The pore structure and oil content of shales have an important influence on the oil mobility and enrichment.In this study,the lacustrine shale samples from the Qingshankou Formation(Q1)of Songliao Basin were selected....The pore structure and oil content of shales have an important influence on the oil mobility and enrichment.In this study,the lacustrine shale samples from the Qingshankou Formation(Q1)of Songliao Basin were selected.TOC,pyrolysis,XRD and nitrogen adsorption were performed on the original and extracted shale samples.Then the influence of mineral composition and organic matter(OM)on the development of nano-scale pore,the oil phase states and mobility were analyzed.The Q1 shale samples can be sub-divided into three types according to the isotherm characteristics.Type A samples are characterized by high kerogen content,with oil mainly existing in the free phase state.Type B samples are characterized by medium kerogen content,oil mainly exists in the absorbed phase state.Type C samples are characterized by low kerogen content,with trace oil found in the absorbed phase state.Nano-scale organic pores are well developed in the Q1 Formation.Oil is primarily found in the pore spaces with diameters less than 10 nm,this being the pore size threshold for mobile shale oil.When TOC>2.0 wt%and EOM>1.0 wt%,Q1 Formation shale oil mobility is high,resulting in prospective drilling targets.展开更多
Objective:To explore the clinical characteristics,surgical treatment and prognosis of nonsmall cell lung cancer(NSCLC) among elderly patients over 80 years.Methods:The clinical data,surgical methods,perioperative mana...Objective:To explore the clinical characteristics,surgical treatment and prognosis of nonsmall cell lung cancer(NSCLC) among elderly patients over 80 years.Methods:The clinical data,surgical methods,perioperative management,postoperative complications and prognosis of 52 NSCLC patients aged over 80 years were retrospectively analyzed.Results:Out of 52 cases, 27 had a long-term smoking history(51.9%) and 44 were with other diseases(84.6%).Lobectomy was done in 32 cases(65.4%),sub-lobectomy in 20 cases(38.5%),including pulmonary wedge resection in 16 cases(30.8%) and lung segment resection in 4 cases(7.7%).The postoperative complication rate was 44.2%(23/52);the complication rate after lobectomy was 62.5%(20/32) and that after sub-lobectomy was 25%(5/20),with significant difference between lobectomy and sublobectomy (P【0.05).Postoperative mortality was 3.8%(2/52).Pathological TNM staging:Ⅰa 27 cases(51.9%),Ⅰb 12 cases(23.1%),Ⅱa 8 cases(15.4%),Ⅱb 3 cases(5.8%) andⅢ2 cases(3.8%). The 1-,3- and 5-year survival rate after operation was 87.1%,59.8%,19.1%.The 1-,3- and 5-year survival rate was 86.0%,61.8%,21.5%in the patients after lobectomy,that was 89.0%,58.3%, 18.7%in the patients after sub-lobectomy,with no significant difference between two surgical methods(P】0.05).Conclusions:Octogenarians with NSCLC are often afflicted with comorbidity, so perioperative management is more complex.Strictly adhering to indications,surgery is still an important treatment of NSCLC patients over 80.展开更多
Dear Editor,Extracellular vesicles,especially exosomes,have emerged as promising diagnostic sources for cancers due to their easy and quick accessibility.1,2 Additionally,it has been demonstrated that circulating miRN...Dear Editor,Extracellular vesicles,especially exosomes,have emerged as promising diagnostic sources for cancers due to their easy and quick accessibility.1,2 Additionally,it has been demonstrated that circulating miRNAs serve as promising biomarkers for the diagnosis of multiple diseases.3,4 Cholangiocarcinoma(CCA)and gallbladder carcinoma(GBC)are two malignant biliary tract cancers.It has been estimated that patients with unresectable GBC have a 5-year survival of only less than 5%,while CCA patients suffer from an overall 5-year survival of~10%.5 Hence,circulating diagnostic biomarkers would benefit the diagnosis and treatment of GBC and CCA patients.We sequenced exosomal small RNA from five CCA patients and four GBC patients before and after surgery and enrolled 40 healthy individuals,45 more CCA patients and 24 more GBC patients to validate the sequencing results to identify diagnostic biomarkers for GBC and CCA.展开更多
基金financially supported by the National Natural Science Foundation of China(No.41972156)the Science and Technology Project of Heilongjiang Province(No.2020ZX05A01)
文摘The pore structure and oil content of shales have an important influence on the oil mobility and enrichment.In this study,the lacustrine shale samples from the Qingshankou Formation(Q1)of Songliao Basin were selected.TOC,pyrolysis,XRD and nitrogen adsorption were performed on the original and extracted shale samples.Then the influence of mineral composition and organic matter(OM)on the development of nano-scale pore,the oil phase states and mobility were analyzed.The Q1 shale samples can be sub-divided into three types according to the isotherm characteristics.Type A samples are characterized by high kerogen content,with oil mainly existing in the free phase state.Type B samples are characterized by medium kerogen content,oil mainly exists in the absorbed phase state.Type C samples are characterized by low kerogen content,with trace oil found in the absorbed phase state.Nano-scale organic pores are well developed in the Q1 Formation.Oil is primarily found in the pore spaces with diameters less than 10 nm,this being the pore size threshold for mobile shale oil.When TOC>2.0 wt%and EOM>1.0 wt%,Q1 Formation shale oil mobility is high,resulting in prospective drilling targets.
文摘Objective:To explore the clinical characteristics,surgical treatment and prognosis of nonsmall cell lung cancer(NSCLC) among elderly patients over 80 years.Methods:The clinical data,surgical methods,perioperative management,postoperative complications and prognosis of 52 NSCLC patients aged over 80 years were retrospectively analyzed.Results:Out of 52 cases, 27 had a long-term smoking history(51.9%) and 44 were with other diseases(84.6%).Lobectomy was done in 32 cases(65.4%),sub-lobectomy in 20 cases(38.5%),including pulmonary wedge resection in 16 cases(30.8%) and lung segment resection in 4 cases(7.7%).The postoperative complication rate was 44.2%(23/52);the complication rate after lobectomy was 62.5%(20/32) and that after sub-lobectomy was 25%(5/20),with significant difference between lobectomy and sublobectomy (P【0.05).Postoperative mortality was 3.8%(2/52).Pathological TNM staging:Ⅰa 27 cases(51.9%),Ⅰb 12 cases(23.1%),Ⅱa 8 cases(15.4%),Ⅱb 3 cases(5.8%) andⅢ2 cases(3.8%). The 1-,3- and 5-year survival rate after operation was 87.1%,59.8%,19.1%.The 1-,3- and 5-year survival rate was 86.0%,61.8%,21.5%in the patients after lobectomy,that was 89.0%,58.3%, 18.7%in the patients after sub-lobectomy,with no significant difference between two surgical methods(P】0.05).Conclusions:Octogenarians with NSCLC are often afflicted with comorbidity, so perioperative management is more complex.Strictly adhering to indications,surgery is still an important treatment of NSCLC patients over 80.
基金supported by the National Natural Science Foundation of China(81772798)National Natural Science Fund Youth Project(81700007)+3 种基金Research and Innovation Fund of the Ministry of Education(2018A03026)Beijing Natural Science Foundation(2019A10)“Qingmiao”Project of Beijing Municipal Hospital Administration(2018QM4)Beijing Top Talent Project(2018000021223ZK11).
文摘Dear Editor,Extracellular vesicles,especially exosomes,have emerged as promising diagnostic sources for cancers due to their easy and quick accessibility.1,2 Additionally,it has been demonstrated that circulating miRNAs serve as promising biomarkers for the diagnosis of multiple diseases.3,4 Cholangiocarcinoma(CCA)and gallbladder carcinoma(GBC)are two malignant biliary tract cancers.It has been estimated that patients with unresectable GBC have a 5-year survival of only less than 5%,while CCA patients suffer from an overall 5-year survival of~10%.5 Hence,circulating diagnostic biomarkers would benefit the diagnosis and treatment of GBC and CCA patients.We sequenced exosomal small RNA from five CCA patients and four GBC patients before and after surgery and enrolled 40 healthy individuals,45 more CCA patients and 24 more GBC patients to validate the sequencing results to identify diagnostic biomarkers for GBC and CCA.
