Exosomes and long non-coding RNAs(lncRNAs)are emerging as important elements contributing to a more comprehensive understanding of cancer development and progression.The discovery of lncRNAs in exosomes further indica...Exosomes and long non-coding RNAs(lncRNAs)are emerging as important elements contributing to a more comprehensive understanding of cancer development and progression.The discovery of lncRNAs in exosomes further indicates their bona fide biological functional roles in cancer development and drug resistance.In this review,we describe the biogenesis of exosomes and summarize the function of exosomal lncRNAs in the field of cancer research.These findings strikingly advance current knowledge of exosomal lncRNAs and suggest that they may be promising diagnostic biomarkers and therapeutic targets for cancer.展开更多
基金supported by the National Natural Science Foundation of China(Nos.81672791 and 81872300)the Foundation of the Department of Education of Zhejiang Province,China(No.Y201224954)+1 种基金the Zhejiang Provincial Natural Science Foundation of China(No.LY14H040007)the Zhejiang Provincial Natural Science Fund for Distinguished Young Scholars of China(No.LR18C060002)
文摘Exosomes and long non-coding RNAs(lncRNAs)are emerging as important elements contributing to a more comprehensive understanding of cancer development and progression.The discovery of lncRNAs in exosomes further indicates their bona fide biological functional roles in cancer development and drug resistance.In this review,we describe the biogenesis of exosomes and summarize the function of exosomal lncRNAs in the field of cancer research.These findings strikingly advance current knowledge of exosomal lncRNAs and suggest that they may be promising diagnostic biomarkers and therapeutic targets for cancer.
