Great Wall Motor(GWM),a leading automotive manufacturer,places a strong emphasis on environmental sustainability and social responsibility.The company focuses on comprehensively evaluating and enhancing its supply cha...Great Wall Motor(GWM),a leading automotive manufacturer,places a strong emphasis on environmental sustainability and social responsibility.The company focuses on comprehensively evaluating and enhancing its supply chain to align with these objectives.This evaluation spans the entire product life cycle,encompassing design,manufacturing,packaging,distribution,usage,and recycling and disposal processes.Key areas of focus include optimizing raw material selection,improving product recyclability,reducing energy consumption and waste emissions,and minimizing carbon emissions during transportation.Through these endeavors,GWM not only enhances its environmental performance by reducing carbon emissions and resource consumption but also bolsters its brand image and competitiveness in the market.GWM’s dedication to environmental innovation and technological leadership serves as a driving force behind sustainable development and social responsibility within the industry.展开更多
The Feixianguan formation in the Kaijiang-Liangping basin has been the focus of extensive research on multiple aspects. Based on field survey, core observation, laboratory analysis and seismic data interpretation, the...The Feixianguan formation in the Kaijiang-Liangping basin has been the focus of extensive research on multiple aspects. Based on field survey, core observation, laboratory analysis and seismic data interpretation, the sequence stratigraphy and sedimentary facies of the Kaijiang-Liangping area are studied. Four sequence boundaries and three maximum flooding surfaces of the Feixianguan formation are detected in this area. Three third-order sequences are identified as first sequence (SQ1), the second sequence (SQ2), and the third sequence (SQ3) in which SQ1 corresponds to the member 1 of the Feixianguan formation, SQ2 corresponds to the member 2, and SQ3 corresponds to the member 3 and member 4. Member 1, 2, 3 and 4 are lithologic sections divided by predecessors. On the basis of this sequence division and their sedimentary marks, the facies of the Feixianguan formation can be divided into open platform and evaporate platform categories. The open platform is composed of three subfacies identified as platform bank or basin marginal bank, interbank, and platform basin. Thus, a sedimentary evolution model is established. According to the sedimentary and seismic characteristics of the Kaijiang-Liangping area, we determine that two oolitic bank models, the aggradation model and the progradation model, are developed in this area. The aggradation model is developed in the Longgang region, which includes the basin marginal bank as a favorable exploring zone. The progradation model is developed in the Jiulongshan and Longhui areas, besides the basin marginal bank, the favorable exploration zones also include the oolitic bank developing areas of the inner basin.展开更多
<strong>Objective: </strong>The quantum dots are the useful materials in microelectronics and biomedical research. However its toxicity has to be considered. We studied the effect of cell inhibition with Z...<strong>Objective: </strong>The quantum dots are the useful materials in microelectronics and biomedical research. However its toxicity has to be considered. We studied the effect of cell inhibition with ZnS core quantum dots and CdTe quantum dots modified with Thioglycolic acid or Cysteine functional group (TGA-CdTe, TGA-CdTe/ZnS, Cys-CdTe, Cys-CdTe/ZnS) on Caco-2 cell proliferation. <strong>Methods</strong>: We studied the effect of cell inhibition with ZnS core QDs and CdTe QDs modified with functional group on Caco-2 cell proliferation by MTT assay at 0, 12.5, 25, 50, 100 μg/ml and 6, 24, 48 h. <strong>Result:</strong> Our results showed that all QDs have inhibited cell proliferation and reached maximum 79.21%. The inhibition rate of Cys-modified QDs increased with the increase of concentration and reached maximum 66.72%. The inhibition rate of TGA-modified QDs increased with the increase of time. The ratios of Cys-modified to TGA-modified were less than 1 at all concentrations and three exposure times (P ≤ 0.01). The average ratios of Cys-CdTe/ZnS to Cys-CdTe reached 1.11 only for 48 h (P ≤ 0.05). The ratios of TGA-CdTe/ZnS to TGA-CdTe were closed to 1 at all concentrations and exposure times. <strong>Conclusion:</strong> The regularity of QDs modified with functional group is that inhibition of TGA-modified higher than Cys-modified. Inhibition exhibited dose-dependent for Cys-modified while exhibited time-dependent for TGA-modified. The regularity of CdTe-QDs with ZnS or not is that the inhibition of Cys-CdTe/ZnS was higher than Cys-CdTe while TGA-CdTe/ZnS and TGA-CdTe were consistent.展开更多
The traditional super-resolution direction finding methods based on sparse recovery need to divide the estimation space into several discrete angle grids, which will bring the final result some error. To this problem,...The traditional super-resolution direction finding methods based on sparse recovery need to divide the estimation space into several discrete angle grids, which will bring the final result some error. To this problem, a novel method for wideband signals by sparse recovery in the frequency domain is proposed.The optimization functions are found and solved by the received data at every frequency, on this basis, the sparse support set is obtained, then the direction of arrival(DOA) is acquired by integrating the information of all frequency bins, and the initial signal can also be recovered. This method avoids the error caused by sparse recovery methods based on grid division, and the degree of freedom is also expanded by array transformation, especially it has a preferable performance under the circumstances of a small number of snapshots and a low signal to noise ratio(SNR).展开更多
For the direction of arrival(DOA) estimation,traditional sparse reconstruction methods for wideband signals usually need many iteration times.For this problem,a new method for two-dimensional wideband signals based on...For the direction of arrival(DOA) estimation,traditional sparse reconstruction methods for wideband signals usually need many iteration times.For this problem,a new method for two-dimensional wideband signals based on block sparse reconstruction is proposed.First,a prolate spheroidal wave function(PSWF) is used to fit the wideband signals,then the block sparse reconstruction technology is employed for DOA estimation.The proposed method uses orthogonalization to choose the matching atoms,ensuring that the residual components correspond to the minimum absolute value.Meanwhile,the vectors obtained by iteration are back-disposed according to the corresponding atomic matching rules,so the extra atoms are abandoned in the course of iteration,and the residual components of current iteration are reduced.Thus the original sparse signals are reconstructed.The proposed method reduces iteration times comparing with the traditional reconstruction methods,and the estimation precision is better than the classical two-sided correlation transformation(TCT)algorithm when the snapshot is small or the signal-to-noise ratio(SNR) is low.展开更多
Wood and wood-based composite materials have gained increasing attention in the sustainable building industry because of their renewability and environmental friendliness.Oriented oblique strand lumber(Eucalyptus Stra...Wood and wood-based composite materials have gained increasing attention in the sustainable building industry because of their renewability and environmental friendliness.Oriented oblique strand lumber(Eucalyptus Strand Wood,ESWood),which is manufactured from fast-growing small diameter eucalyptus wood(Eucalyptus urophylla×E.grandis),is introduced in this paper.Small clear specimen tests were conducted to determine the mechanical properties of ESWood material while full-scale component tests were performed to observe the structural performance of ESWood beams.A comparison of mechanical properties of ESWood with other wood/bamboo-based materials is then reported.From the results presented herein,it appears that the strength and stiffness properties of ESWood are affected by grain directionality and glued layers.However,it still has preferable mechanical properties as a building material,which is comparable or superior to those of other engineered wood/bamboo-based products(e.g.,Sitka spruce,LVL,OSL,Glulam,and Glubam).Furthermore,results from full-scale component tests show the stable mechanical performance of beams made by ESWood.This study makes a significant contribution to a potential utilization of fast-growing eucalyptus for general use in construction,and the presented mechanical tests results can serve as a fundamental data for more applications of ESWood in practical engineering.展开更多
With the widespread deployment of biometric recognition,personal data security and privacy are attracted more and more attentions.A crucial privacy issue is how to ensure the security of user template.This paper propo...With the widespread deployment of biometric recognition,personal data security and privacy are attracted more and more attentions.A crucial privacy issue is how to ensure the security of user template.This paper proposes a novel template protection algorithm for face recognition based on chaotic map.Each face template is corresponding to different chaotic sequence produced by system master key and user identification number.The order of chaotic sequence controls the substitution index of face template.Experiment results on facial FERET database show that our algorithm can significantly improve the recognition performance and ensure the security of face template.展开更多
This paper brings forward a method of experimental teaching reform of universities and colleges,which establishes an interactive simulation experiment platform with MATLAB simulation software.The platform uses visual ...This paper brings forward a method of experimental teaching reform of universities and colleges,which establishes an interactive simulation experiment platform with MATLAB simulation software.The platform uses visual man-machine interface,which avoids a lot of programming and debugging work,and improves students’learning enthusiasm.Simultaneously,it implements remote simulation based on JAVA under web environment,which is convenient for network teaching,and improves flexibility and practicability of the simulation experiment platform.展开更多
As the rapid development of information technology represented by mobile internet,internet of things,social computing,society has entered the age of big data,information technology and education teaching are also merg...As the rapid development of information technology represented by mobile internet,internet of things,social computing,society has entered the age of big data,information technology and education teaching are also merged gradually,microlecture as a new application of education and teaching took the wide attention of scholars.This paper analyzes the disadvantages of PAD class and takes microlecture to apply to two stage of PAD class.展开更多
The accurate delivery of nanoparticles and organic small molecule drugs remains a serious challenge in nanoparticle-based tumor therapy.Dual-targeted therapy combining tumor cell targeting and organelle targeting is a...The accurate delivery of nanoparticles and organic small molecule drugs remains a serious challenge in nanoparticle-based tumor therapy.Dual-targeted therapy combining tumor cell targeting and organelle targeting is an effective solution.Here,an anticancer nanoformulation accurate delivery system was prepared using hyaluronic acid (HA) targeting CD44 receptors on the surface of tumor cells and IR780iodine (IR780) targeting mitochondrial for delivery.The system is based on an ultra-small Janus structured inorganic sensitizer TiO_(2-x)@NaGdF_(4) nanoparticles (TN NPs) prepared by one-step pyrolysis,further loaded with organic small molecule acoustic sensitizer IR780 and mitochondrial hexokinase Ⅱ inhibitor lonidamine (LND),followed by encapsulation of HA.Ultra-small size nanoparticles exhibit strong tissue penetration,tumor inhibition and in vivo metabolism.Under ultrasound radiation,TN NPs and IR780could produce a synergistic effect,effectively increased the efficiency of reactive oxygen species (ROS)production.Meanwhile,the released IR780 could smoothly target the mitochondria,and the ROS produced by IR780 can destroy the mitochondrial structure and disrupt the mitochondrial respiration.LND could inhibit the energy metabolism of tumor cells by reducing the activity of hexokinase Ⅱ (HK Ⅱ),which further accelerates the process of apoptosis.Furthermore,since the Janus structure allows the integration of multifunctional components into a single system,TN NPs can not only serve as an acoustic sensitizer to generate ROS,but the Gd element contained can also act as the nuclear magnetic resonance (MR)imaging contrast agent,suggesting that the nanoformulation can enable imaging-guided diagnosis and therapy.In conclusion,a new scheme to enhance sonodynamic therapy (SDT) and chemotherapy synergistically is proposed here based on ultra-small dual-targeted nanoformulation with Janus structure in the ultrasound radiation environment.展开更多
A balanced consumption of various types of food items plays a crucial role in students’physical and intellectual development,providing the foundation for their lifelong health(1).In recent years,the living standards ...A balanced consumption of various types of food items plays a crucial role in students’physical and intellectual development,providing the foundation for their lifelong health(1).In recent years,the living standards in China have improved,leading to a steady improvement in the intake of various foods among Chinese students(2).However,uneven socioeconomic development and differing natural environments may lead to disparities in food consumption between rural and urban students(3).The prevalence of malnutrition among rural students has decreased but remains higher than among urban students(4).Furthermore,consumption of various healthy foods increased during the coronavirus disease 2019(COVID-19)pandemic as a means to boost immunity and promote health(5).展开更多
Two-dimensional code technology is widely used in all walks of life due to its high reliability,large information capacity and relative security of infor-mation.As the carrier of data transmission,two-dimensional code...Two-dimensional code technology is widely used in all walks of life due to its high reliability,large information capacity and relative security of infor-mation.As the carrier of data transmission,two-dimensional code has become a new form of nearfield communication,and mainly used for theflow of docu-ments.The rapid spread of smart devices with cameras has further broadened the use of two-dimensional code.The combination of smartphones and two-dimensional code eliminates the dependence on special physical isolation devices and reduces transmission costs.In this paper,a two-dimensional code transmission system based on side channel is designed,which transmits confidential informa-tion through the visual main channel of two-dimensional code and retransmits feedback information through the acoustic side channel.This paper verifies the impact of QR code capacity on data integrity and improvesfile transfer integrity.展开更多
Recently,differential privacy algorithms based on deep learning have become increasingly mature.Previous studies provide privacy mostly by adding differential privacy noise to the gradient,but it will reduce the accur...Recently,differential privacy algorithms based on deep learning have become increasingly mature.Previous studies provide privacy mostly by adding differential privacy noise to the gradient,but it will reduce the accuracy,and it is difficult to balance privacy and accuracy.In this paper,the DP-ASSGD algo-rithm is proposed to counterpoise privacy and accuracy.The convergence speed is improved,the number of optimized iterations is decreased,and the privacy loss is significantly reduced.On the other hand,by using the postprocessing immunity characteristics of the differential privacy model,the Laplace smoothing mecha-nism is added to make the training process more stable and the generalization ability stronger.The experiment uses the MNIST dataset,with the same privacy budget,and compared with the existing differential privacy algorithms,the accu-racy is improved by 1.8%on average.When achieving the same accuracy,the DP-ASSGD algorithm consumes less privacy budget.展开更多
The practical applications of crystalline porous materials toward industrial separations require shaping them into robust monoliths(e.g., foams). The current methods are often complicated, environmentally unfriendly, ...The practical applications of crystalline porous materials toward industrial separations require shaping them into robust monoliths(e.g., foams). The current methods are often complicated, environmentally unfriendly, and unscalable, significantly hampering their practical application. Herein, we report a scalable, facile “one-step thermomolding” method to fabricate a class of hierarchically olefin-linked covalent organic framework(COF) foams via melt polymerization. The obtained pure COF foams possess higher crystallinity and porosity than literature, good moldability, and processability, greatly benefiting their practical applications(e.g., efficient oil-water separation with 99% removal efficiency and >100 cycle reusability). Moreover, a COF exhibiting the smallest(0.58 nm) eclipsed stacking pore among all 2-dimensional COFs with neutral skeletons is first fabricated via this protocol, demonstrating good C2 H2 purification performance and recyclability, surpassing the current benchmark materials. We believe that this facile fabrication strategy can promote access to a broad diversity of new COF foams and enlighten further avenues for green routes to large-scale synthesis and usage of COFs.展开更多
Solid polymer electrolytes have demonstrated high promise to solve the safety problems caused by conventional liquid electrolytes in lithium ion batteries.However,the inherent flammability of most polymer electrolyte ...Solid polymer electrolytes have demonstrated high promise to solve the safety problems caused by conventional liquid electrolytes in lithium ion batteries.However,the inherent flammability of most polymer electrolyte materials remains unresolved,hence hindering their further industrial application.Addressing this challenge,we designed and constructed a thermal-responsive imide-linked covalent organic framework(COF)bearing ortho-positioned hydroxy groups as precursors,which can conduct a thermal rearrangement to transform into a highly crystalline and robust benzoxazole-linked COF upon heating.Benefiting from the release of carbon dioxide through thermal rearrangement reaction,this COF platform exhibited excellent flame retardant properties.By contrast,classic COFs(e.g.,boronate ester,imine,olefin,imide linked)were all flammable.Moreover,incorpo-rating polyethylene glycol and Li salt into the COF channels can produce solid polymer electrolytes with outstanding flame retardancy,high ionic conductivity(6.42×10^(-4) S cm^(-1))and a high lithium-ion transference number of 0.95.This thermal rearrangement strategy not only opens a new route for the fabrication of ultrastable COFs,but also provides promising perspectives to designing flame-retardant materials for energy-related applications.展开更多
文摘Great Wall Motor(GWM),a leading automotive manufacturer,places a strong emphasis on environmental sustainability and social responsibility.The company focuses on comprehensively evaluating and enhancing its supply chain to align with these objectives.This evaluation spans the entire product life cycle,encompassing design,manufacturing,packaging,distribution,usage,and recycling and disposal processes.Key areas of focus include optimizing raw material selection,improving product recyclability,reducing energy consumption and waste emissions,and minimizing carbon emissions during transportation.Through these endeavors,GWM not only enhances its environmental performance by reducing carbon emissions and resource consumption but also bolsters its brand image and competitiveness in the market.GWM’s dedication to environmental innovation and technological leadership serves as a driving force behind sustainable development and social responsibility within the industry.
文摘The Feixianguan formation in the Kaijiang-Liangping basin has been the focus of extensive research on multiple aspects. Based on field survey, core observation, laboratory analysis and seismic data interpretation, the sequence stratigraphy and sedimentary facies of the Kaijiang-Liangping area are studied. Four sequence boundaries and three maximum flooding surfaces of the Feixianguan formation are detected in this area. Three third-order sequences are identified as first sequence (SQ1), the second sequence (SQ2), and the third sequence (SQ3) in which SQ1 corresponds to the member 1 of the Feixianguan formation, SQ2 corresponds to the member 2, and SQ3 corresponds to the member 3 and member 4. Member 1, 2, 3 and 4 are lithologic sections divided by predecessors. On the basis of this sequence division and their sedimentary marks, the facies of the Feixianguan formation can be divided into open platform and evaporate platform categories. The open platform is composed of three subfacies identified as platform bank or basin marginal bank, interbank, and platform basin. Thus, a sedimentary evolution model is established. According to the sedimentary and seismic characteristics of the Kaijiang-Liangping area, we determine that two oolitic bank models, the aggradation model and the progradation model, are developed in this area. The aggradation model is developed in the Longgang region, which includes the basin marginal bank as a favorable exploring zone. The progradation model is developed in the Jiulongshan and Longhui areas, besides the basin marginal bank, the favorable exploration zones also include the oolitic bank developing areas of the inner basin.
文摘<strong>Objective: </strong>The quantum dots are the useful materials in microelectronics and biomedical research. However its toxicity has to be considered. We studied the effect of cell inhibition with ZnS core quantum dots and CdTe quantum dots modified with Thioglycolic acid or Cysteine functional group (TGA-CdTe, TGA-CdTe/ZnS, Cys-CdTe, Cys-CdTe/ZnS) on Caco-2 cell proliferation. <strong>Methods</strong>: We studied the effect of cell inhibition with ZnS core QDs and CdTe QDs modified with functional group on Caco-2 cell proliferation by MTT assay at 0, 12.5, 25, 50, 100 μg/ml and 6, 24, 48 h. <strong>Result:</strong> Our results showed that all QDs have inhibited cell proliferation and reached maximum 79.21%. The inhibition rate of Cys-modified QDs increased with the increase of concentration and reached maximum 66.72%. The inhibition rate of TGA-modified QDs increased with the increase of time. The ratios of Cys-modified to TGA-modified were less than 1 at all concentrations and three exposure times (P ≤ 0.01). The average ratios of Cys-CdTe/ZnS to Cys-CdTe reached 1.11 only for 48 h (P ≤ 0.05). The ratios of TGA-CdTe/ZnS to TGA-CdTe were closed to 1 at all concentrations and exposure times. <strong>Conclusion:</strong> The regularity of QDs modified with functional group is that inhibition of TGA-modified higher than Cys-modified. Inhibition exhibited dose-dependent for Cys-modified while exhibited time-dependent for TGA-modified. The regularity of CdTe-QDs with ZnS or not is that the inhibition of Cys-CdTe/ZnS was higher than Cys-CdTe while TGA-CdTe/ZnS and TGA-CdTe were consistent.
基金supported by the National Natural Science Foundation of China(61501176)University Nursing Program for Young Scholars with Creative Talents in Heilongjiang Province(UNPYSCT-2016017)
文摘The traditional super-resolution direction finding methods based on sparse recovery need to divide the estimation space into several discrete angle grids, which will bring the final result some error. To this problem, a novel method for wideband signals by sparse recovery in the frequency domain is proposed.The optimization functions are found and solved by the received data at every frequency, on this basis, the sparse support set is obtained, then the direction of arrival(DOA) is acquired by integrating the information of all frequency bins, and the initial signal can also be recovered. This method avoids the error caused by sparse recovery methods based on grid division, and the degree of freedom is also expanded by array transformation, especially it has a preferable performance under the circumstances of a small number of snapshots and a low signal to noise ratio(SNR).
基金supported by the National Natural Science Foundation of China(6150117661201399)+1 种基金the Education Department of Heilongjiang Province Science and Technology Research Projects(12541638)the Developing Key Laboratory of Sensing Technology and Systems in Cold Region of Heilongjiang Province and Ministry of Education,(Heilongjiang University),P.R.China(P201408)
文摘For the direction of arrival(DOA) estimation,traditional sparse reconstruction methods for wideband signals usually need many iteration times.For this problem,a new method for two-dimensional wideband signals based on block sparse reconstruction is proposed.First,a prolate spheroidal wave function(PSWF) is used to fit the wideband signals,then the block sparse reconstruction technology is employed for DOA estimation.The proposed method uses orthogonalization to choose the matching atoms,ensuring that the residual components correspond to the minimum absolute value.Meanwhile,the vectors obtained by iteration are back-disposed according to the corresponding atomic matching rules,so the extra atoms are abandoned in the course of iteration,and the residual components of current iteration are reduced.Thus the original sparse signals are reconstructed.The proposed method reduces iteration times comparing with the traditional reconstruction methods,and the estimation precision is better than the classical two-sided correlation transformation(TCT)algorithm when the snapshot is small or the signal-to-noise ratio(SNR) is low.
基金by the Application for Collaborative Research Project under International Joint Research Laboratory of Earthquake Engineering(TMGFXK-2015-002-2)Fundamental Research Funds for the Central University(22120180315,22120170521).
文摘Wood and wood-based composite materials have gained increasing attention in the sustainable building industry because of their renewability and environmental friendliness.Oriented oblique strand lumber(Eucalyptus Strand Wood,ESWood),which is manufactured from fast-growing small diameter eucalyptus wood(Eucalyptus urophylla×E.grandis),is introduced in this paper.Small clear specimen tests were conducted to determine the mechanical properties of ESWood material while full-scale component tests were performed to observe the structural performance of ESWood beams.A comparison of mechanical properties of ESWood with other wood/bamboo-based materials is then reported.From the results presented herein,it appears that the strength and stiffness properties of ESWood are affected by grain directionality and glued layers.However,it still has preferable mechanical properties as a building material,which is comparable or superior to those of other engineered wood/bamboo-based products(e.g.,Sitka spruce,LVL,OSL,Glulam,and Glubam).Furthermore,results from full-scale component tests show the stable mechanical performance of beams made by ESWood.This study makes a significant contribution to a potential utilization of fast-growing eucalyptus for general use in construction,and the presented mechanical tests results can serve as a fundamental data for more applications of ESWood in practical engineering.
文摘With the widespread deployment of biometric recognition,personal data security and privacy are attracted more and more attentions.A crucial privacy issue is how to ensure the security of user template.This paper proposes a novel template protection algorithm for face recognition based on chaotic map.Each face template is corresponding to different chaotic sequence produced by system master key and user identification number.The order of chaotic sequence controls the substitution index of face template.Experiment results on facial FERET database show that our algorithm can significantly improve the recognition performance and ensure the security of face template.
文摘This paper brings forward a method of experimental teaching reform of universities and colleges,which establishes an interactive simulation experiment platform with MATLAB simulation software.The platform uses visual man-machine interface,which avoids a lot of programming and debugging work,and improves students’learning enthusiasm.Simultaneously,it implements remote simulation based on JAVA under web environment,which is convenient for network teaching,and improves flexibility and practicability of the simulation experiment platform.
文摘As the rapid development of information technology represented by mobile internet,internet of things,social computing,society has entered the age of big data,information technology and education teaching are also merged gradually,microlecture as a new application of education and teaching took the wide attention of scholars.This paper analyzes the disadvantages of PAD class and takes microlecture to apply to two stage of PAD class.
基金the financial support from the National Natural Science Foundation of China(51821002)the Collaborative Innovation Center of Suzhou Nano Science&Technology+2 种基金the Deutsche Forschungsgemeinschaft(SFB 858 projects B3,the German-Chinese Transregional Collaborative Research Centre TRR 61/PAK 943)the Europ?ischer Fonds für regionale Entwicklung(EFRE)innovation laboratory for high performance materials(JLU)the National Key Research and Development Program of China(2018YFE0200700)。
基金financially supported by the National Natural Science Foundation of China (Nos. 52250077, 52272156, 51872263 and 52202175)Taishan Scholars Project (No. ts20190911)+1 种基金Shandong Natural Science Foundation (No. ZR2020ZD36)Guangdong Basic and Applied Basic Research Foundation (No. 2022A1515010461)。
文摘The accurate delivery of nanoparticles and organic small molecule drugs remains a serious challenge in nanoparticle-based tumor therapy.Dual-targeted therapy combining tumor cell targeting and organelle targeting is an effective solution.Here,an anticancer nanoformulation accurate delivery system was prepared using hyaluronic acid (HA) targeting CD44 receptors on the surface of tumor cells and IR780iodine (IR780) targeting mitochondrial for delivery.The system is based on an ultra-small Janus structured inorganic sensitizer TiO_(2-x)@NaGdF_(4) nanoparticles (TN NPs) prepared by one-step pyrolysis,further loaded with organic small molecule acoustic sensitizer IR780 and mitochondrial hexokinase Ⅱ inhibitor lonidamine (LND),followed by encapsulation of HA.Ultra-small size nanoparticles exhibit strong tissue penetration,tumor inhibition and in vivo metabolism.Under ultrasound radiation,TN NPs and IR780could produce a synergistic effect,effectively increased the efficiency of reactive oxygen species (ROS)production.Meanwhile,the released IR780 could smoothly target the mitochondria,and the ROS produced by IR780 can destroy the mitochondrial structure and disrupt the mitochondrial respiration.LND could inhibit the energy metabolism of tumor cells by reducing the activity of hexokinase Ⅱ (HK Ⅱ),which further accelerates the process of apoptosis.Furthermore,since the Janus structure allows the integration of multifunctional components into a single system,TN NPs can not only serve as an acoustic sensitizer to generate ROS,but the Gd element contained can also act as the nuclear magnetic resonance (MR)imaging contrast agent,suggesting that the nanoformulation can enable imaging-guided diagnosis and therapy.In conclusion,a new scheme to enhance sonodynamic therapy (SDT) and chemotherapy synergistically is proposed here based on ultra-small dual-targeted nanoformulation with Janus structure in the ultrasound radiation environment.
文摘A balanced consumption of various types of food items plays a crucial role in students’physical and intellectual development,providing the foundation for their lifelong health(1).In recent years,the living standards in China have improved,leading to a steady improvement in the intake of various foods among Chinese students(2).However,uneven socioeconomic development and differing natural environments may lead to disparities in food consumption between rural and urban students(3).The prevalence of malnutrition among rural students has decreased but remains higher than among urban students(4).Furthermore,consumption of various healthy foods increased during the coronavirus disease 2019(COVID-19)pandemic as a means to boost immunity and promote health(5).
文摘Two-dimensional code technology is widely used in all walks of life due to its high reliability,large information capacity and relative security of infor-mation.As the carrier of data transmission,two-dimensional code has become a new form of nearfield communication,and mainly used for theflow of docu-ments.The rapid spread of smart devices with cameras has further broadened the use of two-dimensional code.The combination of smartphones and two-dimensional code eliminates the dependence on special physical isolation devices and reduces transmission costs.In this paper,a two-dimensional code transmission system based on side channel is designed,which transmits confidential informa-tion through the visual main channel of two-dimensional code and retransmits feedback information through the acoustic side channel.This paper verifies the impact of QR code capacity on data integrity and improvesfile transfer integrity.
文摘Recently,differential privacy algorithms based on deep learning have become increasingly mature.Previous studies provide privacy mostly by adding differential privacy noise to the gradient,but it will reduce the accuracy,and it is difficult to balance privacy and accuracy.In this paper,the DP-ASSGD algo-rithm is proposed to counterpoise privacy and accuracy.The convergence speed is improved,the number of optimized iterations is decreased,and the privacy loss is significantly reduced.On the other hand,by using the postprocessing immunity characteristics of the differential privacy model,the Laplace smoothing mecha-nism is added to make the training process more stable and the generalization ability stronger.The experiment uses the MNIST dataset,with the same privacy budget,and compared with the existing differential privacy algorithms,the accu-racy is improved by 1.8%on average.When achieving the same accuracy,the DP-ASSGD algorithm consumes less privacy budget.
基金supported by the National Natural Science Foundation of China (22175099)111 Projects (B12015)Frontiers Science Center for New Organic Matter (63181206)。
文摘The practical applications of crystalline porous materials toward industrial separations require shaping them into robust monoliths(e.g., foams). The current methods are often complicated, environmentally unfriendly, and unscalable, significantly hampering their practical application. Herein, we report a scalable, facile “one-step thermomolding” method to fabricate a class of hierarchically olefin-linked covalent organic framework(COF) foams via melt polymerization. The obtained pure COF foams possess higher crystallinity and porosity than literature, good moldability, and processability, greatly benefiting their practical applications(e.g., efficient oil-water separation with 99% removal efficiency and >100 cycle reusability). Moreover, a COF exhibiting the smallest(0.58 nm) eclipsed stacking pore among all 2-dimensional COFs with neutral skeletons is first fabricated via this protocol, demonstrating good C2 H2 purification performance and recyclability, surpassing the current benchmark materials. We believe that this facile fabrication strategy can promote access to a broad diversity of new COF foams and enlighten further avenues for green routes to large-scale synthesis and usage of COFs.
基金supported by Tianjin Natural Science Foundation(20JCJQJC00170)National Natural Science Foundation of China(22001131 and 22175099)+2 种基金Frontiers Science Center for New Organic Matter of Nankai University(63181206)111 Project(B12015)Postdoctoral Science Foundation of China(2019M660974).
文摘Solid polymer electrolytes have demonstrated high promise to solve the safety problems caused by conventional liquid electrolytes in lithium ion batteries.However,the inherent flammability of most polymer electrolyte materials remains unresolved,hence hindering their further industrial application.Addressing this challenge,we designed and constructed a thermal-responsive imide-linked covalent organic framework(COF)bearing ortho-positioned hydroxy groups as precursors,which can conduct a thermal rearrangement to transform into a highly crystalline and robust benzoxazole-linked COF upon heating.Benefiting from the release of carbon dioxide through thermal rearrangement reaction,this COF platform exhibited excellent flame retardant properties.By contrast,classic COFs(e.g.,boronate ester,imine,olefin,imide linked)were all flammable.Moreover,incorpo-rating polyethylene glycol and Li salt into the COF channels can produce solid polymer electrolytes with outstanding flame retardancy,high ionic conductivity(6.42×10^(-4) S cm^(-1))and a high lithium-ion transference number of 0.95.This thermal rearrangement strategy not only opens a new route for the fabrication of ultrastable COFs,but also provides promising perspectives to designing flame-retardant materials for energy-related applications.