Raidoprotective 105(RP105)was first discovered on the surface of mouse B cells and it has been demonstrated that RP105 can function as an inflammatory regulator in cardiovascular disease(CVD),such as myocardial ischem...Raidoprotective 105(RP105)was first discovered on the surface of mouse B cells and it has been demonstrated that RP105 can function as an inflammatory regulator in cardiovascular disease(CVD),such as myocardial ischemic reperfusion injury(MI/RI),atherosclerosis and myocardial infarction(MI).As a member of Toll-like receptor(TLR)homolog which is capable of regulating toll-like receptor(TLR4)signaling pathway,RP105 is implicated in various biological processes.Mounting evidence suggests that RP105 regulates the function of TLR4 and phosphoinositide 3-kinase(PI3K)signaling pathways.Here,we review the effect of RP105 on CVD through regulating TLR4/PI3K signaling pathways.展开更多
基金the National Natural Science Foundation of China(No.81770360 and No.81800258).
文摘Raidoprotective 105(RP105)was first discovered on the surface of mouse B cells and it has been demonstrated that RP105 can function as an inflammatory regulator in cardiovascular disease(CVD),such as myocardial ischemic reperfusion injury(MI/RI),atherosclerosis and myocardial infarction(MI).As a member of Toll-like receptor(TLR)homolog which is capable of regulating toll-like receptor(TLR4)signaling pathway,RP105 is implicated in various biological processes.Mounting evidence suggests that RP105 regulates the function of TLR4 and phosphoinositide 3-kinase(PI3K)signaling pathways.Here,we review the effect of RP105 on CVD through regulating TLR4/PI3K signaling pathways.
