Differences in Non-suicidal Self-injury Behaviors between Unipolar Depression and Bipolar Depression in Adolescent Outpatients

Objective Non-suicidal self-injury(NSSI)has a higher prevalence in adolescents with depressive disorders than in community adolescents.This study examined the differences in NSSI behaviors between adolescents with unipolar depression(UD)and those with bipolar depression(BD).Methods Adolescents with UD or BD were recruited from 20 general or psychiatric hospitals across China.The methods,frequency,and function of NSSI were assessed by Functional Assessment of Self-Mutilation.The Beck Suicide Ideation Scale was used to evaluate adolescents’suicidal ideation,and the 10-item Kessler Psychological Distress Scale to estimate the anxiety and depression symptoms.Results The UD group had higher levels of depression(19.16 vs.17.37,F=15.23,P<0.001)and anxiety symptoms(17.73 vs.16.70,F=5.00,P=0.026)than the BD group.Adolescents with BD had a longer course of NSSI than those with UD(2.00 vs.1.00 year,Z=−3.39,P=0.001).There were no statistical differences in the frequency and the number of methods of NSSI between the UD and BD groups.Depression(r=0.408,P<0.01)and anxiety(r=0.391,P<0.01)were significantly and positively related to NSSI frequency.Conclusion Adolescents with BD had a longer course of NSSI than those with UD.More importantly,NSSI frequency were positively and strongly correlated with depression and anxiety symptoms,indicating the importance of adequate treatment of depression and anxiety in preventing and intervening adolescents’NSSI behaviors.

Misdiagnosis of food-borne foreign bodies outside of the digestive tract on magnetic resonance imaging:Two case reports

BACKGROUND Patients with foreign bodies in the digestive tract are often encountered,but complete penetration of a foreign body through the gastrointestinal tract is rare,and the choice of imaging method is very important.Improper selection may lead to missed diagnosis or misdiagnosis.CASE SUMMARY An 81-year-old man was diagnosed as having a liver malignancy after he took magnetic resonance imaging and positron emission tomography/computed tomography(CT)examinations.The pain improved after the patient accepted gamma knife treatment.However,he was admitted to our hospital 2 mo later due to fever and abdominal pain.This time,he received a contrast-enhanced CT scan,which showed fish-boon-like foreign bodies in the liver with peripheral abscess formation,then he went to the superior hospital for surgery.It lasted for more than 2 mo from the onset of the disease to the surgical treatment.A 43-year-old woman with a 1 mo history of a perianal mass with no obvious pain or discomfort was diagnosed as having an anal fistula with the formation of a local small abscess cavity.Clinical perianal abscess surgery was performed,and fish bone foreign body was found in perianal soft tissue during the operation.CONCLUSION For patients with pain symptoms,the possibility of foreign body perforation should be considered.Magnetic resonance imaging is not comprehensive and that a plain computed tomography scan of the pain area is necessary.

Cardiac amyloidosis presenting as pulmonary arterial hypertension:A case report

BACKGROUND Pulmonary hypertension is a rare cardiopulmonary disease,with an insidious onset that usually worsens rapidly.Amyloid light chain(AL)amyloidosis is a rare systemic disease caused by extracellular deposition of pathologic,insoluble,and proteinaceous fibrils in organs and tissues;however,it is difficult to diagnose given its varied and nonspecific symptoms.To date,rare cases of amyloidosis with pulmonary hypertension have been reported.Of note,the optimal treatments for cardiac amyloidosis complicated with pulmonary hypertension remain unclear.CASE SUMMARY We report a case of a 51-year-old woman who presented with progressively worsening dyspnea.Transthoracic echocardiography indicated severe pulmonary hypertension.Twenty-seven months after first admission,the patient returned with symptoms of progressive heart failure.A myocardial tissue sample stained with Congo red was positive,and the patient was ultimately diagnosed with AL amyloidosis with cardiac involvement.CONCLUSION Although pulmonary hypertension may be idiopathic,it is frequently associated with other conditions.In rare cases,pulmonary hypertension can be a complication of AL amyloidosis,which should be seriously considered in any adult presenting with nonspecific signs or symptoms of cardiac distress.

温度和应变速率对Zr_(50)Ti_(50)合金在β单相区热变形行为的影响（英文）

在温度为700~850°C和应变速率为0.001~1s^(-1)的条件下,研究了Zr_(50)Ti_(50)合金在β单相区的热变形行为和组织演变。流变曲线呈现典型的流变软化特征。在较高的应变速率下,出现了不连续屈服现象,这一特点在其他传统锆合金中没有发现。计算得到表观变形激活能为103 kJ/mol,并建立了该合金在β单相区的流变应力与应变速率和变形温度之间的本构方程。分析表明该合金的热变形机制主要为动态回复,并且由于较强的动态回复效果而抑制了动态再结晶。随后,通过计算建立了合金的热加工图,并根据热加工图找到了合金在β单相区的最佳热变形加工参数为温度830~850°C,变形速率为0.56~1s^(-1)。

Outpatient Experience of Human Caring Scale （OEHC-Scale）： Improvement by Delphi Method

Based on the outpatient interview and literature review, the initial framework of the outpatient experience of human caring scale was formed with 9 dimensions of outpatient process. The research aim was to improve the scale by Delphi method. Sixteen experts in medical management, human caring or medical education were invited to evaluate the importance of the dimensions and items of the scale and provided some expertise via filling out the DeLphi consultation questionnaires twice in the consulting round. In the first round, the recovery rate showing the experts＇ positivity was 80%; the coefficient of reliability （Cr） ascertaining the authority of the evaluation was 0.92; the mean and full mark ratios responding the concentration of the evaluation were 2.88-4.94 and 6.25%-93.75% respectively; the coefficients of variation （CV） and the Kendall＇s W determining the concordance of the evaluation were 5.06%-52.15% and 0.21-0.24 respectively. In the second round, the recovery rate was 93.75%; the Cr was 0.93; the mean was 3.93-4.93; the full mark ratios were 26.67%-93.33%; the Kendall＇s W was 0.14- 0.31, the CV was 5.25%-23.61%. Via the two-round Delphi study, the scale that included 10 dimensions and 61 items has been improved. Ten dimensions are pre-hospital medical service, guidance, registration, waiting, diagnosis ＆ treatment, paying, inspection ＆ assay, medicine receiving, therapy/injection/transfusion and global evaluation. It was concluded that Chinese scholars have paid high attention to human caring and outpatient experience. The experts have given high agreements about the dimensions which were established with Chinese outpatient process. The dimensions are different from the similar researches about outpatient experience study. In the future, it is necessary to survey the outpatients to test the construct validity, internal consistency reliability and others of the scale to improve the scale.

氰化给体中分子间相互作用促进的全小分子光伏混合物的超快电子转移

氰基取代被认为是优化全小分子有机太阳能电池性能的可行方法.然而,氰基取代对太阳能电池中电荷产生动力学的影响仍未得到探索.本文光谱研究表明,在全小分子太阳能电池中,氰化给体中增强的分子间电荷转移相互作用会显著促进共混物中的电子转移.实验发现,在氰基取代给体中,分子间相互作用引起的离域激发,在混合物中会进行超快电子转移.相比之下,在没有氰基取代的给体中剩余的局域激发态,并没有积极参与电荷分离.此发现很好地解释了为何氰化取代给体的共混物器件的性能会得到提升,表明可以通过调控分子间相互作用、来优化全小分子器件性能.

Effect of vibration frequency on microstructure and performance of high chromium cast iron prepared by lost foam casting

In the present research, high chromium cast irons(HCCIs) were prepared using the lost foam casting(LFC) process. To improve the wear resistance of the high chromium cast irons(HCCIs), mechanical vibration was employed during the solidification of the HCCIs. The effects of vibration frequency on the microstructure and performance of the HCCIs under as-cast, as-quenched and as-tempered conditions were investigated. The results indicated that the microstructures of the LFC-produced HCCIs were refined due to the introduction of mechanical vibration, and the hardness was improved compared to that of the alloy without vibration. However, only a slight improvement in hardness was found in spite of the increase of vibration frequency. In contrast, the impact toughness of the as-tempered HCCIs increased with an increase in the vibration frequency. In addition, the wear resistance of the HCCIs was improved as a result of the introduction of vibration and increased with an increase in the vibration frequency.

Evaluation of the value of multiparameter combined analysis of serum markers in the early diagnosis of gastric cancer

BACKGROUND In early gastric cancer(GC),tumor markers are increased in the blood.The levels of these markers have been used as important indexes for GC screening,early diagnosis and prognostic evaluation.However,specific tumor markers have not yet been discovered.Diagnosis based on a single tumor marker has limited significance.The detection rate of GC is still very low.AIM To improve the diagnostic value of blood markers for GC.METHODS We used a multiparameter joint analysis of 77 indexes of malignant GC and gastric polyp(GP),64 indexes of GC and healthy controls(Ctrls).RESULTS By analyzing the data,there are 27 indexes in the final Ctrls vs GC with P values<0.01,the area under the curve(AUC)of albumin is the largest in Ctrls vs GC,and the AUC was 0.907.30 indexes in GP vs GC have P values<0.01.Among them,the D-dimer showed an AUC of 0.729.The 27 indexes in Ctrls vs GC and 30 indexes in GP vs GC were used for binary logistic regression,discriminant analysis,classification tree analysis and artificial neural network analysis model.For the ability to distinguish between Ctrls vs GC,GP vs GC,artificial neural networks had better diagnostic value when compared with classification tree,binary logistic regression,and discriminant analysis.When compared Ctrl and GC,the overall prediction accuracy was 92.9%,and the AUC was 0.992(0.980,1.000).When compared GP and GC,the overall prediction accuracy was 77.9%,and the AUC was 0.969(0.948,0.990).CONCLUSION The diagnostic effect of multi-parameter joint artificial neural networks analysis is significantly better than the single-index test diagnosis,and it may provide an assistant method for the detection of GC.

Diagnostic value of four serum exosome microRNAs panel for the detection of colorectal cancer

BACKGROUND Early detection,early diagnosis,and early treatment are currently accepted methods that can effectively improve the efficacy of colorectal cancer(CRC)treatment.Exosomes were demonstrated to be potential tumor molecular markers.AIM To evaluate the diagnostic value of CRC by detecting four exosomal microRNAs(miRNAs)(miR-15b,miR-16,miR-21,and miR-31)that were demonstrated to have potential diagnostic value in serum.METHODS Relative expression levels of miR-15b,miR-16,miR-21,and miR-31 in 123 CRC,117 colorectal adenoma,and 150 healthy controls were detected,and single and panel models were evaluated.The 2-ΔΔCt method was used to calculate the relative expression of miRNA compared to the internal control(U6).Eighty-one CRC patients,67 colorectal adenoma patients,and 90 healthy controls were used for validation.RESULTS Compared to the healthy control group,the best indicator of the four miRNAs was miR-15b,and the sensitivity and specificity were 81.33%and 91.80%,respectively.For miR-15b,miR-21,and miR-31 individually,the sensitivity and specificity were 91.95%and 97.62%,95.06%and 94.44%,respectively.Compared to the colorectal adenoma group,miR-15b,miR-16,and miR-21 in the CRC group showed significant differences(P<0.05).The best single indicator was miR-16,with a sensitivity and specificity of 79.05%and 71.55%.The sensitivity and specificity of a panel that included miR-15b,miR-16,and miR-21 were 81.21%and 81.03%,and 85.19%and 82.09%,respectively,in the validation.CONCLUSION We built and validated a diagnostic model containing miR-15b,miR-21,and miR-31 expression levels to discriminate the healthy control group and CRC group,and its sensitivity and specificity were 95.06%and 94.44%,respectively.The miR-15b,miR-16,and miR-21 panel was used to discriminate the colorectal adenoma group and CRC group with a sensitivity and specificity of 85.19%and 82.09%,respectively.

HNCO在201 nm的离子成像光解动力学:CO(X^1Σ^+)与NH(a^1△)态相关性（英文）

本文通过时间切片离子速度成像技术在201nm附近研究了HNCO分子在S1电子激发态的光解动力学. CO产物通过共振增强多光子电离的方法进行了选态探测,获得了CO产物的振动基态和激发态切片影像.从CO的影像得到了解离产物的能量分布和空间角分布,确定了NH(a^1Δ)产物的振转态分布信息.研究发现1NH的振动分支比(v=1/v=0)随CO(v=0)转动能的增大先增大后下降,展现了1NH与CO之间特殊的态态相关性.大约一半的可资用能分配给解离产物的平动自由度.负的各向异性参数表明HNCO的光解是个快速的直接解离过程.

Effects of fluid recirculation on mass transfer from the arterial surface to flowing blood

The effect of disturbed flow on the mass trans- fer from arterial surface to flowing blood was studied nu- merically, and the results were compared with that of our previous work. The arterial wall was assumed to be vis- coelastic and the blood was assumed to be incompressible and non-Newtonian fluid, which is more close to human arte- rial system. Numerical results indicated that the mass trans- fer from the arterial surface to flowing blood in regions of disturbed flow is positively related with the wall shear rates and it is significantly enhanced in regions of disturbed flow with a local minimum around the reattachment point which is higher than the average value of the downstream. There- fore, it may be implied that the accumulation of cholesterol or lipids within atheromatous plaques is not caused by the reduced efflux of cholesterol or lipids, but by the infiltration of the LDL （low-density lipoprotein） from the flowing blood to the arterial wall.

Ion-Velocity Map Imaging Study of Photodissociation Dynamics of Acetaldehyde

在激进的隧道 CH3+HCO 的乙醛的光致离解动力学是用在 275321 nm 的光分解作用波长范围的 time-sliced 速度地图成像技术的 reinvestigated。CH3 碎片被探查了经由(2+1 ) 提高回声的 multiphoton 电离。图象为在地面和激动的状态形成的 CH3 被测量(v 2=0 并且 1 ) 伞震动的模式。为在从 S1 状态交叉的 intersystem 以后的 T1 状态上的乙醛分离，产品与高翻译的精力版本和低内部刺激被形成。两碎片的旋转、震动的精力与增加光致离解精力增加。三位字节障碍高度在 3.881 点被估计吗？？

Solidification of solvent additive for stable binary polymer solar cells with~19%efficiency

Polymer solar cells(PSCs)have garnered considerable attention due to their numerous benefits,such as solution-processability,and potential applications in flexible and semitransparent devices.With the development of photovoltaic materials and device structures,power conversion efficiencies(PCEs)of PSCs have exceeded 19%to date[1,2].Moreover,an ideal morphology for efficient and stable PSCs is extremely essential[3,4].

Side-chain engineering of high-efficiency conjugated polymer photovoltaic materials

In recent years,conjugated polymers have attracted great attention in the application as photovoltaic donor materials in polymer solar cells(PSCs).Broad absorption,lower-energy bandgap,higher hole mobility,relatively lower HOMO energy levels,and higher solubility are important for the conjugated polymer donor materials to achieve high photovoltaic performance.Side-chain engineering plays a very important role in optimizing the physicochemical properties of the conjugated polymers.In this article,we review recent progress on the side-chain engineering of conjugated polymer donor materials,including the optimization of flexible side-chains for balancing solubility and intermolecular packing(aggregation),electron-withdrawing substituents for lowering HOMO energy levels,and two-dimension(2D)-conjugated polymers with conjugated side-chains for broadening absorption and enhancing hole mobility.After the molecular structural optimization by side-chain engineering,the2D-conjugated polymers based on benzodithiophene units demonstrated the best photovoltaic performance,with powerconversion efficiency higher than 9%.

11.2% Efficiency all-polymer solar cells with high open-circuit voltage

Herein,we fabricated all-polymer solar cells(all-PSCs)based on a fluorinated wide-bandgap p-type conjugated polymer PM6 as the donor,and a narrow bandgap n-type conjugated polymer PZ1 as the acceptor.In addition to the complementary absorption and matching energy levels,the optimized blend films possess high cystallinity,predominantly face-on stacking,and a suitable phase separated morphology.With this active layer,the devices exhibited a high Vocof 0.96 V,a superior Jscof 17.1 mA cm^-2,a fine fill factor(FF)of 68.2%,and thus an excellent power conversion efficiency(PCE)of 11.2%,which is the highest value reported to date for single-junction all-PSCs.Furthermore,the devices showed good storage stability.After 80 d of storage in the N2-filled glovebox,the PCE still remained over 90%of the original value.Large-area devices(1.1 cm^2)also demonstrated an outstanding performance with a PCE of 9.2%,among the highest values for the reported large-area all-PSCs.These results indicate that the PM6:PZ1 blend is a promising candidate for scale-up production of large area high-performance all-PSCs.

Novel DPY19L2 variants in globozoospermic patients and the overcoming this male infertility

Globozoospermia has been reported to be a rare but severe causation of male infertility,which results from the failure of acrosome biogenesis and sperm head shaping.Variants of dpy-19-like 2(DPY19L2)are highly related to globozoospermia,but related investigations have been mainly performed in patients from Western countries.Here,we performed a screening of DPY19L2 variants in a cohort of Chinese globozoospermic patients and found that five of nine patients carried DPY19L2 deletions and the other four patients contained novel DPY19L2 point mutations,as revealed by whole-exome sequencing.Patient 3(P3)contained a heterozygous variant(c.2126+5G>A),P6 contained a homozygous nonsense mutation(c.1720C>T,p.Arg574*),P8 contained compound heterozygous variants(c.H82-1184delATCf p.Leu394_Ser395deIinsPhe;c.368A>T,p.Hisl23Arg),and P9 contained a heterozygous variant(c.H82-1184delATCTTI frameshift).We also reported intracytoplasmic sperm injection(ICSI)outcomes in the related patients,finding that ICSI followed by assisted oocyte activation(AOA)with calcium ionophore achieved high rates of live births.In summary,the infertility of these patients results from DPY19L2 dysfunction and can be treated by ICSI together with AOA.

Benzotriazole Based 2D-conjugated Polymer Donors for High Performance Polymer Solar Cells

To design high efficiency polymer solar cells(PSCs), it is of great importance to develop suitable polymer donors that work well with the low bandgap acceptors, providing complementary absorption, forming interpenetrating networks in the active layers and minimizing energy loss. Recently, we developed a series of two-dimension-conjugated polymers based on bithienylbenzodithiophene-alt-benzotriazole backbone bearing different conjugated side chains, generally called J-series polymers. They are medium energy bandgap(Eg) polymers(Eg of ca. 1.80 eV)with strong absorptions in the range of 400-650 nm, and exhibit ordered crystalline structures, high hole mobilities, and more interestingly,tunable energy levels depending on the structure variations. In this feature article, we highlight our recent efforts on the design and synthesis of those J-series polymer donors, including an introduction on the polymer design strategy and emphasis on the crucial function of differential conjugated side chain. Finally, the future opportunities and challenges of the J-series polymers in PSCs are discussed.

Recent progress in organic solar cells(PartⅠmaterial science)

During past several years,the photovoltaic performances of organic solar cells(OSCs)have achieved rapid progress with power conversion efficiencies(PCEs)over 18%,demonstrating a great practical application prospect.The development of material science including conjugated polymer donors,oligomer-like organic molecule donors,fused and nonfused ring acceptors,polymer acceptors,single-component organic solar cells and water/alcohol soluble interface materials are the key research topics in OSC field.Herein,the recent progress of these aspects is systematically summarized.Meanwhile,the current problems and future development are also discussed.

Recent progress in organic solar cells(PartⅡdevice engineering)

1 Introduction Organic solar cells(OSCs)belong to a multidisciplinary field composed of chemistry,materials science,physics,engineering,etc.For a better reviewing of this field,we briefly divide the research field of OSCs into two parts:material science and device engineering.In our previous review,the material science part of OSCs,including conjugated polymer donors and acceptors,small molecular donors and acceptors.