Individualized anti-thrombotic therapy for acute myocardial infarction complicated with left ventricular thrombus: A case report

BACKGROUND Presently,there is no established standard anti-blood clot therapy for patients facing acute myocardial infarction(AMI)complicated by left ventricular thrombus(LVT).While vitamin K antagonists are the preferred choice for oral blood thinning,determining the best course of blood-thinning medication remains challenging.It is unclear if non-vitamin K antagonist oral blood thinners have different effectiveness in treating LVT.This study significantly contributes to the medical community.CASE SUMMARY The blood-thinning treatment of a patient with AMI and LVT was analyzed.Triple blood-thinning therapy included daily enteric-coated aspirin tablets at 0.1 g,daily clopidogrel hydrogen sulfate at 75 mg,and dabigatran etexilate at 110 mg twice daily.After 15 d,the patient’s LVT did not decrease but instead increased.Clinical pharmacists comprehensively analyzed the cases from the perspective of the patient’s disease status and drug interaction.The drug regimen was reformulated for the patient,replacing dabigatran etexilate with warfarin,and was administered for six months.The clinical pharmacist provided the patient with professional and standardized pharmaceutical services.The patient’s condition was discharged after meeting the international normalized ratio value(2-3)criteria.The patient fully complied with the follow-up,and the time in the therapeutic range was 78.57%,with no serious adverse effects during pharmaceutical monitoring.CONCLUSION Warfarin proves to be an effective drug for patients with AMI complicated by LVT,and its blood-thinning course lasts for six months.

Formation of novel TRIP-ductilized bulk metallic glass composites by manipulating nucleation kinetics via minor alloying

A series of conical bulk metallic glass composites(BMGCs)with compositions of Zr_(47)Cu_(47-x)Al_(5)Ag_(1)Ga_(x)(x=0,1,2,4;at%)were synthesized using the minor alloying method to investigate the effect of Ga addition on the glass-forming ability(GFA),micro structure uniformity and mechanical properties.

Amorphous FeNiCoCuSiBCr Alloys with Superior Direct Current Tolerant Characteristics

Amorphous Fe62-x Ni19CoxCu0.1 Si3.8B14Cr1. 1 （x=0, 1, 5, 10） ribbons were annealed under magnetic field and tensile stress, respectively, and their magnetic properties were investigated. Fe73.5 Cu1 Nb3 Si15.5 B7 and Fe66 Ni10- Cu1 Nb3Si11 B9 nanocrystalline alloy ribbons were also fabricated for comparison. Excellent DC tolerant property was obtained in the amorphous FeNiCoCuSiBCr ribbons after thermomagnetic treatment and the constant permeable property was improved with increasing Co content. The relative permeability was constant up to the DC bias field of approximately 6 ×10 ^-4 , 9 ×10 ^-4, and 10 × 10^-4 T and the values of relative permeability μ were 1 650, 1 200, and 1 000 with the Co content being 0, 5 at. %, and 10 at.%, respectively. Besides, stress-annealed FeNiCoCuSiBCr al- loy ribbons were proved to exhibit positive saturation magnetostriction constant λs.

Effect of Heat Treatment on Corrosion Behaviour of Amorphous Metal Fibers

Amorphous metal fiber has high corrosion resistance and excellent mechanical properties, making it a kind of good material for reinforcing concrete matrix. The effect of heat treatment on the corrosion behaviour of Fe73- Cr6C9Si1P11 amorphous metal fibers in 0.5 mol/L He SO4 solution was investigated by electrochemical polarization analysis. Differential scanning calorimetry （DSC） was used to measure the thermal properties. The evolution of the crystallization process after heat treatment was identified by X-ray diffraction （XRD）. The results show that the α- Fe, Fe2 P and Fea P crystalline phases individually precipitate in the amorphous matrix with increasing annealing temperature. The as prepared amorphous sample shows high corrosion resistance with a lower passivation current density and a wider passive region. The corrosion resistance dramatically decreases after the annealing temperature is higher than 400 ℃.

Magnetic Properties of FeSiBC Amorphous Alloy Powder Cores Using Mechanical-crushed Powder

The FeSiBC amorphous powder cores were fabricated using powders of the FeSiBC amorphous ribbons which were mechanically crushed for a short time, and the relationship between magnetic properties and powder particle sizes was evaluated. The saturation magnetization Bs of the amorphous Fe82Si2B15C1 alloy was 1.62 T, which provided a superior dc-bias property for the powder cores. Meanwhile, a stable permeability up to high frequency range over 10 MHz and the low core loss of 400 kW/ma at f=50 kHz and Bm =0.1 T were obtained. These excellent high-frequency magnetic properties of the FeSiBC amorphous powder cores could be attributed to the effective electrical insulation between the FeSiBC amorphous powders made by mechanical crushing.

Fe-based multi-phase nanocrystalline ribbons with hierarchically flowerlike structured metal oxides after modified by Orange II for Cr^VI absorption

Three-dimensional flowerlike nanostructured metal oxides attached on the surfaces of Fe-based multi-phase nanocrys- talline ribbons （Fe-MNRs） were prepared by a simple way （through immersing the Fe-MNRs in Orange II solution）. It has been found that the as-prepared Fe-MNRs with 3D flowerlike nanostructures （Fe-MNRs ＋ FNs） exhibit good absorption property for a typical heavy metal ion （Cr^VI） in wastewater, while Fe-MNRs do not possess such properties. The Fe-MNRs ＋ FNs could remove 99% CrvI ions from the solution in 40 min, and this adsorption property can be attributed to the ion exchange between Cr^VI and surface hydroxyl groups （O-H） of 3D flowerlike nanostructures. The present result suggests that the Fe-MNRs ＋ FNs, prepared by facile way, possess great potentials in removing heavy metallic ions in wastewater.

Magnetic Properties of Nanocrystalline Powder Cores Fabricated by Mechanically Crushed Powders

Fe73. 5 Cu1 Nb3 Si15.5B7 nanocrystalline powder cores with different particle sizes ranging from 10 to 125 9m were fabricated by cold-pressing techniques. The cores exhibited increased core loss P cv and decreased initial permea- bility μi with addition of fine powders below 50 μm in size, and the content should be less than 40 mass%. It was thought to be closely related to the high coercive force H c due to the stresses generated during the crushing process and high demagnetization fields of small powders. Furthermore, modifying the alloy compositions by adding defined amount of Ni could improve the soft magnetic properties, including superior characteristics of permeability under high direct current （DC） bias field and comparable low core loss at high frequency.

Magnetic Properties of Nanocrystalline Powder Cores Using Mechanically Crushed Powders

Toroidal shape FeCuNbSiB nanocrystalline alloy powder cores were prepared by cold pressing using me- chanically crushed and ball-milled powders, respectively. The morphologies and their effects on the magnetic proper- ties of the compacted cores were investigated. Compared with ball-milled powders, mechanically crushed ones have more regular shapes and rounder edges, which lead to better inter-particle insulation. FeCuNbSiB nanocrystalline al- loy powder cores fabricated from mechanically crushed powders exhibit remarkably lower core loss of about 248.2 kW/m3 at 100 kHz for maximum flux density Bm 0.1 T, and more stable permeability up to 10 MHz. Moreover, the dc-bias property could be improved significantly using mechanically crushed powders.