Changes in rheumatoid arthritis under ultrasound before and after sinomenine injection

BACKGROUND Rheumatoid arthritis(RA)is a prevalent clinical autoimmune disease that is commonly treated with diclofenac and methotrexate.In recent years,the application of traditional Chinese medicine in RA has received widespread attention;it promotes blood circulation,strengthens the immune system,and eliminates evil.The sinomenine preparation of Zhingqeng Fengtongning is studied as a possible treatment for patients with RA.AIM To explore the value of sinomenine injection into the articular cavity for the treatment of RA.METHODS A total of 94 patients with RA treated from January 2019 to January 2021 were selected and divided into the study and control groups with 47 patients each using a simple random number table method.Both groups received conventional treatment with diclofenac sodium and methotrexate tablets.The control group received diproxone and lidocaine by intra-articular administration while the study group received an intra-articular administration of the sinomenine preparation of Zhengqing Fengning and lidocaine.χ^(2) test was used to evaluate the therapeutic effect and synovial thickness,degree of pain through the visual analog scale(VAS),blood flow grade,arthroinflammatory indexes[rheumatoid factor(RF),C-reactive protein(CRP),and erythrocyte sedimentation rate(ESR)]before and after treatment in the two groups.RESULTS The total effective rate of the study group(93.62%)was higher than that of the control group(78.72%)(P<0.05).Before treatment,there were no significant differences between the two groups in terms of synovial thickness,VAS score,blood flow grading,levels of RF,and ESR(P>0.05).After treatment,the synovial thickness and VAS score were significantly lower(P<0.05)in the study group than in the control group(2.05±0.59 mm vs 2.87±0.64 mm and 2.11±0.62 vs 2.90±0.79 scores,respectively).The rate of blood flow at grade 0 in the study group(76.60%)was higher than that in the control group(57.45%),and the rate of blood flow at grade I(10.64%)was lower than that in the control group(31.91%)(P<0.05).Furthermore,the levels of RF(55.61±6.13 U/mL),CRP(11.43±3.59 mg/L),and ESR(29.60±5.56 mm/h)in the study group were lower than those in the control group(73.04±9.23 U/mL,15.07±4.06 mg/L,36.64±6.10 mm/h,respectively)(P<0.05).CONCLUSION Sinomenine administration of Zhengqing Fengtongning in the articular cavity with conventional treatment of RA can improve ultrasonographic blood flow and synovial thickness,reduce pain,regulate inflammation,and enhance therapeutic effect.

Effects of laparoscopic normal hepatectomy and partial hepatectomy on inflammatory factors, stress hormones and immune function in patients with intrahepatic cholelithiasis

Objective:To investigate the effects of laparoscopic normal hepatectomy and partial open hepatectomy on inflammatory factors, stress hormones and immune function in patients with intrahepatic cholelithiasis.Methods: A total of 90 patients with intrahepatic cholelithiasis were randomly divided into control group and the observation group. The patients in the control group were treated with partial hepatectomy. Patients in observation group were treated with laparoscopic normal hepatectomy. The levels of inflammatory factors, stress hormones and immune function were compared in two groups before and after treatment.Results: Before treatment, there was no significant difference in the levels of neutrophile granulocyte, CRP, WBC, COR, E, CD3+, CD4+, CD8+ and NK cells between the two groups. After treatment, the levels of CD3+, CD4+ and NK cells in the observation group were significantly higher than those in the control group, moreover, these levels after treatment were obviously lower than before treatment;The levels of neutrophile granulocyte, CRP, WBC, COR, E and CD8+ in the observation group were significantly lower than those in the control group, and these levels were significantly higher than before treatment.Conclusion: Compared with partial open hepatectomy, laparoscopic normal hepatectomy can effectively reduce the inflammatory factors and stress hormone levels, improve the immune function of the body, and have a certain clinical value.

Effects of Xiaocangping tablets combined with 5-fluorouracil and cisplatin on immunity, tumor markers, angiogenesis and related factors in patients with advanced esophageal cancer

Objective:To explore the effects of Xiaocangping tablets combined with 5-fluorouracil and cisplatin on immunity, tumor markers, angiogenesis and related factors in patients with advanced esophageal cancer.Methods:86 patients with advanced esophageal cancer admitted to our hospital from March 2014 to February 2017 were randomly divided into control group (43 cases) and observation group (43 cases). All the subjects were treated with 5-fluorouracil plus cisplatin, and the observation group was treated with Xiaocangping tablets on this basis. The changes of immune function, tumor markers, angiogenesis and related factors in the two groups were compared and analyzed.Results:After treatment, the levels of CD4+, CD4+/CD8 + in both groups were significantly higher than those before treatment (P<0.05), while the levels of CD8+ were significantly lower than those before treatment (P<0.05), the levels of CD4+ and CD4+/CD8+ in the observation group were significantly higher than those in the control group (P<0.05), while the levels of CD8+ in the observation group was significantly lower than that in the control group (P<0.05);the levels of CA125, CEA and CA19-9 in the two groups were significantly lower than those before treatment (P<0.05), and the levels of CA125, CEA and CA19-9 in the observation group were significantly lower than those in the control group (P<0.05);the levels of VEGF, TGF-β1, MMP-9, NGAL in the two groups were significantly lower than those before treatment (P<0.05), and the levels of VEGF, TGF-β1, MMP-9, NGAL in the observation group were significantly lower than the control group (P<0.05).Conclusions:Chemotherapy combined with fluorouracil + cisplatin chemotherapy for advanced esophageal cancer can effectively improve the immune function of patients, reduce the level of tumor markers, inhibit the proliferation of tumor blood vessels, and have significant anti-cancer effects, which is of positive significance for controlling the development of patients' conditions.

Effects of laparoscopic hepatectomy and laparoscopic radiofrequency ablation on immune function, pain related indexes and liver function in patients with hepatocellular carcinoma

Objective:To investigate the effects of laparoscopic hepatectomy and laparoscopic radiofrequency ablation on immune function, pain related indexes and liver function in patients with hepatocellular carcinoma.Methods: Ninety-six patients with hepatocellular carcinoma were randomly divided into two groups: control group and observation group. The patients in the control group were treated with laparoscopic hepatectomy, and the patients in the observation group were treated with laparoscopic radiofrequency ablation. The immune function, pain index and liver function were compared between the two groups.Results:There was no significant difference in the levels of CD3+, CD4+, CD8+, CD4+/CD8+, COR, NE, CRP, ALT and AST in two groups before treatment. After treatment, the levels of CD3+, CD4+and CD4+/CD8+ in the observation group were significantly higher than those in the control group. The levels of CD8+, COR, NE, CRP, ALT and AST in the observation group were significantly lower than those in the control group.Conclusion: Compared with laparoscopic hepatectomy, laparoscopic radiofrequency ablation for hepatocellular carcinoma can improve the immune function and liver function, reduce pain, and has certain clinical value.

Effects of laparoscopic minimally invasive surgery on coagulation, antioxidant function, angiogenesis, IGF-1 and IFN-γ levels in rectal cancer patients

Objective: To investigate the effects of laparoscopic minimally invasive surgery on coagulation, antioxidant function, angiogenesis, IGF-1 and IFN-γ levels in rectal cancer patients. Methods: A total of 90 patients with rectal cancer admitted to general surgery in our hospital from March 2016 to December 2017 were randomly divided into control group (n=45) and observation group (n=45), the control group underwent conventional open surgery and the observation group underwent laparoscopic radical resection. The blood coagulation function, antioxidant capacity, angiogenesis, IGF-1 and IFN-γ levels were compared between the two groups. Results: Before treatment, there was no significant difference in coagulation function, antioxidant capacity, angiogenesis, IGF-1 and IFN-γ levels between the two groups. After treatment, there was no significant difference in PT and APTT between the two groups, while FIB and DD were significantly increased compared with before treatment, and the FIB and DD of the observation group increased significantly compared with the control group;the SOD and GSH of the two groups were significantly lower than those before treatment, while the MDA was significantly increased compared with that before treatment, the decrease of SOD, GSH and the increase of MDA in the observation group was significantly greater than that of the control group;the levels of VEGF and MMP-9 in the two groups were significantly lower than those before treatment, and the VEGF and MMP-9 in the observation group were significantly lower than those in the control group;the levels of IGF-1 in the two groups were significantly lower than those before treatment, and the IGF-1 in the observation group was significantly lower than that in the control group;the IFN-γ levels in the two groups were significantly higher than those before treatment, and the IFN-γ was significantly increased in the observation group compared with the control group. Conclusions: Laparoscopic surgery for patients with rectal cancer can easily cause hypercoagulable state of the patient's blood, but it can effectively avoid tumor metastasis and less stress damage, and further promote the rehabilitation of the patients, which is worthy of clinical promotion.

Effect of radical gastrectomy for stress and immune function in patients with cardiac cancer

Objective: To investigate the effects of abdominal and transthoracic surgery on perioperative stress and immune function in patients with cardiac cancer. Methods: 60 patients with cardiac cancer treated in our hospital from May 2016 to October 2017 were collected. According to the different surgical methods, they were divided into the transthoracic group and the abdominal group, with 30 cases in each group. The changes of inflammatory factors, T-lymphocyte subsets, NK cells, immune globulin, and oxidative stress parameters were compared between the two groups before and 7 d after surgery. Result: There were no significant differences in preoperative inflammatory factors, T lymphocyte subsets, NK cells, immunoglobulins, and oxidative stress between the two groups. At 7 d after surgery, COR and CRP levels increased in both groups, but COR and CRP levels in abdominal group were (63.03±5.31) mg/L and (245.15±22.88) ng/L which were lower than those in transthoracic group. The levels of CD4+,CD4+/CD8+and CD8+ and NK were significantly increased in both groups after operation, and CD4+ and CD4+/CD8+ were (34.23±3.42)% and (1.22±0.12), which were higher than those in the transabdominal group. While the number of CD8+ and NK cells in the group was (28.12±2.91)% and (19.11±1.92)% respectively, which were lower than those in the transthoracic group. The levels of IgA, IgG, and IgM were significantly reduced in both groups after operation, and IgA, IgG, and IgM were (2.84±0.27) g/L, (12.11±1.20) g/L, and (1.46±0.15) g/L respectively, which were higher than those in the transabdominal group. MDA levels in both groups were increased, while SOD levels in both groups were decreased. However, the MDA in the abdominal group was (5.27±0.53) mmol/mL wiche were lower than that in the transthoracic group, and the SOD was (80.26±8.06) U/mL which wewe higher than that in the transthoracic group. Conclusion: The radical gastrectomy can reduce inflammatory stress and oxidative stress in patients with cardiac cancer and protect immune function.