Effect of rare earth on morphology and dispersion of TiB2 phase in Al-Ti-B alloy refiner

To investigate the effect of rare earth on size and distribution of TiB2 phase in aluminum alloy refiner,Al-5Ti-1B-RE master alloy was fabricated,and its microstructure and phase constitutions were investigated by the combination of first principles calculations and experimental investigation.The calculated results reveal that Ce has the most effective modification ability due to the most positive adsorption energy and the largest charge transfer value compared with other rare earth elements.Results of experimental investigation indicate that the addition of rare earth in the Al-5Ti-1B alloys can greatly refine the particle size of TiB2,improve the distribution of particles and lead to better refinement effect than that of the Al-5Ti-1B alloys without rare earth.Moreover,Ce has the best optimization effect,which agrees well with the calculated results.

纳布啡在骨科手术麻醉镇痛中的研究进展

μ阿片受体激动剂临床应用悠久广泛,多年来作为镇痛的主要药物,因其副作用多而影响镇痛效果。纳布啡(Nal)是大部κ阿片受体激动剂和小部分μ阿片受体拮抗剂,该文探求Nal在骨科手术麻醉中的临床应用和研究,以及将来可能的发展方向。综述Nal药学特性、动物实验、小儿及成人患者关于骨科手术麻醉方面的用药情况,证实其镇痛可靠且副作用少、安全性高;预测Nal可用于多种用药方式的镇痛。

低压虹吸系统在经尿道前列腺电切术中的应用

目的探索利用自制膀胱测压预警系统实施低压经尿道前列腺电切术(TURP)的可行性与安全性。方法 2014年1月-2016年1月167例行前列腺电切的前列腺增生(BPH)患者按随机数字表法分为测压组(A组)和非测压组(B组)。A组85例,采用经皮膀胱造瘘+TURP术式42例(A1组),连续冲洗鞘式TURP术式43例(A2组)。B组82例,采用经皮膀胱造瘘+TURP术式42例(B1组),连续冲洗鞘式TURP术式40例(B2组)。A组利用自制虹吸管经膀胱穿刺形成膀胱测压预警系统进行膀胱测压,实时监测膀胱压力,保持膀胱低压状态进行TURP手术。4组均检测术前、术后血Na^+,记录术中手术时间、术中出血量、切除前列腺质量、尿色转清时间,评估手术前后的国际前列腺症状评分(IPSS)、最大尿流率(Qmax)、残余尿量(PVR)和生活质量评分(QOL)。结果 A组血Na^+术前术后差异无统计学意义,B组血Na^+术前术后差异有统计学意义,提示测压组较非测压组更安全。测压组A1与非测压组B1、测压组A2与非测压组B2相比可用于切除前列腺组织的安全手术时间更长、前列腺切除质量更多,术后尿色转清时间更短,Qmax、IPSS改善更佳,提示测压组较非测压组治疗效果更佳。结论自制膀胱测压预警系统可以及时发现TURP术中膀胱内高压状态,可以及时处理造成高压的原因,始终能保持低压冲洗下进行TURP,延长了安全手术时间,增加组织切除率,明显降低电切综合征的发生,使TURP更具安全性。

Rapid rehabilitation technique with integrated traditional Chinese and Western medicine promotes postoperative gastrointestinal function recovery

BACKGROUND During the perioperative period, the characteristic therapy of traditional Chinese medicine is effective in improving postoperative rehabilitation. In large-scale hospitals practicing traditional Chinese medicine, there is accumulating experience related to the promotion of fast recovery in the perioperative period.AIM To evaluate the efficacy and safety of Yikou-Sizi powder hot compress on Shenque acupuncture point combined with rapid rehabilitation technique.METHODS This prospective, multicenter, randomized, controlled study included two groups: Treatment group and control group. The patients in the treatment group and control group received Yikou-Sizi powder hot compress on Shenque acupuncture point combined with rapid rehabilitation technique and routine treatment, respectively. Clinical observation regarding postoperative recovery of gastrointestinal function was performed, including the times to first passage of flatus, first defecation, and first normal bowel sounds. The comparison between groups was conducted through descriptive analysis, χ~2, t, F, and rank-sum tests.RESULTS There was a statistically significant difference in the time to postoperative first defecation between the treatment and control group(87.16 ± 32.09 vs 109.79 ±40.25 h, respectively;P < 0.05). Similarly, the time to initial recovery of bowel sounds in the treatment group was significantly shorter than that in the control group(61.17 ± 26.75 vs 79.19 ± 33.35 h, respectively;P < 0.05). However, there was no statistically significant difference in the time to initial exhaust between the treatment and control groups(51.54 ± 23.66 vs 62.24 ± 25.95 h, respectively;P >0.05). The hospitalization expenses for the two groups of patients were 62283.45 ±12413.90 and 62059.42 ± 11350.51 yuan, respectively. Although the cost of hospitalization was decreased in the control group, the difference was not statistically significant(P > 0.05). This clinical trial was safe without reports of any adverse reaction or event.CONCLUSION The rapid rehabilitation technique with integrated traditional Chinese and Western medicine promotes the recovery of postoperative gastrointestinal function and is significantly better than standard approach for patients after colorectal surgery.

Effects of Chinese herbal medicine Xiangbin prescription on gastrointestinal motility

AIM To investigate the effects of Xiangbin prescription(XBP), a Chinese herbal concoction, on gastrointestinal motility.METHODS Forty healthy volunteers were recruited for this randomized controlled trial of XBP. Antroduodenojejunal manometry was used to monitor gastrointestinal motility in these subjects. After the subjects had fasted for at least 12 h, XBP(n = 30) or placebo(n = 10) was orally administrated and gastrointestinal motility was recorded for 4 h. Plasma motilin and ghrelin were measured by enzyme-linked immunosorbent assay.RESULTS Oral administration of XBP significantly increased the amplitude of duodenal contractions [19.5(13.0-26.7) vs 16.9(12.3-23.9), P < 0.05], jejunal contractions [18.3(15.3-25.0) vs 15.4(11.7-23.9), P < 0.01], and the motility index of duodenal contractions [522.0(146.0-139.0) vs 281.0(76.5-1006.0), P < 0.01] in phase Ⅱ of the migratory motor complex(MMC), which subsequently initiated the MMC cycle [74.0(30.0-118.0) vs 116.5(24.0-219.0), P < 0.05], shortened the duration of phase I of the MMC [42.0(0.0-90.0) vs 111.5(42.0-171.0), P < 0.01], and lengthened the duration of phase Ⅱ of the MMC [120(21-240) vs 58(16-170), P < 0.01] compared to the duration before XBP administration. There were significant differences in the amplitude of jejunal contractions [19.8(14.0-30.0) vs 18.0(13.0-28.5), P < 0.05], the motility index of duodenal contractions [236.0(115.0-306.0) vs 195.0(109.0-310.0), P < 0.05], and jejunal contractions [214.0(95.0-403.0) vs 178.0(55.0-304.0), P < 0.01] in phase Ⅲ of the MMC. Oral administration of XBP greatly increased plasma motilin(57.69 ± 9.03 vs 49.38 ± 8.63, P < 0.01) and ghrelin(279.20 ± 104.31 vs 238.73 ± 115.59, P < 0.01) concentrations compared to concentrations after oral administration of the placebo.CONCLUSION XBP can stimulate duodenal and jejunal motility and increase the concentrations of plasma motilin and ghrelin. The clinical applicability of XBP in treating GDIM deserves investigation.

Benchmarking of JEFF-3.2, FENDL-3.0 and TENDL-2014 evaluated data for tungsten with 14.8 MeV neutrons

Integral experiments on tungsten slab samples were carried out on the D-T neutron source facility at China Institute of Atomic Energy. Leakage neutron spectra from the irradiated tungsten target were measured by the time-of-flight technique. Accuracy of the nuclear data for tungsten was examined by comparing the measured neutron spectra with the leakage neutron spectra simulated using the MCNP-4C code with evaluated nuclear data of the JEFF-3.2, FENDL-3.0 and TENDL-2014 libraries. The results show that the calculations with JEFF-3.2 agree well with the measurements in the whole energy range and all angles, whereas the spectra calculated with FENDL-3.0 and TENDL-2014 have some discrepancies with the experimental data.

Recent progress in nuclear data measurement for ADS at IMP

Recent progress in nuclear data measurement for ADS at Institute of Modern Physics is reviewed briefly.Based on the cooler storage ring of the Heavy Ion Research Facility in Lanzhou, nuclear data terminal was established.The nuclear data measurement facility for the ADS spallation target has been constructed, which provides a very important platform for the experimental measurements of spallation reactions. A number of experiments have been conducted in the nuclear data terminal. A Neutron Time-of-Flight(NTOF)spectrometer was developed for the study of neutron production from spallation reactions related to the ADS project.The experiments of 400 MeV/u ^(16)O bombarded on a tungsten target were presented using a NTOF spectrometer.Neutron yields for 250 MeV protons incident on a thick grain-made tungsten target and a thick solid lead target have been measured using the water-bath neutron activation method. Spallation residual productions were studied by bombarding W and Pb targets with a 250 MeV proton beam using the neutron activation method. Benchmarking of evaluated nuclear data libraries was performed for D-T neutrons on ADS relevant materials by using the benchmark experimental facility at the China Institute of Atomic Energy.

Development and validation of the perioperative recovery scale for integrative medicine

Purpose: The aim of this study is to develop and validate a scale for perioperative recovery with integrative medicine. Methods: The procedures for developing the scale included a review of both modern and ancient literature, other perioperative scales or questionnaire references, an expert consultation, and interviews with patients and surgeons following standard procedures. Primary face and content validity were assessed through a small-scale patient survey of 50 patients. A final evaluation based on the patient survey was conducted among 354 patients (age range 16-75) from the same hospital. This included testing the perioperative recovery scale for integrative medicine (PRSIM) for scaling properties, reliability, validity and responsiveness. Results: The PRSIM, a 20-item scale, was modified from an initial version transcript which included 122 items. The 20 items in the PRSIM covered five domains: direct influence, indirect influence, activity, mental function and general health perceptions. Five factors extracted from an exploratory factor analysis demonstrated a desirable model fit. A confirmatory factor analysis further indicated that the PRSIM had a good fit with the same sample. A data analysis of the PRSIM with 349 patients showed that it had good internal consistency (α> 0.7), test-retest reliability (ICC > 0.4) and split half reliability (α= 0.66). Conclusions: The PRSIM can serve as a valuable instrument for assessing patient perioperative recovery in integrative medicine. It is acceptable for patients in the perioperative period undergoing treatment by either Chinese or integrative medicine, and has good psychometric properties. Registration number: ChiCTR-TRC-09000527.

A curve-based material recognition method in MeV dual-energy X-ray imaging system

High-energy dual-energy X-ray digital radiography imaging is mainly used in the material recognition of cargo inspection. We introduce the development history and principle of the technology and describe the data process flow of our system. The system corrects original data to get a dual-energy transparence image. Material categories of all points in the image are identified by the classification curve,which is related to the X-ray energy spectrum. For the calibration of classification curve, our strategy involves a basic curve calibration and a real-time correction devoted to enhancing the classification accuracy. Image segmentation and denoising methods are applied to smooth the image. The image contains more information after colorization. Some results show that our methods achieve the desired effect.

Xiangbinfang granules enhance gastric antrum motility via intramuscular interstitial cells of Cajal in mice

BACKGROUND Interdigestive migrating motor complexes(MMC)produce periodic contractions in the gastrointestinal tract,but the exact mechanism of action still remains unclear.Intramuscular interstitial cells of Cajal(ICC-IM)participate in gastrointestinal hormone and neuromodulation,but the correlation between ICCIM and MMC is also unclear.We found that xiangbinfang granules(XBF)mediated the phase III contraction of MMC.Here,the effects of XBF on gastric antrum motility in W/Wv mice and the effects of ICC-IM on gastric antrum MMC are reported.AIM To observe the effects of ICC-IM on gastric antrum motility and to establish the mechanism of XBF in promoting gastric antrum motility.METHODS The density of c-kit-positive ICC myenteric plexus(ICC-MP)and ICC-IM in the antral muscularis of W/Wv and wild-type(WT)mice was examined by confocal microscopy.The effects of XBF on gastric antrum slow waves in W/Wv and WT mice were recorded by intracellular amplification recording.Micro-strain-gauge force transducers were implanted into the gastric antrum to monitor the MMC and the effect of XBF on gastric antrum motility in conscious W/Wv and WT mice.RESULTS In the gastric antrum of W/Wv mice,c-kit immunoreactivity was significantly reduced,and no ICC-IM network was observed.Spontaneous rhythmic slow waves also appeared in the antrum of W/Wv mice,but the amplitude of the antrum slow wave decreased significantly in W/Wv mice(22.62±2.23 mV vs 2.92±0.52 mV,P<0.0001).MMCs were found in 7 of the 8 WT mice but no complete MMC cycle was found in W/Wv mice.The contractile frequency and amplitude index of the gastric antrum were significantly increased in conscious WT compared to W/Wv mice(frequency,3.53±0.18 cpm vs 1.28±0.12 cpm;amplitude index,23014.26±1798.65 mV·20 min vs 3782.16±407.13 mV·20 min;P<0.0001).XBF depolarized smooth muscle cells of the gastric antrum in WT and W/Wv mice in a dose-dependent manner.Similarly,the gastric antrum motility in WT mice was significantly increased after treatment with XBF 5 mg(P<0.05).Atropine(0.1 mg/kg)blocked the enhancement of XBF in WT and W/Wv mice completely,while tetrodotoxin(0.05 mg/kg)partially inhibited the enhancement by XBF.CONCLUSION ICC-IM participates in the regulation of gastric antrum MMC in mice.XBF induces MMC III-like contractions that enhance gastric antrum motility via ICCIM in mice.

INVERSE OPALINE STRUCTURE TITANIA PHOTONIC CRYSTALS BY FUNCTIONALLY MODIFIED COLLOIDAL CRYSTALS TEMPLATING

Ordered macroporous titania photonic crystals （PCs） and photonic balls were fabricated by functional modified polymer colloidal crystals. The TiO2 PCs and balls formed through this method exhibit no cracks and lacunae in large areas on their surface and their inner structures.

Performance of digital data acquisition system in gamma-ray spectroscopy

A newly developed digital data acquisition system,which is based on the digital pulse processor Pixie-16 modules by XIA LLC,was tested with the c-ray detector array of the China Institute of Atomic Energy using the cray source and in-beam c-rays.A comparison between this digital data acquisition system and the conventional analog data acquisition system was made.At a low count rate,both systems exhibit good and comparable energy resolutions.At a high count rate above 8.8 k/s,while the energy resolution obtained by the analog system deteriorates significantly,the energy resolution obtained by the digital system is nearly unchanged.Meanwhile,experimental data with higher statistics can be collected by the digital system.The advantage of this digital system over the conventional analog system can be ascribed to its excellent capability of handling pile-up pulses at higher count rates,and the fact that it has nearly no dead time in data transmission and conversion.

mRNA Expression of Chemokine Receptors on Peripheral Blood Mononuclear Cells and Correlation with Clinical Features in Systemic Lupus Erythematosus Patients

Objective To investigate the expressions of chemokine receptors and interleukin （IL） receptors on the peripheral blood mononuclear cells （PBMCs） from systemic lupus erythematosus （SLE） patients and their correlations with clinical features as well as SLE disease activity index （SLEDAI）. Methods The mRNA expressions of chemokine receptors and IL receptors on PBMCs of 93 SLE patients and 30 healthy controls were detected by reverse transcription-polymerase chain reaction, including CCR2, CCR3, CCR4, CCR5, CCR6, CCR8, CXCR3, CXCR5, CX3CR1, XCR1, IL-4R, and IL-10R. The clinical features of SLE patients were recorded. The correlations of chemokine receptors and IL receptors mRNA expressions with clinical features as well as SLEDAI were assayed using linear regression analysis. Results The level of CCR5 mRNA in SLE patients （including active and inactive SLE） was signifi- cantly higher than that in healthy controls （P〈0.05）, and there was no significant difference between active and inactive patients in this respect （P〉0.05）. CX3CR1 mRNA expression significantly increased from healthy control to inactive SLE to active SLE in sequence. The others （except for CCR8, CXCR3, and IL-1 OR） in active SLE patients weresignificantly higher than those in both inactive SLE patients and healthy controls （all P〈0.05）. There were positive correlations between SLEDAI and CCR2 （r=0.424, t=4.313, P〈0.001）, CCR3 （r=0.518, t=5.410, P〈0.001）, CCR4 （r=0.376, t=3.851, P〈0.001）, CCR6 （r=0.457, t=4.513,P〈0.001）, CXCR5 （r=0.455, t=4.629, P〈0.001）, CX3CR1 （r=0.44-5, t=4.523, P〈0.001）, as well as XCRI （r=0.540, t=5.445, P〈0.001）. And CCR5 mRNA expression level was positively correlated with IL-4R mRNA （r=0.313, t=2.353, P〈0.05）. The patients with myositis and cutaneous vasculitis simultaneously showed lower levels of CCR5 and CX3CRI, and CCR5 expression was negatively correlated with the scores of SLEDAI in SLE cases accompanied by photosensitivity （r=0.426, t=- 2.155, P〈0.05）. Conclusion Increased expressions of CCR5 and CX3CRI on PBMCs may be indicators in clinical survey for SLE.

A rare type of choledochal cysts of Todani type IV-B with typical pancreaticobiliary maljunction

Choledochal cysts(CCs),first described by Vater and Ezler in 1723,are rare congenital cystic dilations of biliary tract[1].The most widely adopted classification system from Todani et al.divides CCs into five major types and several subtypes[2].Almost all of the CCs are type I and type IV-A,while type IV-B is extremely rare[3,4].The accurate diagnosis and precise categorization of CCs are crucial for surgeons to perform proper operative strategy.

miR-206 Inhibits Renal Cell Cancer Growth by Targeting GAK

Renal cell cancer(RCC)remains one of the most lethal types of cancer in adults.Micro RNAs(mi RNAs)play key roles in the pathogenesis of RCC.The role of mi R-206 in RCC has not been fully understood.The purpose of this study was to examine the role of mi R-206 in the regulation of proliferation and metastasis of RCC and the possible mechanism.mi R-206 expression was detected by reverse transcription?quantitative polymerase chain reaction(RT-q PCR)in RCC cell lines(786-O and OS-RC-2 cells)and clinical samples.MTS[3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium]method,colony formation and transwell assay were used to detect the tumor-suppressing ability of mi R-206 in RCC.Luciferase assay was performed to verify the precise target of mi R-206.The results showed that the expression of mi R-206 was significantly down-regulated in RCC tissues and cells.The expression level of cyclin G-associated kinase(GAK),a master regulator of tumor proliferation and metastasis,was up-regulated with the decrease in mi R-206 in RCC tissues as well as RCC cell lines.In addition,the mi R-206 inhibitor promoted the proliferation,migration and invasion of 786-O and OS-RC-2 cells.Bioinformatics combined with luciferase and Western blot assays revealed that mi R-206 inhibited the expression of GAK.Moreover,mi R-206 regulates RCC cell growth partly through targeting GAK.Our study indicated that mi R-206 functions as a tumor suppressor in regulating the proliferation,migration and invasion of RCC by directly targeting GAK,and it holds promises as a potential therapeutic target for RCC.

性激素比值预测特发性少精子症愈后的意义

目的通过分析不同疗效组间促卵泡生成素(FSH)与促黄体生成素(LH)的比值和睾酮(T)与LH的比值有无区别,探讨性激素内部比值对他莫昔芬治疗特发性少精子症疗效有无临床预测意义。方法筛选出性激素单项指标均在正常范围,经过他莫昔芬治疗呈现不同疗效的特发性少精子症患者131例,分为3组:治愈组49例、改善组36例、无效组46例。回顾性分析各组治疗前性激素内部比值水平(FSH/LH和T/LH)及单项指标有无区别。结果治愈组、有效组、无效组3组的FSH/LH比值分别为(1.163±0.409)、(1.478±0.524)、(1.930±0.558),3组比较差异有统计学意义(P <0.05),任意两组间经LSD-t检验差异有统计学意义(P <0.05);治愈组、有效组、无效组3组的T/LH比值分别为(3.931±1.432)、(3.438±1.583)、(3.165±1.522),3组比较差异有统计学意义(P <0.05),其中治愈组和无效组间比较差异有统计学意义(P <0.05);单项指标FSH 3组比较差异有统计学意义(P <0.05),但3组间LH和T指标比较差异无统计学意义(P>0.05),仅LH值治愈组和无效组比较差异有统计学意义(P <0.05)。结论与性激素单项检测指标比较,内部比值(FSH/LH和T/LH)对他莫昔芬治疗特发性少精子症的愈后判断更有临床意义。

An active base designed in high-counting-rate applications for Hamamatsu R1924A photomultiplier tube

Hamamatsu R1924A is one of the most widely used photomultiplier tubes(PMTs) in nuclear physics.Since the active base suitable for R1924A is still not available in market, an active base is designed for Hamamatsu R1924A PMT, and the test results at high counting rates are presented. The active bases with two different sets of resistor chains were tested and compared by a frequency-controlled green straw hat LED light. A stable signal output up to 100 kHz is achieved using frequency-controlled LED pulsed light. The temperature of bases, which reflects the power consumption and is crucial for applications in vacuum, is also monitored with the same LED pulsed light. The temperature of the active base with smaller resistances reaches about twice of that of the active base with larger resistances in the resistor chain. For the applications in vacuum, the active base with resistance between the two sets of resistor chains may be preferable.

Simulation of gamma minitype reference radiation for calibration of personal dosimeter

An investigation using Monte Carlo simulation on a minitype reference radiation(MRR) for the calibration of gamma personal dosimeters is reported. The distributions of dose rate and scattering gamma spectrum are the main simulation objects with the variable physical structures of MRR and the dosimeters as parameters that are to be calibrated. Further, the influences on the reference radiation caused by these parameters are analyzed in detail.This work provides a theoretical basis for better understanding of MRR used for calibration of gamma personal dosimeters. This analysis can help in the development of a calibration technology for such tools based on MRR.

Effective components and signaling pathways of Ranunculi Ternati Radix based on network pharmacology

Objective:This study was designed to find out the active components of Ranunculi Ternati Radix using network pharmacology,and to explore its potential target and pharmacological mechanism.Methods:By the TCMSP database,combined with oral bioavailability(≥30%)analysis and resistance(≥0.18),screening of active ingredients in Ranunculus ternatus Thunb.Retrieve the protein targets of the compounds from the TCMSP database.Associated Proteins and Gene Names were received via UniProt database.The protein interaction network was constructed by applying String database and Cytoscape software.Gene Ontology and Pathway Enrichment Analysis were developed on the basis of DAVID database.Results:10 active compounds including beta-sitosterol,campesterol,Mandenol were selected from Ranunculi Ternati Radix.And it produced its effects on different diseases mainly by regulating targets including PIK3CG,HSP90AA1,BAX and BCL2,which involved signaling pathways containing Pathways in cancer、PI3K-Akt signaling pathway、Hepatitis B、Tuberculosis and so on.Some published papers had confirmed by each other.Meanwhile,this work predics that Ranunculi Ternati Radix had the potential to treat non-alcoholic fatty liver disease.Conclusion:This study preliminarily validated the major targets and pathways of Ranunculi Ternati Radix acting on different diseases,which laid a foundation for further study on its mechanisms.

Effect of interleukin-23 on inflammation response and oxidative stress in rats with myocardial ischemia reperfusion injury

Objective: To investigate the effect of interleukin-23 (IL-23) on myocardial ischemia-reperfusion (I/R) injury.Methods: Male Sprague-Dawley rats were randomly assigned into sham operated control (SO) group, ischemia and reperfusion (I/R) group, (IL-23 + I/R) group and (anti-IL-23 + I/R) group. At 4 h after reperfusion, the serum concentration of lactate dehydrogenase (LDH), creatine kinase (CK) and the tissue MDA concentration and SOD activity were measured. The infarcte size was measured by TTC staining. Apoptosis in heart sections were measured by TUNEL staining. The expression of HMGB1 and IL-17A were detected by Western Blotting and the expression of TNF-α and IL-6 were detected by Elisa. Results: After 4 h reperfusion, compared with the I/R group, IL-23 significantly increased the infarct size, the apoptosis of cardiomyocytes and the levels of LDH and CK. Meanwhile, IL-23 significantly increased the expression of eIL-17A, TNF-α and IL-6 and enhanced both the increase of the MDA level and the decrease of the SOD level induced by I/R. IL-23 had no effect on the expression of HMGB1. All these effects were abolished by anti-IL-23 administration. Conclusion: The present study suggested that IL-23 may promote myocardial I/R injury by increasing the inflammatory responses and oxidative stress reaction.