Effect of Fe_2B boride orientation on abrasion wear resistance of Fe-B cast alloy

The microstructures and abrasion wear resistance of directional solidification Fe-B alloy have been investigated using optical microscopy, X-ray diffraction, scanning electron microscopy and laser scanning microscopy. The results show that the microstructure of as-cast Fe-B alloy consists of ferrite, pearlite and eutectic boride. After heat treatment, the microstructure is composed of boride and martensite. The plane which is perpendicular to the boride growth direction possesses the highest hardness. In two-body abrasive wear tests, the silicon carbide abrasive can cut the boride and martensite matrix synchronously, and the wear mechanism is micro cutting mechanism. The worn surface roughness and the wear weight loss both increase with the increasing contact load. Moreover, when the boride growth direction is perpendicular to the worn surface, the highest hardness plane of the boride can effectively oppose abrasion, and the martensite matrix can surround and support borides perfectly.

Mills’syndrome is a unique entity of upper motor neuron disease with N-shaped progression:Three case reports

BACKGROUND Mills’syndrome is an extremely rare degenerative motor neuron disorder first described by Mills in 1900,but its nosological status is still not clear.We aimed to analyze the clinical features of Mills’syndrome.CASE SUMMARY Herein,we present 3 cases with similar features as those described in Mills’original paper and review the related literature.Our patients showed middle-and older-age onset,with only upper motor neuron symptoms evident throughout the course of the disease.Spastic hemiplegia began in the lower extremity with a unique progressive pattern.CONCLUSION We consider that Mills’syndrome is a unique entity of motor neuron disorder with an N-shaped progression.Clinicians should maintain a high index of suspicion for the diagnosis of Mills’syndrome when the onset involves lower extremity paralysis without evidence of lower motor neuron or sensory involvement.

穴位效应与神经免疫调控

In recent years,research on acupoints has made significant progresses.Studies on acupoint sensitization have suggested that various changes would appear in specific acupoints in pathological state,including abnormal sensation,tissue deformation,expansion of the acupoint regions,and increased expression of painrelated substances.

Prevention of Local Liver Cancer Recurrence after Surgery Using Multilayered Cisplatin-loaded Polylactide Electrospun Nanofibers

In this study a cisplatin-loaded, multilayered polylactide （PLA） electrospun nanofibers, with the structure of two layers of drug-loaded mat being sandwiched by three layers of blank mat, were designed for prolonged cisplatin release at surgical margin to prevent local cancer recurrence following surgical resection in a murine model. In vivo drug release and biodistribution study suggested that the multilayered fibrous mat displayed a slower cisplatin release behavior and a more stable drug rentention in the local tissue within 24 h than that of single-layered fibrous mat. By covering the surgical site with the multilayered fibrous mat following resection of subcutaneous liver cancer in mice, retarded tumor recurrence, prolonged survival time and less systemic toxicity were observed compared with other treatment groups.

Comparison of the neurovascular microstructure in local skin tissues at “PC3”“PC7” and “PC9” regions in the rat

Objective:The aim of this study was to compare the microstructure of blood vessels and nerve fibers between different acupoints in the rat skin from the perspective of histology.Methods:The skin tissue at"Quze"(曲泽PC3)""Daling(大陵PC7)"and"Zhongchong(中冲PC9)"regions was taken from the rat forelimb along the pericardium meridian,and cut sagittally with a freezing microtome.After that,the skin sections were stained by fluorescent histochemistry and immunohistochemistry with phalloidin and calcitonin gene-related peptide(CGRP)to reveal the microstructure of blood vessels and nerve fibers respectively,and then examined under a laser scanning confocal microscope.Results:The microstructure of blood vessels and nerve fibers was clearly labeled with phalloidin and CGRP,respectively.The blood vessels and nerve fibers were observed in the dermis of"PC3""PC7"and"PC9"regions,where the bundle of nerve fibers distribute in parallel to the blood vessels,and sent out thin branches to surround the wall of the blood vessels.In contrast,the density of blood vessels and nerve fibers in"PC3""PC7"and"PC9"were presented orderly in an increased tendency.Conclusion:The results of present study demonstrate the differences of the neurovascular microstructure among"PC3""PC7"and"PC9"in the rat,providing a histological view to insight into the specificity of different acupoints.