OBJECTIVE To investigate the differences between theclinicopathologic characteristics and prognostic factors in patientswith localized and infiltrative gastric cancer (GC).METHODS Patients with advanced GC, who were a...OBJECTIVE To investigate the differences between theclinicopathologic characteristics and prognostic factors in patientswith localized and infiltrative gastric cancer (GC).METHODS Patients with advanced GC, who were admittedto the Department of Surgical Oncology of the First AffiliatedHospital of China Medical University, Shenyang, during a periodof January 1980-January 2000, were divided into the localizedand infiltrative GC groups. A comparative analysis of theclinicopathologic data and prognosis in the patients enrolled in thestudy was carried out based on the different macroscopic types.RESULTS There were significant differences in the sex ratio,tumor location, histologic type, depth of invasion, lymph nodemetastasis, lymphovascular cancer embolus (LVCE), growthpattern, and degree of radical surgery between the 2 groups.However, there were no significant differences in age, tumorsize, and intravenous cancer embolus between the 2 groups.The prognosis of the infiltrative GC group was poor. There weresignificant differences in the prognosis of the patients betweenthe 2 groups when tumor infiltration was within the muscularlayer or subserosa, yet the differences disappeared once the tumorinfiltration was beyond the serosal layer. The prognosis of thepatients with localized GC was closely related to tumor locationand lymph node metastasis. The prognostic factors of the patientsin the infiltrative GC group included lymph node metastasis,depth of invasion, and tumor size.CONCLUSION There are significant differences in theclinicopathologic characteristics and prognosis between the 2groups. Based on the biological characteristics of the tumors,individualized therapeutic plans will help to improve thetreatment outcome.展开更多
文摘OBJECTIVE To investigate the differences between theclinicopathologic characteristics and prognostic factors in patientswith localized and infiltrative gastric cancer (GC).METHODS Patients with advanced GC, who were admittedto the Department of Surgical Oncology of the First AffiliatedHospital of China Medical University, Shenyang, during a periodof January 1980-January 2000, were divided into the localizedand infiltrative GC groups. A comparative analysis of theclinicopathologic data and prognosis in the patients enrolled in thestudy was carried out based on the different macroscopic types.RESULTS There were significant differences in the sex ratio,tumor location, histologic type, depth of invasion, lymph nodemetastasis, lymphovascular cancer embolus (LVCE), growthpattern, and degree of radical surgery between the 2 groups.However, there were no significant differences in age, tumorsize, and intravenous cancer embolus between the 2 groups.The prognosis of the infiltrative GC group was poor. There weresignificant differences in the prognosis of the patients betweenthe 2 groups when tumor infiltration was within the muscularlayer or subserosa, yet the differences disappeared once the tumorinfiltration was beyond the serosal layer. The prognosis of thepatients with localized GC was closely related to tumor locationand lymph node metastasis. The prognostic factors of the patientsin the infiltrative GC group included lymph node metastasis,depth of invasion, and tumor size.CONCLUSION There are significant differences in theclinicopathologic characteristics and prognosis between the 2groups. Based on the biological characteristics of the tumors,individualized therapeutic plans will help to improve thetreatment outcome.
