A stable and commercially available reagent mixture,composed of tetrabutylammonium bifluoride/potassium bifluoride（TBAF/KHF_2）,was found to be effective for the nucleophilic ring opening reactions of sugar-derived e...A stable and commercially available reagent mixture,composed of tetrabutylammonium bifluoride/potassium bifluoride（TBAF/KHF_2）,was found to be effective for the nucleophilic ring opening reactions of sugar-derived epoxides with fluoride.Different sugar-derived epoxide precursors,including 1-thioglycosides can be ring-opened to afford fluorinated carbohydrate products in high yields and in short reaction times.展开更多
基金the National Natural Science Foundation of China (No. 21502076) for the financial support
文摘A stable and commercially available reagent mixture,composed of tetrabutylammonium bifluoride/potassium bifluoride（TBAF/KHF_2）,was found to be effective for the nucleophilic ring opening reactions of sugar-derived epoxides with fluoride.Different sugar-derived epoxide precursors,including 1-thioglycosides can be ring-opened to afford fluorinated carbohydrate products in high yields and in short reaction times.
