期刊文献+
共找到2篇文章
< 1 >
每页显示 20 50 100
Thrombophilia Caused by Beta2-Glycoprotein I Deficiency: In Vitro Study of a Rare Mutation in APOH Gene 被引量:5
1
作者 Xiao-ping ZHANG Wei ZENG +7 位作者 Hui LIU Liang TANG Qing-yun WANG zhi-peng cheng Ying-ying WU Bei HU Wei SHI Yu HU 《Current Medical Science》 SCIE CAS 2018年第2期379-385,共7页
This study aimed to explore the mechanism of a novel mutation (p.Lys38Glu) in apolipoprotein H (APOH) gene causing hereditary beta2-glycoprotein I (β2GPI) deficiency and thrombosis in a proband with thrombophil... This study aimed to explore the mechanism of a novel mutation (p.Lys38Glu) in apolipoprotein H (APOH) gene causing hereditary beta2-glycoprotein I (β2GPI) deficiency and thrombosis in a proband with thrombophilia. The plasma level of β2GPI was measured by ELISA and Western blotting, and anti-β2GPI antibody by ELISA. Lupus anticoagulant (LA) was assayed using the dilute Russell viper venom time. Deficiency of the major natural anticoagulants including protein C (PC), protein S (PS), antithrombin (AT) and thrombomodulin (TM) was excluded from the proband. A mutation analysis was performed by amplification and sequencing of the APOH gene. Wild type and mutant (c.112A〉G) APOH expression plasmids were constructed and transfected into HEK293T cells. The results showed that the thrornbin generation capacity of the proband was higher than that of the other family members. Missense mutation p.Lys38Glu in APOH gene and LA coexisted in the proband. The mutation led to β2GPI deficiency and thrombosis by impairing the protein production and inhibiting the platelet aggregation. It was concluded that the recurrent thrombosis of the proband is associated with the coexistence ofp.Lys38Glu mutation in APOH gene and LA in plasma. 展开更多
关键词 beta2-glycoprotein I lupus anticoagulant MUTATION apolipoprotein H THROMBOPHILIA
下载PDF
Controlled synthesis of silver nanoplates and nanoparticles by reducing silver nitrate with hydroxylamine hydrochloride 被引量:1
2
作者 zhi-peng cheng Xiao-Zhong Chu +3 位作者 Xiao-Qing Wu Ji-Ming Xu Hui Zhong Jing-Zhou Yin 《Rare Metals》 SCIE EI CAS CSCD 2017年第10期799-805,共7页
An easy and effective method of silver nanoplate synthesis technique was created by reducing silver nitrate (AgNO3) with hydroxylamine hydrochloride (NH2OH·HCl) at room temperature. Silver nanoplates of vario... An easy and effective method of silver nanoplate synthesis technique was created by reducing silver nitrate (AgNO3) with hydroxylamine hydrochloride (NH2OH·HCl) at room temperature. Silver nanoplates of various shapes, including triangular, truncated triangular, hexagonal, and truncated hexagonal, exhibit an average width and thickness of approximately 1 μm and 50 nm, respectively. Silver nanoparticles were acquired by placing polyvinyl pyrrolidone (PVP) in the reaction solution. The produced silver nanoparticles are quasi-spherical in shape and - 100 nm in size. The catalytic activity in the thermal decomposition of ammonium perchlorate (AID) was distinguished by thermogravimetric (TG) analysis and differential scanning calorimetry (DSC). The outcomes reveal that the addition of silver nanoplates and nanoparticles diminishes the low decomposition temperature of AP by 7 and 14 ℃ and leads to a drop in the high decomposition temperature of AP by 60 and 110 ℃ and a rise in the total DSC heat release by 0.86 and 1.05 kJ.g^-1, respectively. 展开更多
关键词 Silver nanoparticle Silver nanoplates Formation mechanism Ammonium perchlorate
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部