Ecological security pattern-based simulation for land use structure change:a case study in Ezhou City,China

The ecological environment quality is an important constraint and an optimization objective for land resource allocation.Integrating ecological service value(ESV)accounting and ecological security pattern(ESP)delineation,and combining with the land use structure of 2004/2010/2016 in Ezhou City,this research laid out the urban ESP based on ESV with Net Primary Productivity(NPP),and made it as the main influence factor to simulate land use structure in 2022.The results indicated that:1)The water body has the biggest contribution to ESV,while the construction land has the minimum;2)91 ecological corridors are extracted,of which 28 were important ecological corridors;there were 36 ecological nodes extracted,including 17 important nodes;3)According to ESV,Ezhou City was divided into four security zones.The area of ecological restoration zone was the largest,and human activity core zone area was the smallest;4)In the no ESP protection scenarios and ESP protection scenarios separately,the net increase area of construction land is from 868.5 hm^(2) to 52.74 hm^(2) in the ecological core protection area;the construction land in the human activity core area has been increased by 2342.31 hm^(2) in protected scene,766.23 hm^(2) more than that of the unprotected scene.The results show that the division of security zones promoted the relocation of construction land from ecological protection core zone to human activity core zone,which can protect the ecological environment effectively,and the ESP-based simulation can provide the decision-making reference to coordinate the relationship of regional land resource allocation and the ecological environment protection.

Nuclear Aurora kinase A switches m^(6)A reader YTHDC1 to enhance an oncogenic RNA splicing of tumor suppressor RBM4

Aberrant RNA splicing produces alternative isoforms of genes to facilitate tumor progression,yet how this process is regulated by oncogenic signal remains largely unknown.Here,we unveil that non-canonical activation of nuclear AURKA promotes an oncogenic RNA splicing of tumor suppressor RBM4 directed by m^(6)A reader YTHDC1 in lung cancer.Nuclear translocation of AURKA is a prerequisite for RNA aberrant splicing,specifically triggering RBM4 splicing from the full isoform(RBM4-FL)to the short isoform(RBM4-S)in a kinase-independent manner.

Targeting cancer cell plasticity by HDAC inhibition to reverse EBV-induced dedifferentiation in nasopharyngeal carcinoma

Application of differentiation therapy targeting cellular plasticity for the treatment of solid malignancies has been lagging.Nasopharyngeal carci noma(NPC)is a distinctive cancer with poor differe ntiatio n and high prevalenee of Epstein-Barr virus(EBV)infection.Here,we show that the expressi on of EBV latent protein LMP1 in duces dediffere ntiated and stem-like status with high plasticity through the transcriptional inhibition of CEBPA.Mechanistically,LMP1 upregulates STAT5A and recruits HDAC 1/2 to the CEBPA locus to reduce its histone acetylation.HDAC inhibition restored CEBPA expression,reversing cellular dedifferentiation and stem-like status in mouse xeno graft models.These fin dings provide a novel mecha nistic epigenetic-based in sight into virus-induced cellular plasticity and propose a promising concept of differentiation therapy in solid tumor by using HDAC inhibitors to target cellular plasticity.