BACKGROUND Individuals diagnosed with gastrointestinal tumors are at an increased risk of developing cardiovascular diseases.Among which,ventricular arrhythmia is a prevalent clinical concern.This suggests that ventri...BACKGROUND Individuals diagnosed with gastrointestinal tumors are at an increased risk of developing cardiovascular diseases.Among which,ventricular arrhythmia is a prevalent clinical concern.This suggests that ventricular arrhythmias may have predictive value in the prognosis of patients with gastrointestinal tumors.AIM To explore the prognostic value of ventricular arrhythmias in patients with gastrointestinal tumors receiving surgery.METHODS We retrospectively analyzed data from 130 patients undergoing gastrointestinal tumor resection.These patients were evaluated by a 24-h ambulatory electrocardiogram(ECG)at the Sixth Affiliated Hospital of Sun Yat-sen University from January 2018 to June 2020.Additionally,41 general healthy age-matched and sexmatched controls were included.Patients were categorized into survival and non-survival groups.The primary endpoint was all-cause mortality,and secondary endpoints included major adverse cardiovascular events(MACEs).RESULTS Colorectal tumors comprised 90%of cases.Preoperative ambulatory ECG monitoring revealed that among the 130 patients with gastrointestinal tumors,100(76.92%)exhibited varying degrees of premature ventricular contractions(PVCs).Ten patients(7.69%)manifested non-sustained ventricular tachycardia(NSVT).The patients with gastrointestinal tumors exhibited higher PVCs compared to the healthy controls on both conventional ECG[27(21.3)vs 1(2.5),P=0.012]and 24-h ambulatory ECG[14(1.0,405)vs 1(0,6.5),P<0.001].Non-survivors had a higher PVC count than survivors[150.50(7.25,1690.50)vs 9(0,229.25),P=0.020].During the follow-up period,24 patients died and 11 patients experienced MACEs.Univariate analysis linked PVC>35/24 h to all-cause mortality,and NSVT was associated with MACE.However,neither PVC burden nor NSVT independently predicted outcomes according to multivariate analysis.CONCLUSION Patients with gastrointestinal tumors exhibited elevated PVCs.PVCs>35/24 h and NSVT detected by 24-h ambulatory ECG were prognostically significant but were not found to be independent predictors.展开更多
BACKGROUND The causality between education and type 2 diabetes(T2DM)remains unclear.AIM To identify the causality between education and T2DM and the potential metabolic risk factors[coronary heart disease(CHD),total c...BACKGROUND The causality between education and type 2 diabetes(T2DM)remains unclear.AIM To identify the causality between education and T2DM and the potential metabolic risk factors[coronary heart disease(CHD),total cholesterol,lowdensity lipoprotein,triglycerides(TG),body mass index(BMI),waist circumference(WC),waist-to-hip ratio(WHR),fasting insulin,fasting glucose,and glycated hemoglobin]from summarized genome-wide association study(GWAS)data used a network Mendelian randomization(MR).METHODS Two-sample MR and network MR were performed to obtain the causality between education-T2DM,education-mediator,and mediator-T2DM.Summary statistics from the Social Science Genetic Association Consortium(discovery data)and Neale Lab consortium(replication data)were used for education and DIAGRAMplusMetabochip for T2DM.RESULTS The odds ratio for T2DM was 0.392(95%CI:0.263-0.583)per standard deviation increase(3.6 years)in education by the inverse variance weighted method,without heterogeneity or horizontal pleiotropy.Education was genetically associated with CHD,TG,BMI,WC,and WHR in the discovery phase,yet only the results for CHD,BMI,and WC were replicated in the replication data.Moreover,BMI was genetically associated with T2DM.CONCLUSION Short education was found to be associated with an increased T2DM risk.BMI might serve as a potential mediator between them.展开更多
The C-I bond dissociation enthalpies (BDE) of various organic iodides were calculated using high-level theoretical methods including MP2 and CCSD(T) with extrapolated basis set as well as a number of density funct...The C-I bond dissociation enthalpies (BDE) of various organic iodides were calculated using high-level theoretical methods including MP2 and CCSD(T) with extrapolated basis set as well as a number of density functional theory methods. After systematic evaluation of the theoretical results against available experimental C-I BDEs, it was found that the MPW LYPIM method gave the lowest root mean square error. We, therefore, used this method to examine the substituent effects on different categories of C(sp3)-I and C(sp2)-I bonds. Fur thermore, the remote substituent effects on the C-I BDEs of substituted iodobenzenes and substituted (iodomethyl)benzenes were also investigated at the same level. The C-I BDEs of typical heteroaromatic iodides including five-membered and six-membered heterocyclic iodides were also examined.展开更多
基金Supported by the Sixth Affiliated Hospital of Sun Yat-sen University Clinical Research-1010 Program,No.1010PY(2023)-06the National Nature Science Foundation of China,No.81400301+1 种基金the Fundamental Research Funds for the Central Universities,No.19ykpy10Guangzhou Health Science and Technology Project,No.20231A010068.
文摘BACKGROUND Individuals diagnosed with gastrointestinal tumors are at an increased risk of developing cardiovascular diseases.Among which,ventricular arrhythmia is a prevalent clinical concern.This suggests that ventricular arrhythmias may have predictive value in the prognosis of patients with gastrointestinal tumors.AIM To explore the prognostic value of ventricular arrhythmias in patients with gastrointestinal tumors receiving surgery.METHODS We retrospectively analyzed data from 130 patients undergoing gastrointestinal tumor resection.These patients were evaluated by a 24-h ambulatory electrocardiogram(ECG)at the Sixth Affiliated Hospital of Sun Yat-sen University from January 2018 to June 2020.Additionally,41 general healthy age-matched and sexmatched controls were included.Patients were categorized into survival and non-survival groups.The primary endpoint was all-cause mortality,and secondary endpoints included major adverse cardiovascular events(MACEs).RESULTS Colorectal tumors comprised 90%of cases.Preoperative ambulatory ECG monitoring revealed that among the 130 patients with gastrointestinal tumors,100(76.92%)exhibited varying degrees of premature ventricular contractions(PVCs).Ten patients(7.69%)manifested non-sustained ventricular tachycardia(NSVT).The patients with gastrointestinal tumors exhibited higher PVCs compared to the healthy controls on both conventional ECG[27(21.3)vs 1(2.5),P=0.012]and 24-h ambulatory ECG[14(1.0,405)vs 1(0,6.5),P<0.001].Non-survivors had a higher PVC count than survivors[150.50(7.25,1690.50)vs 9(0,229.25),P=0.020].During the follow-up period,24 patients died and 11 patients experienced MACEs.Univariate analysis linked PVC>35/24 h to all-cause mortality,and NSVT was associated with MACE.However,neither PVC burden nor NSVT independently predicted outcomes according to multivariate analysis.CONCLUSION Patients with gastrointestinal tumors exhibited elevated PVCs.PVCs>35/24 h and NSVT detected by 24-h ambulatory ECG were prognostically significant but were not found to be independent predictors.
基金the National Natural Science Foundation of China,No.81701378.
文摘BACKGROUND The causality between education and type 2 diabetes(T2DM)remains unclear.AIM To identify the causality between education and T2DM and the potential metabolic risk factors[coronary heart disease(CHD),total cholesterol,lowdensity lipoprotein,triglycerides(TG),body mass index(BMI),waist circumference(WC),waist-to-hip ratio(WHR),fasting insulin,fasting glucose,and glycated hemoglobin]from summarized genome-wide association study(GWAS)data used a network Mendelian randomization(MR).METHODS Two-sample MR and network MR were performed to obtain the causality between education-T2DM,education-mediator,and mediator-T2DM.Summary statistics from the Social Science Genetic Association Consortium(discovery data)and Neale Lab consortium(replication data)were used for education and DIAGRAMplusMetabochip for T2DM.RESULTS The odds ratio for T2DM was 0.392(95%CI:0.263-0.583)per standard deviation increase(3.6 years)in education by the inverse variance weighted method,without heterogeneity or horizontal pleiotropy.Education was genetically associated with CHD,TG,BMI,WC,and WHR in the discovery phase,yet only the results for CHD,BMI,and WC were replicated in the replication data.Moreover,BMI was genetically associated with T2DM.CONCLUSION Short education was found to be associated with an increased T2DM risk.BMI might serve as a potential mediator between them.
文摘The C-I bond dissociation enthalpies (BDE) of various organic iodides were calculated using high-level theoretical methods including MP2 and CCSD(T) with extrapolated basis set as well as a number of density functional theory methods. After systematic evaluation of the theoretical results against available experimental C-I BDEs, it was found that the MPW LYPIM method gave the lowest root mean square error. We, therefore, used this method to examine the substituent effects on different categories of C(sp3)-I and C(sp2)-I bonds. Fur thermore, the remote substituent effects on the C-I BDEs of substituted iodobenzenes and substituted (iodomethyl)benzenes were also investigated at the same level. The C-I BDEs of typical heteroaromatic iodides including five-membered and six-membered heterocyclic iodides were also examined.