessing key parameters in x-ray or y-ray semiconductor detectors,especially the carrier mobility lifetime product.However,the high biases during photocurrent measurements tend to cause severe ion migration,which can lead to the instability and inaccuracy of the test results.Given the mixed electronic-ionic charac teristics,it is imperative to devise novel methods capable of precisely measuring photocurrentvoltage characteristics under high bias conditions,free from interference caused by ion migration.In this paper,pulsed bias is employed to explore the photocurrent-voltage characteristics of MAPbBr_(3) single crystals.The method yields stable photocurrent-voltage characteristics at a pulsed bias of up to 30 V,proving to be effective in mitigating ion migration.Through fitting the modified Hecht equation,we determined the mobility lifetime products of 1.0×10^(2) cm^(2)·V^(-1)for hole and 2.78×10~(-3)cm^(2)·V^(-1)for electron.This approach offers a promising solution for accurately measuring the transport properties of carriers in perovskite.
文摘目的探讨动态增强磁共振成像(dynamic contrast-enhanced magnetic resonance imaging,DCE-MRI)技术在子宫颈癌临床分期中的应用价值。方法对2019年1月至2021年12月在郑州大学第二附属医院行手术治疗的186例子宫颈癌患者进行回顾性分析。所有患者术前均行DCE-MRI技术以协助评估临床分期、宫颈肌层浸润、子宫体浸润、阴道累及、宫旁转移、淋巴结转移等相关参数,以术后病理为金标准进行验证,分析DCE-MRI技术术前评估子宫颈癌分期的准确度、灵敏度及特异度。结果186例子宫颈癌患者临床分期与手术病理分期一致性较好(Kappa=0.862,P<0.001),165例(88.71%)临床分期与手术病理分期一致。DCE-MRI诊断阴道累及的准确度为96.24%、灵敏度为86.96%、特异度为97.55%;诊断淋巴结转移的准确度为97.31%、灵敏度为82.35%、特异度为98.82%;诊断深肌层浸润的准确度为86.56%、灵敏度为90.79%、特异度为83.63%。结论DCE-MRI技术在诊断阴道累及、淋巴结转移、深肌层浸润等方面具有较高的灵敏度与特异度,可为子宫颈癌术前临床分期评估提供参考。
基金supported by Chinese National Natural Science Foundation (21372042,81301878,81101298)Foundation of Shanghai government (13431900700,13430722300,13ZR1441000,13ZR1440900)+3 种基金Foundation of Donghua University (No.11D1050112D10515)Foundation of Yiwu Science and Technology Bureau (2011-G1-152012-G3-02).
文摘In this study,a novel photosensitizer mesc-tetra(3-prrolidinomethyl-4-methoxyphenyl)chlorin(TPMC)was reported.It displays a characteristic long wavelength absorption peak at 656 nm and it shows a singlet oxygen quantum yield of 0.48.After light iradiation with 650 nm laser,it can kill Eca-109 and SMMC-7721 cells in vitro(25 mW/cm^(2),1.2 to 3.6J/cm^(2))and destroy Eca-109 tumor in nude mice(50 mW/cm^(2),90J/cm^(2)).It has the perspective to be developed as a new anti-tumor drug in photodynamic therapy(PDT)photodiagnosis,and deserves further investigation.
基金supported by Chinese National Natural Science Foundation (21372042,81301878,81101298)Foundation of Shanghai government (13431900700,13430722300,13ZR1441000,13ZR1440900)+1 种基金Foundation of Donghua University (No.11D10501,12D10515)Foundation of Yiwu Science and Technology Bureau (2011-G1-15,2012-G3-02).
文摘Photodynamic therapy(PDT)represents a promising method for treatment of cancerous tumors.The chemical and physical properties of used photosensitizer(PS)play key roles in the treat ment efficacy.In this study,a novel PS,5,10,15,20-tetrais((5-dipropylamino)pentyl)-chlorin(TDPC)which displayed a characteristic long wavelength absorption peak at 650 nm were synthesized.It also shows a singlet oxygen generation rate of 4.257 min^(-1).Generally,TDPC is localized in mitochondria and nucleus of cell.After light irradiation with 650 nm laser,it can kill many types of cell,in addition,TDPC-PDT can destroy ECA-109 tunor in nude mice and a necrotic scab was formed eventually.The expression levels of many genes which regulated cell growth and apoptosis were determined by RT-PCR following TDPC-PDT.The results showed that it either increased or decreased,among which,the expression level of TNFSF13,a member of tumor necrosis factor superfamily,increased signifcantly.In general,TDPC is an elective antitumor PS in vitro and in vito and is worthy of further study as a new drug candidate.TNFSF13 will be an important molecular target for the discovery of new PSs.
