Nitrogen Metabolism and Curing Characteristics of Flue-cured Tobacco Variety NC71

[Objectives]To explore the growth characteristics,nitrogen metabolism and curing characteristics of the new variety NC71 in strongly aromatic tobacco leaves production area.[Methods]With Yunyan 87 as the control and NC71 as the experimental material,the experiment was carried out in Nanyang tobacco area for two consecutive years to study the growth characteristics of tobacco plants,the activity of key enzymes in nitrogen metabolism,the content of secondary metabolites,and the differences of tobacco-related water content,PPO enzyme activity and total phenol content.[Results]NC71 plants had lower height,better appearance quality and lower nicotine,total sugar and chlorine content.NC71 high nitrogen treatment and Yunyan 87 medium nitrogen treatment had similar key enzyme activity of nitrogen metabolism,content of secondary metabolites;Yunyan 87 and NC71 were easy to cure and resistant to curing.[Conclusions]This study provides a reference for measuring the appropriate nitrogen application rate and optimizing the curing process from the activities of the key enzymes NR and GS in nitrogen metabolism at the mature stage of the variety.

FEW-NNN: A Fuzzy Entropy Weighted Natural Nearest Neighbor Method for Flow-Based Network Traffic Attack Detection

Attacks such as APT usually hide communication data in massive legitimate network traffic, and mining structurally complex and latent relationships among flow-based network traffic to detect attacks has become the focus of many initiatives. Effectively analyzing massive network security data with high dimensions for suspicious flow diagnosis is a huge challenge. In addition, the uneven distribution of network traffic does not fully reflect the differences of class sample features, resulting in the low accuracy of attack detection. To solve these problems, a novel approach called the fuzzy entropy weighted natural nearest neighbor(FEW-NNN) method is proposed to enhance the accuracy and efficiency of flowbased network traffic attack detection. First, the FEW-NNN method uses the Fisher score and deep graph feature learning algorithm to remove unimportant features and reduce the data dimension. Then, according to the proposed natural nearest neighbor searching algorithm(NNN_Searching), the density of data points, each class center and the smallest enclosing sphere radius are determined correspondingly. Finally, a fuzzy entropy weighted KNN classification method based on affinity is proposed, which mainly includes the following three steps: 1、 the feature weights of samples are calculated based on fuzzy entropy values, 2、 the fuzzy memberships of samples are determined based on affinity among samples, and 3、 K-neighbors are selected according to the class-conditional weighted Euclidean distance, the fuzzy membership value of the testing sample is calculated based on the membership of k-neighbors, and then all testing samples are classified according to the fuzzy membership value of the samples belonging to each class;that is, the attack type is determined. The method has been applied to the problem of attack detection and validated based on the famous KDD99 and CICIDS-2017 datasets. From the experimental results shown in this paper, it is observed that the FEW-NNN method improves the accuracy and efficiency of flow-based network traffic attack detection.

Nuclear entry of active caspase-3 is facilitated by its p3-recognition-based specific cleavage activity

作为一个批评 apoptosis 刽子手， caspase-3 变得激活然后进入原子核施加它的功能。然而，活跃 caspase-3 的这个原子条目的分子的机制仍然是未知的。在这研究，我们表明 caspase-3 怀有 crm-1-independent 在它的小子单元的原子出口信号(NES ) 。把 reverse-caspase-3 用作学习模型，我们发现在 caspase-3 的 NES 的功能没被 conformational 变化在导致的 caspase-3 激活期间扰乱。破坏劈开活动或 p3 识别地点的变化在活跃 caspase-3 的原子入口导致了一个缺点。我们提供活跃 caspase-3 的调停 p3 的特定的劈开活动废除了 NES 的功能的证据。在结论，我们的结果证明在 caspase-3 激活期间， NES 是组成地在场的。调停 p3 的特定的劈开活动在 caspase-3 废除 NES 功能，因此便于活跃 caspase-3 的原子入口。

An addition of medium-dose ATG to conditioning regimens favours the long-term survival of patients with allogeneic hematopoietic stem cell transplantation

Long-term survival of 116 leukemia/MDS patients received allo-SCT conditioned by a regimen with ATG-F or without ATG-F was analysed, together with the impact of ATG-F on the long-term survival, GVHD and disease relapse. Seventy patients received an ATG-F containing conditioning regimen FBCA, and 46 patients received a non-ATG-F FBC regimen. The FBCA regimen was associated with a 5-year survival of 65.4% in the complete HLA-matched group and 39.3% in the HLA-mismatched group. The difference between the two groups was significant (P = 0.012). For the FBC conditioning regimen, the 5-year overall survival of HLA-matched patients and the HLA-mismatched patients was 34.2% and 24.2% respectively (P = 0.216). The incidence of cGVHD was 32.9% and 83.6% in the FBCA and FBC condition regimen group respectively. Only 2.9% of the cases showed extensive cGVHD in the FBCA group while it was 69.4% in the FBC group (P = 0.00). Multivariate analysis indicated that relapse was related to the disease status and HLA typing, but unrelated to the conditioning regimens whether or not ATG-F was used (HR 0.54, P = 0.109). We conclude that the addition of ATG-F to conditioning regimen favours the longterm survival of allo-SCT.

Changing Characteristics on Dust Storm in Jiangsu

Based on observation data of dust storm for the years 1960-2006 from weather stations across Jiangsu, this essay provides a statistical analysis on the characteristics and trends, including the timeframes and regions of the incidences of four weather phenomena: sandstorm, blowing sand, floating dust and haze in an effort to better understand the trend of dust storm changes in Jiangsu Province, China. The result indicates that, on average, the incidences of sandstorm, indi- cated with the total number of days in a year in Jiangsu is low and on a declining trend. With the improvement of the environment, no sandstorm has been observed for many years. In general, those of blowing sand and floating dust have been reducing, and showing a significant improvement during the recent years. What should be noted, however, is the accelerated increase in haze incidences, particularly, in Southern Jiangsu.

A Compact UWB MIMO Antenna for Portable Applications

A novel compact multiple-input-multiple-output (MIMO) antenna for portable ul-trawideband (UWB) applications is presented. This antenna consists of two modified planar-monopole antenna elements with coplanar waveguides-fed printed on one side of the substrate. To enhance isolation and increase impedance bandwidth, a tree like stubs is placed on the ground plane at the 45°axis. The measured results show that the MIMO antenna operates from 2.3 GHz to 13 GHz, covering WLAN, WiMAX, and UWB. The low mutual coupling and low envelope correlation coefficient of less than 0.2 across the whole frequency band proved that this antenna was suitable for MIMO/diversity systems. Also, good performance of radiation patterns and the antenna’s compact size make it a good candidate for portable devices.

Prediction of Suitable Harvest Time in Aquaculture

A model is provided to predict the prawn’s harvest in aquaculture through analytical research in agrometeorology, mathematical statistics, synoptic meteorology and et al. It is found out that the Benefit Analysis of the Best Harvest is one of the most ideal ways. The models for the breeding objects, climate prediction and analysis of market quotation should be set up and perfected continuously. Only when the dynamic numerical simulation of the growth is accurate and the short-term weather forecast and the market quotation are reliable, will the suitable harvest time be predicted precisely. We used to write this paper with the foundation on ideologies.

Gypenosides ameliorate morphine-induced immunosuppression with an increased proportion of thymic T lymphocyte subsets and are involved in the regulation of the cAMP-CREM/CREB-IL-2 pathway

Opioid abuse can suppress the lymphatic system function,and produce severe immunosuppression that poses a significant risk of opportunistic infections such as methicillinresistant Staphylococcus aureus(MRSA)pneumonia.^(1,2)Gypenosides(Gps)are the most important immunomodulator components in the Chinese herbal medicine Gynostemma pentaphyllum.

Effect of sintering temperature in argon atmosphere on microstructure and properties of 3D printed alumina ceramic cores

Alumina ceramics with different sintering temperatures in argon atmosphere were obtained using stereolithography-based 3D printing.The effects of sintering temperature on microstructure and physical and mechanical properties were investigated.The results show that the average particle size,shrinkage,bulk density,crystallite size,flexural strength,Vickers hardness,and nanoindentation hardness increased with the increase in sintering temperature,whereas the open porosity decreased with increasing sintering temperature.No change was observed in phase composition,chemical bond,atomic ratio,and surface roughness.For the sintered samples,the shrinkage in Z direction is much greater than that in X or Y direction.The optimum sintering temperature in argon atmosphere is 1350℃with a shrinkage of 3.0%,3.2%,and 5.5%in X,Y,and Z directions,respectively,flexural strength of 26.7 MPa,Vickers hardness of 198.5 HV,nanoindentation hardness of 33.1 GPa,bulk density of 2.5 g/cm^3,and open porosity of 33.8%.The optimum sintering temperature was 70℃higher than that sintering in air atmosphere when achieved the similar properties.

Influence of Sintering Temperature on Microstructure and Mechanical Properties of Al2O3 Ceramic via 3D Stereolithography

In this work,aluminum oxide(Al2O3) ceramic samples were fabricated by 3D stereolithography printing.Printing process was followed by debinding and sintering.In addition,the effect of sintering temperature on micro structure and properties was investigated.Flexure strength was observed to increase with increasing sintering temperature due to fewer pores,fewer defects and stronger grain boundary bonding of samples at higher sintering temperatures.Maximum flexure strength of 138.5 MPa was obtained when sintering temperature was 150℃.Furthermore,the shrinkage along length direction decreased with the decreasing sintering temperature until reaching minimum value of 1.02% after sintering at 1200℃.After sintering at 1280℃,flexure strength was 24.0 MPa and the shrinkage along length direction was 2.1%,which meets demands of ceramic core.

Efficient Algorithm for the k-Means Problem with Must-Link and Cannot-Link Constraints

Constrained clustering,such as k-means with instance-level Must-Link(ML)and Cannot-Link(CL)auxiliary information as the constraints,has been extensively studied recently,due to its broad applications in data science and AI.Despite some heuristic approaches,there has not been any algorithm providing a non-trivial approximation ratio to the constrained k-means problem.To address this issue,we propose an algorithm with a provable approximation ratio of O(logk)when only ML constraints are considered.We also empirically evaluate the performance of our algorithm on real-world datasets having artificial ML and disjoint CL constraints.The experimental results show that our algorithm outperforms the existing greedy-based heuristic methods in clustering accuracy.

Optimal Expansion Planning Model for Integrated Energy System Considering Integrated Demand Response and Bidirectional Energy Exchange

The challenges of energy shortage and environmen-tal protection motivate people to take various measures to use energy wisely,and integrated energy systems are such a measure to tackle this challenge.In this paper,an optimal expansion planning model for an integrated energy system consisting of power grid,gas network and multiple energy hubs is proposed,where the planning objective is to minimize operational fuel cost and capital investment cost covering carbon capture equipment and energy hubs among others.To demonstrate the advantage of the proposed planning model,six case studies are investigated,and 13.47%annual cost savings can be achieved compared with the baseline planning scenario,which does not consider bidirectional energy exchange and integrated demand response program.Index Terms-Bidirectional energy exchange,energy hubs,integrated energy system,integrated demand response.

Additive Manufacturing of Liquid-Cooled Ceramic Heat Sinks:An Experimental and Numerical Study

With recent advances in power electronic packaging technologies,liquid-cooled ceramic heat sinks have been considered as a promising solution for further improving the performance of power electronic devices.In this study,several aluminum oxide heat sinks were fabricated and tested using the digital light processing-based ad-ditive manufacturing method,to verify their practical performance.The results showed that the complex cooling structures inside the heat sinks can be completely formed and exhibited high surface quality.The experimental thermal and hydraulic performances of the heat sinks were consistent with the numerically modeled predictions.Furthermore,by exploiting the advantages of additive manufacturing,a direct manifold microchannel(MMC)configuration was designed to reduce the vertical flow of the traditional MMC configuration and achieve an im-proved cooling efficiency.At a constant volumetric flow rate of 1 L/min,the direct MMC configuration achieved a 19.8%reduction in pressure drop and an 11.8%reduction in thermal resistance,as well as a more uniform temperature distribution.

Cybersecurity Named Entity Recognition Using Bidirectional Long Short-Term Memory with Conditional Random Fields

Network texts have become important carriers of cybersecurity information on the Internet.These texts include the latest security events such as vulnerability exploitations,attack discoveries,advanced persistent threats,and so on.Extracting cybersecurity entities from these unstructured texts is a critical and fundamental task in many cybersecurity applications.However,most Named Entity Recognition(NER)models are suitable only for general fields,and there has been little research focusing on cybersecurity entity extraction in the security domain.To this end,in this paper,we propose a novel cybersecurity entity identification model based on Bidirectional Long Short-Term Memory with Conditional Random Fields(Bi-LSTM with CRF)to extract security-related concepts and entities from unstructured text.This model,which we have named XBi LSTM-CRF,consists of a word-embedding layer,a bidirectional LSTM layer,and a CRF layer,and concatenates X input with bidirectional LSTM output.Via extensive experiments on an open-source dataset containing an office security bulletin,security blogs,and the Common Vulnerabilities and Exposures list,we demonstrate that XBi LSTM-CRF achieves better cybersecurity entity extraction than state-of-the-art models.

New inverter topology for ground current suppression in transformerless photovoltaic system application

An interesting inverter topology is proposed in this paper.It is similar to the typical three-phase full bridge inverter from the topology point of view,but smartly designed for the ground current reduction in single-phase photovoltaic(PV)inverter applications.Theoretical analysis is conducted to clarify the operation mechanism of the proposed topology.Performance evaluation is carried out to verify the effectiveness of the proposed topology for the ground current suppression.

Balancing flexural strength and porosity in DLP-3D printing Al_(2)O_(3)cores for hollow turbine blades

High porosity and high strength are usually mutually exclusive in the preparation of ceramic materials.However,high porosity and flexural strength are required for the preparation of complex ceramic cores for hollow turbine blades.In this study,Al_(2)O_(3)cores with high porosity and high flexural strength were successfully prepared using digital light processing(DLP)3 D printing technology.The influence of sintering temperature on the microstructure,pore evolution,and flexural strength of the cores were investigated.With an increase in the sintering temperature,the porosity of the ceramic cores first increased and then decreased,reaching a maximum value of 35%at 1400℃.The flexural strength increased with the increase in sintering temperature,but at 1400℃the incremental enhancement of flexural strength was greatest.Combined with the core service requirements and core performance,this study selected 1400℃(open porosity of 35.1%and flexural strength of 20.3 MPa)as the optimal sintering temperature for the DLP-3 D printed Al_(2)O_(3)core.

Specific degradation of keratin in Xenopus laevis egg extracts undergoing apoptosis

Cytochrome c activates apoptosis specific protease XCPP32 when being added to Xenopus laevis egg extracts, and induces apoptosis in this cell-free system. During apoptosis, cyto-skeleton proteins in egg extracts are degraded. Western blot assay indicates that 42-ku acidic keratin in egg extracts has been degraded by XCPP32. The degradation of 42-ku keratin may be crucial in apoptosis.

Identification of inhibitor of apoptosis specific DNase in Xenopus egg extract

When added with cytochrome c, Xenopus laevis egg extract XS-150 can induce exogenous nuclei undergoing apoptosis. Apoptosis specific DNase XAD was activated during this process, and cut chromatin between nucleosome, leading to DNA Ladder in electrophoresis. Our results showed that an inhibitor of XAD, IXAD, exists abundantly in normal egg extract, its molecular weight is about 40 ku. Normally, IXAD exists either in the form of dimmer or in complex with XAD. It was degraded during apoptosis, releasing active XAD. The results of Western assay and cross-inhibition showed that IXAD was likely homologous to DFF45 in structure and function. At the same time, these results also indicated that the pathway in apoptosis was conserved in evolution.

Rapid senescence induced by overexpression of p53 in NIH3T3 cells

An NIH3T3 cell line which overexpresses temperature-sensitive p53Val135 was constructed by introduction of p53Val135 gene. It exhibited rapidly characteristic morphological and biochemical alterations related to repli-cative senescence when being cultured in 32℃. We suggested that the overexpression of p53 activated probably the onset of senescence in NIH3T3 cells, which induced a rapid cellular senescence.