Bile acids(BAs)are originally known as detergents essential for the digestion and absorption of lipids.In recent years,extensive research has unveiled new functions of BAs as gut hormones that modulate physiological a...Bile acids(BAs)are originally known as detergents essential for the digestion and absorption of lipids.In recent years,extensive research has unveiled new functions of BAs as gut hormones that modulate physiological and pathological processes,including glucose and lipid metabolism,energy expenditure,inflammation,tumorigenesis,cardiovascular disease,and even the central nervous system in addition to cholesterol homeostasis,enterohepatic protection and liver regeneration.BAs are closely linked with gut microbiota which might explain some of their crucial roles in organs.The signaling actions of BAs can also be mediated through specific nuclear receptors and membranebound G protein-coupled receptors.Several pharmacological agents or bariatric surgeries have demonstrated efficacious therapeutic effects on metabolic diseases through targeting BA signaling.In this mini-review,we summarize recent advances in bile-ology,focusing on its translational studies.展开更多
基金Project supported by the National Cancer Institute(No.2R01CA139158)John Hench Foundation to Wen-dong HUANGthe National Natural Science Foundation of China(Nos.81471084 and 81773793)to Li-hua JIN
文摘Bile acids(BAs)are originally known as detergents essential for the digestion and absorption of lipids.In recent years,extensive research has unveiled new functions of BAs as gut hormones that modulate physiological and pathological processes,including glucose and lipid metabolism,energy expenditure,inflammation,tumorigenesis,cardiovascular disease,and even the central nervous system in addition to cholesterol homeostasis,enterohepatic protection and liver regeneration.BAs are closely linked with gut microbiota which might explain some of their crucial roles in organs.The signaling actions of BAs can also be mediated through specific nuclear receptors and membranebound G protein-coupled receptors.Several pharmacological agents or bariatric surgeries have demonstrated efficacious therapeutic effects on metabolic diseases through targeting BA signaling.In this mini-review,we summarize recent advances in bile-ology,focusing on its translational studies.
