Objective To explore the value of magnetic resonance diffusion kurtosis imaging in diagnosing early tiny changes of brain tissue after mild traumatic brain injury.Methods A total of 22 patients with mild traumatic bra...Objective To explore the value of magnetic resonance diffusion kurtosis imaging in diagnosing early tiny changes of brain tissue after mild traumatic brain injury.Methods A total of 22 patients with mild traumatic brain injury(study group)and 20 healthy subjects(control group)were enrolled in this study,and diffusion kurtosis imaging magnetic resonance scanning was employed in all subjects.fractional anisotropy,fractional anisotropy of kurtosis,mean kurtosis,axial kurtosis and radial kurtosis of diffusion kurtosis imaging parameters in the genu of corpus callosum,splenium corporis callosi,internal capsule,thalamus,putamen,cortex of frontal lobe,temporal lobe and parietal lobe at control group,the injured side and the mirror regions were measured,and the results were compared between the two groups.The receiver operating characteristic curve was used to evaluate the ability of different parameters in diagnosing mild traumatic brain injury.Results Compared with the control group,in the study group fractional anisotropy values of bilateral genu of corpus callosum,splenium corporis callosi,internal capsule and thalamus were significantly reduced,and fractional anisotropy of kurtosis values of bilateral thalamus and putamen were significantly reduced,and the differences were statistically significant(P<0.05).Compared with the control group,in the study group mean kurtosis and axial kurtosis values of bilateral genu of corpus callosum,posterior limb of Internal capsule,thalamus,putamen and cortex of temporal lobe were significantly reduced,while radial kurtosis values in the genu of corpus callosum,thalamus,cortex of frontal lobe,temporal lobe at the injured side were increased,and the differences were statistically significant(P<0.05).Conclusion DKI techniques can sensitively detect the early tiny pathologic changes of cerebral tissue in mild traumatic brain injury patients,which provide more imaging evidence for the clinical early diagnosis treatment and prognosis.展开更多
Cobalt-based phosphides show excellent hydrogen evolution reaction(HER)performance,however,improving the intrinsic activity and stability of it in alkaline electrolyte still remains a challenge.Herein,CoRuOH/Co_(2)P/C...Cobalt-based phosphides show excellent hydrogen evolution reaction(HER)performance,however,improving the intrinsic activity and stability of it in alkaline electrolyte still remains a challenge.Herein,CoRuOH/Co_(2)P/CF with heterojunction structure was developed by means of molten salt and rapid hydrolysis(30 s).The OH-from rapid surface hydrolysis of Co_(2)P as a hydrogen adsorption site can facilitate the formation of thin CoRuOH layer as a water dissociation site,which may bring out better synergistic effect for alkaline HER.Moreover,the covering of CoRuOH can improve the stability of Co_(2)P for HER.When drives at 100 mA/cm^(2),it only requires overpotential of 81 mV in 1.0 mol/L KOH(25℃).Even at higher current density(1000 mA/cm^(2)),CoRuOH/Co_(2)P/CF can also operate stability for at least 100 h.When coupling with NiFe-LDH/IF in a two-electrode system,the voltage of NiFe-LDH/IF(+)||CoRuOH/Co_(2)P/CF(-)at 1000 mA/cm^(2)is merely 1.77 V with 100 h,demonstrating great potential for water splitting.The implementation of this work provides a new strategy and reference for the further improvement of transition metal phosphides as HER electrocatalysts.展开更多
Fe-nitrogen-carbon(Fe-N-C)-and Co-nitrogen-carbon(Co-N-C)-based electrocatalysts have been widely concerned because of their high OER/ORR activity,low metal cost,and simple preparation.The exploration of Fe-N-C and Co...Fe-nitrogen-carbon(Fe-N-C)-and Co-nitrogen-carbon(Co-N-C)-based electrocatalysts have been widely concerned because of their high OER/ORR activity,low metal cost,and simple preparation.The exploration of Fe-N-C and Co-N-C single atombased catalysts with high activity and stability to overcome the slow kinetics of oxygen reduction and oxygen evolution reactions is also the key to the development of efficient electrolytic water,fuel cells,and rechargeable metal-air batteries.Fe-N-C and Co-N-C single atom-based electrocatalysts have the advantages of a high utilization rate of metal atoms and high electrocatalytic activity,and are ideal catalysts for promoting electrochemical energy conversion and storage.The general principles of designing Fe-N-C and Co-N-C single atom-based electrocatalysts are reviewed in this paper.Then,the strategies to improve the bifunctional catalytic activity and stability are proposed.Finally,the challenges and prospects of Fe-N-C and Co-N-C single atom-based catalysts are well summarized.This review will provide a reference for the directed optimization of Fe-N-C and Co-N-C single atom-based catalysts.展开更多
In order to increase the processability and process window of the selective laser melting(SLM)-fabricated Al−Mn−Mg−Er−Zr alloy,a novel Si-modified Al−Mn−Mg−Er−Zr alloy was designed.The effect of Si alloying on the sur...In order to increase the processability and process window of the selective laser melting(SLM)-fabricated Al−Mn−Mg−Er−Zr alloy,a novel Si-modified Al−Mn−Mg−Er−Zr alloy was designed.The effect of Si alloying on the surface quality,processability,microstructure,and mechanical properties of the SLM-fabricated alloy was studied.The results showed that introducing Si into the Al−Mn−Mg−Er−Zr alloy prevented balling and keyhole formation,refined the grain size,and reduced the solidification temperature,which eliminated cracks and increased the processability and process window of the alloy.The maximum relative density of the SLM-fabricated Si/Al−Mn−Mg−Er−Zr alloy reached 99.6%.The yield strength and ultimate tensile strength of the alloy were(371±7)MPa and(518±6)MPa,respectively.These values were higher than those of the SLM-fabricated Al−Mn−Mg−Er−Zr and other Sc-free Al−Mg-based alloys.展开更多
Background:China is the second highest pulmonary tuberculosis(PTB)burden country worldwide.However,retreatment of PTB has often developed resistance to at least one of the four first-line anti-TB drugs.The cure rate(a...Background:China is the second highest pulmonary tuberculosis(PTB)burden country worldwide.However,retreatment of PTB has often developed resistance to at least one of the four first-line anti-TB drugs.The cure rate(approximately 50.0–73.3%)and management of retreatment of PTB in China needs to be improved.Qinbudan decoction has been widely used to treat PTB in China since the 1960s.Previously clinical studies have shown that the Qinbudan tablet(QBDT)promoted sputum-culture negative conversion and lesion absorption.However,powerful evidence from a randomized controlled clinical trial is lacking.Therefore,the aim of this study was to compare the efficacy and safety of QBDT as an adjunct therapy for retreatment of PTB.Methods:We conducted a multicenter,randomized,double-blind,placebo-controlled clinical trial in China.People diagnosed with PTB were enrolled who received previous anti-TB treatment from April 2011 to March 2013.The treatment group received an anti-TB regimen and QBDT,and the control group was administered an anti-TB regimen plus placebo.Anti-TB treatment options included isoniazid,rifampicin,pyrazinamide,ethambutol,streptomycin for 2 months(2HRZES),followed by isoniazid,rifampicin,ethambutol for 6 months(6HRE),daily for 8 months.Primary outcome was sputum-culture conversion using the MGIT 960 liquid medium method.Secondary outcomes included lung lesion absorption and cavity closure.Adverse events and reactions were observed after treatment.A structured questionnaire was used to record demographic information and clinical symptoms of all subjects.Data analysis was performed by SPSS 25.0 software in the full analysis set(FAS)population.Results:One hundred eighty-one cases of retreatment PTB were randomly divided into two groups:the placebo group(88 cases)and the QBDT group(93 cases).A total of 166 patients completed the trial and 15 patients lost to follow-up.The culture conversion rate of the QBDT group and placebo group did not show a noticeable improvement by using the covariate sites to correct the rate differences(79.6%vs 69.3%;rate difference=0.10,95%confidence interval(CI):-0.02–0.23;F=2.48,P=0.12)after treatment.A significant 16.6%increase in lesion absorption was observed in the QBDT group when compared with the placebo group(67.7%vs 51.1%;rate difference=0.17,95%CI:0.02–0.31;χ2=5.56,P=0.02).The intervention and placebo group did not differ in terms of cavity closure(25.5%vs 21.1%;rate difference=0.04,95%CI:-0.21–0.12;χ2=0.27,P=0.60).Two patients who received chemotherapy and combined QBDT reported pruritus/nausea and vomiting.Conclusions:No significant improvement in culture conversion was observed for retreatment PTB with traditional Chinese medicine plus standard anti-TB regimen.However,QBDT as an adjunct therapy significantly promoted lesion absorption,thereby reducing lung injury due to Mycobacterium tuberculosis infection.Trial registration:This trial is registered at ClinicalTrials.gov,NCT02313610.展开更多
Portulaca oleracea, a plant species used as medicine and food, is widely spread in most areas of China. It is also a popular food in some Europe and Mediterranean countries. Purslane contains a variety of chemical con...Portulaca oleracea, a plant species used as medicine and food, is widely spread in most areas of China. It is also a popular food in some Europe and Mediterranean countries. Purslane contains a variety of chemical constituents with pharmacological activities, such as antitumor, hypoglycemic, antioxidant, antibacterial,anti-inflammatory activities. It is also full of plenty of nutrients serving as a diet food or healthy food.Here we reviewed purslane in the following aspects: botanical resources, ethnopharmacological function,chemical constituents, pharmacology and pharmacokinetics, safety evaluation and toxicity, and clinical applications.展开更多
A 2.5-mm Fe72.5B15.6Si7.8Nb1.7Zr1.7Cu0.7 glassy rod was successfully fabricated using copper mold casting.The introduction of Cu resulted in the formation of large quantities of a-Fe nanoparticles embedded in the glas...A 2.5-mm Fe72.5B15.6Si7.8Nb1.7Zr1.7Cu0.7 glassy rod was successfully fabricated using copper mold casting.The introduction of Cu resulted in the formation of large quantities of a-Fe nanoparticles embedded in the glassy matrix after isothermal annealing.The Fe72.5B15.6Si7.8Nb1.7Zr1.7Cu0.7 nanocrystalline alloy exhibited high saturation magnetization(~1.26 T) and a low coercive force(~0.8 A/m) after annealing at 833 K for 15 min due to the precipitation of ~15-nm-sized a-Fe nanoparticles in the glassy matrix.The structural evolution of the FeBSiNbZrCu amorphous alloy during the annealing process was discussed using a dual-cluster model.展开更多
Three-arm and four-arm star-like polybutadienes (PBds) were synthesized via the combination of living anionic polymerization and the click coupling method. Kinetic study showed that the click reaction between the az...Three-arm and four-arm star-like polybutadienes (PBds) were synthesized via the combination of living anionic polymerization and the click coupling method. Kinetic study showed that the click reaction between the azido group terminated PBd-t-N3 and the alkyne-containing multifunctional linking reagent was fast and highly efficient. All coupling reactions were fully accomplished within 40 min at 50 ℃ in toluene in the presence of the reducing agent Cu(0), proven by 1H-NMR, FTIR and GPC measurements. For the coupling reactions between the PBd-t-N3 polymer and dialkyne-containing compound, the final conversion of the coupled PBd-PBd polymer was ca. 97.0%. When a PBd-t-N3 polymer was reacted with trialkyne-containing or tetraalkyne-containing compound, the conversion of three-arm or four-arm PBd was around 95.5% or 87.0%, respectively. Several factors influencing the coupling efficiency were studied, including the molecular weight of the initial PBd-t-N3, arm numbers and the molar ratio of the azido group to the alkynyl group. The results indicated that the conversion of the target products would be promoted when the molecular weight of the PBd-t-N3 was low and the molar ratio of the azido to alkynyl groups was close to 1.展开更多
Effects of branches on the crystallization kinetics of polypropylene-g-polystyrene (PP-g-PS) and polypropylene-g- poly(n-butyl acrylate) (PP-g-PnBA) graft copolymers with well-defined molecular structures were s...Effects of branches on the crystallization kinetics of polypropylene-g-polystyrene (PP-g-PS) and polypropylene-g- poly(n-butyl acrylate) (PP-g-PnBA) graft copolymers with well-defined molecular structures were systematically investigated by DSC. The Avrami equation was used to analyze the isothermal crystallization process, while the analysis of nonisothermal crystallization process was based on the Jeziorny-modified Avrami model and Mo model. The kinetics results of isothermal and nonisothermal crystallization verified the peculiar effects of branches on the crystallization process of PP backbones in PP-g-PS and PP-g-PnBA graft copolymers: on one hand, the interaction between branches (n-n interaction between PS branches, or dipole-dipole interaction between PnBA branches) restrained the mobility and reptation ability of the PP backbones, which hindered the crystallization process; on the other hand, the heterogeneous nucleation effect resulting from the branched structure and fluctuation-assisted nucleation mechanism (caused by microphase separation between the PS or PnBA rich phase and the PP rich phase) became more pronounced with increasing branch length, which facilitated the crystallization process.展开更多
The ionic conductivity and the mechanical strength are two key factors for the performance of poly(ethylene oxide)(PEO) based polyelectrolytes. However, crystallized PEO suppresses ion conductivity at low temperat...The ionic conductivity and the mechanical strength are two key factors for the performance of poly(ethylene oxide)(PEO) based polyelectrolytes. However, crystallized PEO suppresses ion conductivity at low temperature and melted PEO has low mechanical strength at high temperature. Here, random binary brush copolymer composed of PEO-and polystyrene(PS)-based side chains is synthesized. PEO crystallinity is suppressed by the introduction of PS brushes. Doping with lithium trifluoromethanesulfonate(Li Tf) induces microphase separation. Due to a random arrangement of the brushes, the microphase segregation is incomplete even at high salt loading, which provides both high ionic conductivity and high mechanical strength at room temperature. These results provide opportunities for the design of polymeric electrolytes to be used at room temperature.展开更多
基金This work was supported by the Zhangjiakou Key Research and Development Program(1921136H).
文摘Objective To explore the value of magnetic resonance diffusion kurtosis imaging in diagnosing early tiny changes of brain tissue after mild traumatic brain injury.Methods A total of 22 patients with mild traumatic brain injury(study group)and 20 healthy subjects(control group)were enrolled in this study,and diffusion kurtosis imaging magnetic resonance scanning was employed in all subjects.fractional anisotropy,fractional anisotropy of kurtosis,mean kurtosis,axial kurtosis and radial kurtosis of diffusion kurtosis imaging parameters in the genu of corpus callosum,splenium corporis callosi,internal capsule,thalamus,putamen,cortex of frontal lobe,temporal lobe and parietal lobe at control group,the injured side and the mirror regions were measured,and the results were compared between the two groups.The receiver operating characteristic curve was used to evaluate the ability of different parameters in diagnosing mild traumatic brain injury.Results Compared with the control group,in the study group fractional anisotropy values of bilateral genu of corpus callosum,splenium corporis callosi,internal capsule and thalamus were significantly reduced,and fractional anisotropy of kurtosis values of bilateral thalamus and putamen were significantly reduced,and the differences were statistically significant(P<0.05).Compared with the control group,in the study group mean kurtosis and axial kurtosis values of bilateral genu of corpus callosum,posterior limb of Internal capsule,thalamus,putamen and cortex of temporal lobe were significantly reduced,while radial kurtosis values in the genu of corpus callosum,thalamus,cortex of frontal lobe,temporal lobe at the injured side were increased,and the differences were statistically significant(P<0.05).Conclusion DKI techniques can sensitively detect the early tiny pathologic changes of cerebral tissue in mild traumatic brain injury patients,which provide more imaging evidence for the clinical early diagnosis treatment and prognosis.
基金financially supported by the National Natural Science Foundation of China(Nos.52174283 and 52274308)。
文摘Cobalt-based phosphides show excellent hydrogen evolution reaction(HER)performance,however,improving the intrinsic activity and stability of it in alkaline electrolyte still remains a challenge.Herein,CoRuOH/Co_(2)P/CF with heterojunction structure was developed by means of molten salt and rapid hydrolysis(30 s).The OH-from rapid surface hydrolysis of Co_(2)P as a hydrogen adsorption site can facilitate the formation of thin CoRuOH layer as a water dissociation site,which may bring out better synergistic effect for alkaline HER.Moreover,the covering of CoRuOH can improve the stability of Co_(2)P for HER.When drives at 100 mA/cm^(2),it only requires overpotential of 81 mV in 1.0 mol/L KOH(25℃).Even at higher current density(1000 mA/cm^(2)),CoRuOH/Co_(2)P/CF can also operate stability for at least 100 h.When coupling with NiFe-LDH/IF in a two-electrode system,the voltage of NiFe-LDH/IF(+)||CoRuOH/Co_(2)P/CF(-)at 1000 mA/cm^(2)is merely 1.77 V with 100 h,demonstrating great potential for water splitting.The implementation of this work provides a new strategy and reference for the further improvement of transition metal phosphides as HER electrocatalysts.
基金supported by NSFC(52373215)Sichuan Science and Technology Program(2023NSFSC0086)Fundamental Research Funds for the Central Universities(YJ2021156)。
文摘Fe-nitrogen-carbon(Fe-N-C)-and Co-nitrogen-carbon(Co-N-C)-based electrocatalysts have been widely concerned because of their high OER/ORR activity,low metal cost,and simple preparation.The exploration of Fe-N-C and Co-N-C single atombased catalysts with high activity and stability to overcome the slow kinetics of oxygen reduction and oxygen evolution reactions is also the key to the development of efficient electrolytic water,fuel cells,and rechargeable metal-air batteries.Fe-N-C and Co-N-C single atom-based electrocatalysts have the advantages of a high utilization rate of metal atoms and high electrocatalytic activity,and are ideal catalysts for promoting electrochemical energy conversion and storage.The general principles of designing Fe-N-C and Co-N-C single atom-based electrocatalysts are reviewed in this paper.Then,the strategies to improve the bifunctional catalytic activity and stability are proposed.Finally,the challenges and prospects of Fe-N-C and Co-N-C single atom-based catalysts are well summarized.This review will provide a reference for the directed optimization of Fe-N-C and Co-N-C single atom-based catalysts.
基金supported by the Natural Science Foundation of Sichuan Province(2023NSFSC0086)the Fundamental Research Funds for the Central Universities(YJ2021156).
基金the National Natural Science Foundation of China(Nos.51801079,52001140)the Portugal National Funds through FCT Project(No.2021.04115).
文摘In order to increase the processability and process window of the selective laser melting(SLM)-fabricated Al−Mn−Mg−Er−Zr alloy,a novel Si-modified Al−Mn−Mg−Er−Zr alloy was designed.The effect of Si alloying on the surface quality,processability,microstructure,and mechanical properties of the SLM-fabricated alloy was studied.The results showed that introducing Si into the Al−Mn−Mg−Er−Zr alloy prevented balling and keyhole formation,refined the grain size,and reduced the solidification temperature,which eliminated cracks and increased the processability and process window of the alloy.The maximum relative density of the SLM-fabricated Si/Al−Mn−Mg−Er−Zr alloy reached 99.6%.The yield strength and ultimate tensile strength of the alloy were(371±7)MPa and(518±6)MPa,respectively.These values were higher than those of the SLM-fabricated Al−Mn−Mg−Er−Zr and other Sc-free Al−Mg-based alloys.
基金Project supported by the National Key Research and Development Program of China(No.2017YFC1200203)the Open Fund of Shanghai Key Laboratory of Meteorology and Health(No.QXJK201605)+1 种基金the National Natural Science Foundation of China(No.71363001)the Fourth Round of Three-Year Public Health Action Plan of Shanghai(Nos.15GWZK0101 and 15GWZK0202),China
基金This study was supported by the Eleventh Five-Year Support Project of the Ministry of Science and Technology from Ministry of Public Health of China(2010ZX09101-107)。
文摘Background:China is the second highest pulmonary tuberculosis(PTB)burden country worldwide.However,retreatment of PTB has often developed resistance to at least one of the four first-line anti-TB drugs.The cure rate(approximately 50.0–73.3%)and management of retreatment of PTB in China needs to be improved.Qinbudan decoction has been widely used to treat PTB in China since the 1960s.Previously clinical studies have shown that the Qinbudan tablet(QBDT)promoted sputum-culture negative conversion and lesion absorption.However,powerful evidence from a randomized controlled clinical trial is lacking.Therefore,the aim of this study was to compare the efficacy and safety of QBDT as an adjunct therapy for retreatment of PTB.Methods:We conducted a multicenter,randomized,double-blind,placebo-controlled clinical trial in China.People diagnosed with PTB were enrolled who received previous anti-TB treatment from April 2011 to March 2013.The treatment group received an anti-TB regimen and QBDT,and the control group was administered an anti-TB regimen plus placebo.Anti-TB treatment options included isoniazid,rifampicin,pyrazinamide,ethambutol,streptomycin for 2 months(2HRZES),followed by isoniazid,rifampicin,ethambutol for 6 months(6HRE),daily for 8 months.Primary outcome was sputum-culture conversion using the MGIT 960 liquid medium method.Secondary outcomes included lung lesion absorption and cavity closure.Adverse events and reactions were observed after treatment.A structured questionnaire was used to record demographic information and clinical symptoms of all subjects.Data analysis was performed by SPSS 25.0 software in the full analysis set(FAS)population.Results:One hundred eighty-one cases of retreatment PTB were randomly divided into two groups:the placebo group(88 cases)and the QBDT group(93 cases).A total of 166 patients completed the trial and 15 patients lost to follow-up.The culture conversion rate of the QBDT group and placebo group did not show a noticeable improvement by using the covariate sites to correct the rate differences(79.6%vs 69.3%;rate difference=0.10,95%confidence interval(CI):-0.02–0.23;F=2.48,P=0.12)after treatment.A significant 16.6%increase in lesion absorption was observed in the QBDT group when compared with the placebo group(67.7%vs 51.1%;rate difference=0.17,95%CI:0.02–0.31;χ2=5.56,P=0.02).The intervention and placebo group did not differ in terms of cavity closure(25.5%vs 21.1%;rate difference=0.04,95%CI:-0.21–0.12;χ2=0.27,P=0.60).Two patients who received chemotherapy and combined QBDT reported pruritus/nausea and vomiting.Conclusions:No significant improvement in culture conversion was observed for retreatment PTB with traditional Chinese medicine plus standard anti-TB regimen.However,QBDT as an adjunct therapy significantly promoted lesion absorption,thereby reducing lung injury due to Mycobacterium tuberculosis infection.Trial registration:This trial is registered at ClinicalTrials.gov,NCT02313610.
基金supported by National Standardization Project of Traditional Chinese Medicine (No. ZYBZH-C-JL-25)
文摘Portulaca oleracea, a plant species used as medicine and food, is widely spread in most areas of China. It is also a popular food in some Europe and Mediterranean countries. Purslane contains a variety of chemical constituents with pharmacological activities, such as antitumor, hypoglycemic, antioxidant, antibacterial,anti-inflammatory activities. It is also full of plenty of nutrients serving as a diet food or healthy food.Here we reviewed purslane in the following aspects: botanical resources, ethnopharmacological function,chemical constituents, pharmacology and pharmacokinetics, safety evaluation and toxicity, and clinical applications.
基金financially supported by the National Key R&D Program of China(No.2016YFB1100103)the National Natural Science Foundation of China(No.51801079)+1 种基金the Natural Science Foundation for Young Scientists of Jiangsu,China(Nos.BK20180985 and BK20180987)the Natural Science Foundation in Higher Education of Jiangsu,China(No.18KJB430011).
文摘A 2.5-mm Fe72.5B15.6Si7.8Nb1.7Zr1.7Cu0.7 glassy rod was successfully fabricated using copper mold casting.The introduction of Cu resulted in the formation of large quantities of a-Fe nanoparticles embedded in the glassy matrix after isothermal annealing.The Fe72.5B15.6Si7.8Nb1.7Zr1.7Cu0.7 nanocrystalline alloy exhibited high saturation magnetization(~1.26 T) and a low coercive force(~0.8 A/m) after annealing at 833 K for 15 min due to the precipitation of ~15-nm-sized a-Fe nanoparticles in the glassy matrix.The structural evolution of the FeBSiNbZrCu amorphous alloy during the annealing process was discussed using a dual-cluster model.
基金financially supported by the National Natural Science Foundation of China(Nos.51233005,21004060 and 51073149)
文摘Three-arm and four-arm star-like polybutadienes (PBds) were synthesized via the combination of living anionic polymerization and the click coupling method. Kinetic study showed that the click reaction between the azido group terminated PBd-t-N3 and the alkyne-containing multifunctional linking reagent was fast and highly efficient. All coupling reactions were fully accomplished within 40 min at 50 ℃ in toluene in the presence of the reducing agent Cu(0), proven by 1H-NMR, FTIR and GPC measurements. For the coupling reactions between the PBd-t-N3 polymer and dialkyne-containing compound, the final conversion of the coupled PBd-PBd polymer was ca. 97.0%. When a PBd-t-N3 polymer was reacted with trialkyne-containing or tetraalkyne-containing compound, the conversion of three-arm or four-arm PBd was around 95.5% or 87.0%, respectively. Several factors influencing the coupling efficiency were studied, including the molecular weight of the initial PBd-t-N3, arm numbers and the molar ratio of the azido group to the alkynyl group. The results indicated that the conversion of the target products would be promoted when the molecular weight of the PBd-t-N3 was low and the molar ratio of the azido to alkynyl groups was close to 1.
基金financially supported by the National Natural Science Foundation of China for the projects(Nos.51233005 and 51073149)
文摘Effects of branches on the crystallization kinetics of polypropylene-g-polystyrene (PP-g-PS) and polypropylene-g- poly(n-butyl acrylate) (PP-g-PnBA) graft copolymers with well-defined molecular structures were systematically investigated by DSC. The Avrami equation was used to analyze the isothermal crystallization process, while the analysis of nonisothermal crystallization process was based on the Jeziorny-modified Avrami model and Mo model. The kinetics results of isothermal and nonisothermal crystallization verified the peculiar effects of branches on the crystallization process of PP backbones in PP-g-PS and PP-g-PnBA graft copolymers: on one hand, the interaction between branches (n-n interaction between PS branches, or dipole-dipole interaction between PnBA branches) restrained the mobility and reptation ability of the PP backbones, which hindered the crystallization process; on the other hand, the heterogeneous nucleation effect resulting from the branched structure and fluctuation-assisted nucleation mechanism (caused by microphase separation between the PS or PnBA rich phase and the PP rich phase) became more pronounced with increasing branch length, which facilitated the crystallization process.
基金financial support from the National Key Research and Development Program of China(2017YFA0206904,2017YFA0206900)start-up fund of Changchun Institute of Applied Chemistry,Chinese Academy of Sciences
文摘The ionic conductivity and the mechanical strength are two key factors for the performance of poly(ethylene oxide)(PEO) based polyelectrolytes. However, crystallized PEO suppresses ion conductivity at low temperature and melted PEO has low mechanical strength at high temperature. Here, random binary brush copolymer composed of PEO-and polystyrene(PS)-based side chains is synthesized. PEO crystallinity is suppressed by the introduction of PS brushes. Doping with lithium trifluoromethanesulfonate(Li Tf) induces microphase separation. Due to a random arrangement of the brushes, the microphase segregation is incomplete even at high salt loading, which provides both high ionic conductivity and high mechanical strength at room temperature. These results provide opportunities for the design of polymeric electrolytes to be used at room temperature.