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Private banking development in China under two organizational structures:Economic analysis from an organizational innovation perspective
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作者 He Liu Yun Bai +2 位作者 zhiguang huang Han Qiao Shouyang Wang 《Financial Innovation》 2023年第1期2779-2801,共23页
This paper investigates optimal decisions for private banking development in China under two innovative organizational structures—the big retail mode(BRM)and the independent development mode(IDM).Under the BRM,the re... This paper investigates optimal decisions for private banking development in China under two innovative organizational structures—the big retail mode(BRM)and the independent development mode(IDM).Under the BRM,the retail and private banking divisions form a cooperative relationship wherein the former transfers highnet-worth customers to the latter.In addition,retail banking receives a share of private banking revenues.We investigate the optimal revenue-sharing ratio between the two divisions and the optimal effort by private banking to serve transferred customers within the cooperative relationship.The analytical results show that as the private banking division becomes more developed,the optimal revenue-sharing ratio decreases,and the private banking division’s optimal effort to serve transferred customers decreases because it puts more effort into acquiring new customers.Under the IDM,the two divisions form a competitive relationship since they compete to acquire customers independently.We investigate customer acquisition efforts in this interdivisional competition.Optimal customer acquisition efforts by both divisions increase in potential assets and rates of return.This paper contributes to the literature by(1)analyzing financial innovation by private banks from an organizational perspective;(2)providing an economic analysis for private banking development in China. 展开更多
关键词 COMPETITION COOPERATION Innovative financial services Optimal banking decisions Organizational innovation Private banking
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MiR-133a-3p在膀胱癌中的表达及其分子机制研究
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作者 刘加林 翟高强 +3 位作者 黄志广 莫曾南 程继文 李生华 《生物工程前沿(中英文版)》 2022年第1期34-41,共8页
目的:利用生物信息学方法研究miR-133a-3p在膀胱癌组织中的表达和临床意义,并鉴定其靶基因和信号通路。方法:来自多个公共高通量数据库的514例膀胱癌组织和78例非癌组织样本用于评估miR-133a-3p的表达水平和临床意义。MiR-133a-3p的靶... 目的:利用生物信息学方法研究miR-133a-3p在膀胱癌组织中的表达和临床意义,并鉴定其靶基因和信号通路。方法:来自多个公共高通量数据库的514例膀胱癌组织和78例非癌组织样本用于评估miR-133a-3p的表达水平和临床意义。MiR-133a-3p的靶基因用于检测与膀胱癌进展相关的信号通路及其枢纽基因,并进一步验证枢纽基因与miR-133a-3p的相关性。结果:与非癌组织相比,miR-133a-3p在膀胱癌组织中表达显著下调(SMD=-1.604,p=0.015),且对膀胱癌具有鉴别意义(AUC=0.910,95%CI:0.880至0.930),miR-133a-3p高表达的膀胱癌患者预后相对较差(HR=1.383,p=0.030)。不同的患病年龄(t=2.414,p=0.0162)、疾病分期(T分期:t=2.488,p=0.0133;N分期:t=3.153,p=0.0017)、病理等级(t=2.067,p=0.0393)、肿瘤亚型(t=3.118,p=0.0048)的膀胱癌患者之间,其miR-133a-3p表达水平存在显著差异。富集分析结果表明miR-133a-3p的靶基因通过癌症、胞吞、Rap1等信号通路在膀胱癌中发挥影响。通过蛋白互作网络共筛选出9个枢纽基因(EGFR、CLTA、ARPC5、TFRC、NUDT21、FPR3、LAMC1、GNAI3、CAP1),其中CLTA、TFRC、NUDT21、CAP1与miR-133a-3p呈显著负相关。结论:miR-133a-3p在膀胱癌中表达下调且对膀胱癌具有良好的鉴别、预后价值,它可通过多种信号途径影响膀胱癌的进程。 展开更多
关键词 MiR-133a-3p 膀胱癌 差异表达 预后 富集分析 枢纽基因
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