BACKGROUND Gastric cancer(GC)is the fifth most common and the fourth most lethal malignant tumour in the world.Most patients are already in the advanced stage when they are diagnosed,which also leads to poor overall s...BACKGROUND Gastric cancer(GC)is the fifth most common and the fourth most lethal malignant tumour in the world.Most patients are already in the advanced stage when they are diagnosed,which also leads to poor overall survival.The effect of posto-perative adjuvant chemotherapy for advanced GC is unsatisfactory with a high rate of distant metastasis and local recurrence.AIM To investigate the safety and efficacy of a programmed cell death 1(PD-1)inhibitor combined with oxaliplatin and S-1(SOX)in the treatment of Borrmann large type III and IV GCs.METHODS A retrospective analysis(IRB-2022-371)was performed on 89 patients with Borrmann large type III and IV GCs who received neoadjuvant therapy(NAT)from January 2020 to December 2021.According to the different neoadjuvant treatment regimens,the patients were divided into the SOX group(61 patients)and the PD-1+SOX(P-SOX)group(28 patients).RESULTS The pathological response(tumor regression grade 0/1)in the P-SOX group was significantly higher than that in the SOX group(42.86%vs 18.03%,P=0.013).The incidence of ypN0 in the P-SOX group was higher than that in the SOX group(39.29%vs 19.67%,P=0.05).The use of PD-1 inhibitors was an independent factor affecting tumor regression grade.Meanwhile,the use of PD-1 did not increase postoperative complications or the adverse effects of NAT.CONCLUSION A PD-1 inhibitor combined with SOX could significantly improve the rate of tumour regression during NAT for patients with Borrmann large type III and IV GCs.展开更多
ZnSe as a surface passivation layer in quantum dot-sensitized solar cells plays an important role in preventing charge recombination and thus improves the power conversion efficiency(PCE).However, as a wide bandgap se...ZnSe as a surface passivation layer in quantum dot-sensitized solar cells plays an important role in preventing charge recombination and thus improves the power conversion efficiency(PCE).However, as a wide bandgap semiconductor, ZnSe cannot efficiently absorb and convert long-wavelength light.Doping transition metal ions into ZnSe semiconductors is an effective way to adjust the band gap, such as manganese ions.In this paper, it is found by the method of density functional theory calculation that the valence band of ZnSe moves upward with manganese ions doping, which leads to acceleration of charge separation, wider light absorption range, and enhancing light harvesting.Finally, by using ZnSe doped with manganese ions as the passivation layer, the TiO2/CdS/CdSe co-sensitized solar cell has a PCE of 6.12%, and the PCE of the solar cell increases by 9% compared with the undoped one(5.62%).展开更多
基金Supported by Medical Science and Technology Project of Zhejiang Province(2022KY085).
文摘BACKGROUND Gastric cancer(GC)is the fifth most common and the fourth most lethal malignant tumour in the world.Most patients are already in the advanced stage when they are diagnosed,which also leads to poor overall survival.The effect of posto-perative adjuvant chemotherapy for advanced GC is unsatisfactory with a high rate of distant metastasis and local recurrence.AIM To investigate the safety and efficacy of a programmed cell death 1(PD-1)inhibitor combined with oxaliplatin and S-1(SOX)in the treatment of Borrmann large type III and IV GCs.METHODS A retrospective analysis(IRB-2022-371)was performed on 89 patients with Borrmann large type III and IV GCs who received neoadjuvant therapy(NAT)from January 2020 to December 2021.According to the different neoadjuvant treatment regimens,the patients were divided into the SOX group(61 patients)and the PD-1+SOX(P-SOX)group(28 patients).RESULTS The pathological response(tumor regression grade 0/1)in the P-SOX group was significantly higher than that in the SOX group(42.86%vs 18.03%,P=0.013).The incidence of ypN0 in the P-SOX group was higher than that in the SOX group(39.29%vs 19.67%,P=0.05).The use of PD-1 inhibitors was an independent factor affecting tumor regression grade.Meanwhile,the use of PD-1 did not increase postoperative complications or the adverse effects of NAT.CONCLUSION A PD-1 inhibitor combined with SOX could significantly improve the rate of tumour regression during NAT for patients with Borrmann large type III and IV GCs.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.61376011,61704114,51402141,and 61604086)the Gansu Provincial Natural Science Foundation,China(Grant No.17JR5RA198)+2 种基金the Fundamental Research Funds for the Central Universities,China(Grant Nos.lzujbky-2018-119 and lzujbky-2018-ct08)the Fund from Shenzhen Science and Technology Innovation Committee,China(Grant No.JCYJ20170818155813437)the Key Areas Scientific and Technological Research Projects in Xinjiang Production and Construction Corps(Grant No.2018AB004)
文摘ZnSe as a surface passivation layer in quantum dot-sensitized solar cells plays an important role in preventing charge recombination and thus improves the power conversion efficiency(PCE).However, as a wide bandgap semiconductor, ZnSe cannot efficiently absorb and convert long-wavelength light.Doping transition metal ions into ZnSe semiconductors is an effective way to adjust the band gap, such as manganese ions.In this paper, it is found by the method of density functional theory calculation that the valence band of ZnSe moves upward with manganese ions doping, which leads to acceleration of charge separation, wider light absorption range, and enhancing light harvesting.Finally, by using ZnSe doped with manganese ions as the passivation layer, the TiO2/CdS/CdSe co-sensitized solar cell has a PCE of 6.12%, and the PCE of the solar cell increases by 9% compared with the undoped one(5.62%).