Background：Diabetes mellitus （DM） remains a major health problem worldwide.Several clinical trials have shown the superiority of the Traditional Chinese Medicine in delaying or reversing the development and progres...Background：Diabetes mellitus （DM） remains a major health problem worldwide.Several clinical trials have shown the superiority of the Traditional Chinese Medicine in delaying or reversing the development and progression of DM.This study aimed to evaluate the efficacy of Jinlida （JLD） granule,a Chinese herbal recipe,in the treatment of impaired glucose tolerance （IGT） and its effect on the prevention of DM.Methods：Sixty-five IGT patients were randomized to receive one bag of JLD granules three times daily （JLD group,n =34） or no drug intervention （control group,n =31） for 12 weeks.Oral glucose tolerance test,glycated hemoglobin A1c （HbA1c）,body mass index,blood lipids levels,fasting insulin,and insulin resistance calculated using homeostatic model assessment （HOMA-IR） of all the patients were observed and compared before and after the treatment.Results：Sixty-one participants completed the trial （32 in JLD group and 29 in the control group）.There were statistically significant decreases in HbA1c （P 〈 0.001）,2-h plasma glucose （P 〈 0.001）,and HOMA-IR （P =0.029） in JLD group compared with the control group after 12 weeks of treatment.After 12 weeks of treatment,two （6.9%） patients returned to normal blood glucose,and five （17.2%） patients turned into DM in control group,while in the JLD group,14 （43.8%） returned to normal blood glucose and 2 （6.2%） turned into DM.There was a significant difference in the number of subjects who had normal glucose at the end of the study between two groups （P =0.001）.Conclusions：JLD granule effectively improved glucose control,increased the conversion of IGT to normal glucose,and improved the insulin resistance in patients with IGT.This Chinese herbal medicine may have a clinical value for IGT.展开更多
The mortality rate of severe coronavirus disease 2019(COVID-19)is high,and there is no universally accepted method to predict its occurrence.COVID-19 pneumonia can be classified into four categories,such as,asymptomat...The mortality rate of severe coronavirus disease 2019(COVID-19)is high,and there is no universally accepted method to predict its occurrence.COVID-19 pneumonia can be classified into four categories,such as,asymptomatic,mild,moderate,and severe.According to Wu et al.1 data regarding COVID-19 patients in China's Mainland showed that among 44,415 patients who suffered from COVID-19,36,160 patients had mild COVID-19.展开更多
Exposure to airborne particulate matters(fine particulate matter[PM2.5]and inhalable particulate matter[PM10])causes acute exacerbation of chronic respiratory diseases and even death in some patients.[1,2]Here,we stud...Exposure to airborne particulate matters(fine particulate matter[PM2.5]and inhalable particulate matter[PM10])causes acute exacerbation of chronic respiratory diseases and even death in some patients.[1,2]Here,we studied the association between airborne pollutants(PM2.5,PM10,ozone[O_(3)]),weather conditions(mean air temperature,wind force),and outpatient and inpatient visits for chronic respiratory diseases(bronchitis,emphysema and chronic obstructive pulmonary disease[COPD],bronchiectasis)in Xiamen,China.展开更多
基金Project(2017JJ3359)supported by the Natural Science Foundation of Hunan Province,ChinaProject(KFJJ13-11M)supported by the Opening Project of State Key Laboratory of Explosion Science and Technology(Beijing Institute of Technology),China.
文摘Background：Diabetes mellitus （DM） remains a major health problem worldwide.Several clinical trials have shown the superiority of the Traditional Chinese Medicine in delaying or reversing the development and progression of DM.This study aimed to evaluate the efficacy of Jinlida （JLD） granule,a Chinese herbal recipe,in the treatment of impaired glucose tolerance （IGT） and its effect on the prevention of DM.Methods：Sixty-five IGT patients were randomized to receive one bag of JLD granules three times daily （JLD group,n =34） or no drug intervention （control group,n =31） for 12 weeks.Oral glucose tolerance test,glycated hemoglobin A1c （HbA1c）,body mass index,blood lipids levels,fasting insulin,and insulin resistance calculated using homeostatic model assessment （HOMA-IR） of all the patients were observed and compared before and after the treatment.Results：Sixty-one participants completed the trial （32 in JLD group and 29 in the control group）.There were statistically significant decreases in HbA1c （P 〈 0.001）,2-h plasma glucose （P 〈 0.001）,and HOMA-IR （P =0.029） in JLD group compared with the control group after 12 weeks of treatment.After 12 weeks of treatment,two （6.9%） patients returned to normal blood glucose,and five （17.2%） patients turned into DM in control group,while in the JLD group,14 （43.8%） returned to normal blood glucose and 2 （6.2%） turned into DM.There was a significant difference in the number of subjects who had normal glucose at the end of the study between two groups （P =0.001）.Conclusions：JLD granule effectively improved glucose control,increased the conversion of IGT to normal glucose,and improved the insulin resistance in patients with IGT.This Chinese herbal medicine may have a clinical value for IGT.
基金This work was supported by the grants from National Natural Science Foundation of China(grant number 81772266)Natural Science Foundation of Guangdong Province(grant number 2017A030311014).We sincerely thank all collaborators who contributed to this study.We sincerely thank all patients and healthy volunteers for participating in this study。
文摘The mortality rate of severe coronavirus disease 2019(COVID-19)is high,and there is no universally accepted method to predict its occurrence.COVID-19 pneumonia can be classified into four categories,such as,asymptomatic,mild,moderate,and severe.According to Wu et al.1 data regarding COVID-19 patients in China's Mainland showed that among 44,415 patients who suffered from COVID-19,36,160 patients had mild COVID-19.
基金Project supported by the National Key Basic Research Program(973)of China(No.2012CB725400)the National High-Tech R&D Program(863)of China(No.2012AA112304)the National Natural Science Foundation of China(No.51338003)
基金supported by the grants from the National Key Research and Development Program of China(No.2018YFC1313602)Major International(Regional)Joint Research Project(No.81820108001)+4 种基金National Natural Science Foundation of China(No.81670029)Jiangsu Key Principal Investigator of Medicine(No.ZDRCA2016018)Project 333 for Cultivation of Young and Middle-aged Leading Talents(No.BRA2019078)Jiangsu Key Program of Social Development(No.BE2015651)Nanjing Key Project of Science and Technology(No.2019060002).
文摘Exposure to airborne particulate matters(fine particulate matter[PM2.5]and inhalable particulate matter[PM10])causes acute exacerbation of chronic respiratory diseases and even death in some patients.[1,2]Here,we studied the association between airborne pollutants(PM2.5,PM10,ozone[O_(3)]),weather conditions(mean air temperature,wind force),and outpatient and inpatient visits for chronic respiratory diseases(bronchitis,emphysema and chronic obstructive pulmonary disease[COPD],bronchiectasis)in Xiamen,China.
