Clinical Utility of Amlodipine/Valsartan Fixed-Dose Combination in the Management of Hypertension in Chinese Patients

Amlodipine/valsartan(Aml/Val)single-pill combination(SPC)therapy has been widely used and studied in clinical practice in recent years.This article reviews the Chinese and English literature on the clinical use of Aml/Val SPC therapy in Chinese hypertensive patients.According to five studies concerning the efficacy and safety of this treatment,Aml/Val SPC therapy was more efficacious than monotherapy with valsartan,amlodipine,or the nifedipine gastrointestinal therapeutic system.This treatment showed greater blood pressure-lowering effects,a higher blood pressure control rate,and a higher response rate.Aml/Val SPC treatment was well tolerated,with adverse event rates similar to those of monotherapy with valsartan or amlodipine and significantly rarer adverse events compared with the nifedipine gastrointestinal therapeutic system.Aml/Val SPC is a highly efficacious and well-tolerated antihypertensive treatment in Chinese hypertensive patients.

Two-stage matrix-assisted glare suppression at a large scale

Scattering-induced glares hinder the detection of weak objects in various scenarios.Recent advances in wavefront shaping show one can not only enhance intensities through constructive interference but also suppress glares within a targeted region via destructive interference.However,due to the lack of a physical model and mathematical guidance,existing approaches have generally adopted a feedback-based scheme,which requires timeconsuming hardware iteration.Moreover,glare suppression with up to tens of speckles was demonstrated by controlling thousands of independent elements.Here,we reported the development of a method named twostage matrix-assisted glare suppression(TAGS),which is capable of suppressing glares at a large scale without triggering time-consuming hardware iteration.By using the TAGS,we experimentally darkened an area containing 100 speckles by controlling only 100 independent elements,achieving an average intensity of only 0.11 of the original value.It is also noticeable that the TAGS is computationally efficient,which only takes 0.35 s to retrieve the matrix and 0.11 s to synthesize the wavefront.With the same number of independent controls,further demonstrations on suppressing larger scales up to 256 speckles were also reported.We envision that the superior performance of the TAGS at a large scale can be beneficial to a variety of demanding imaging tasks under a scattering environment.