Analysis on the Clinical Effect of Shenling Baizhu San Combined with Routine Treatment on Bacterial Pneumonia in Children

[Objectives]To explore the effect of Shenling Baizhu San combined with routine treatment on the clinical efficacy,gastrointestinal function protection,inflammatory response and immune function of children with bacterial pneumonia.[Methods]From July 2017 to January 2018,80 children with bacterial pneumonia were randomly selected and divided into observation group and control group with 40 cases in each group.The control group was treated with conventional Western medicine,while the observation group was treated with Shenling Baizhu San on the basis of conventional treatment,with a period of 10 d.Then,we compared the clinical efficacy,incidence of gastrointestinal symptoms,WBC,CRP,CD4+and CD8+levels between the two groups.[Results]The clinical efficacy of the observation group was better than that of the control group(P<0.05).After treatment,the levels of WBC and CRP in the two groups decreased,especially in the observation group(P<0.05).After treatment,the level of CD4+in both groups increased significantly,while the level of CD8+decreased significantly,and the level of CD4+in the observation group was significantly higher than that in the control group after treatment.The incidence of gastrointestinal symptoms in the observation group was significantly lower than that in the control group(P<0.01).[Conclusions]Shenling Baizhu San can obviously improve the clinical effect of bacterial pneumonia in children and has the protective effect of gastrointestinal tract,and its mechanism may be related to its anti-inflammatory and immunomodulatory effects.

Protective Effect of Shenlingbaizhu Powder on Peroxidation Injury and Inflammatory Response in Mice with Pneumonia

[Objectives]The study aims to explore the protective effect of Shenlingbaizhu powder on peroxidation injury and inflammatory response in mice with pneumonia.[Methods]60 NIH mice were randomly divided into the blank group,model group,control group,large dose group,medium dose group and small dose group of Shenlingbaizhu powder.The mice in the control group were given cefixime granules,while the mice in each group of Shenlingbaizhu powder were given corresponding concentrations of Shenlingbaizhu powder water decoction by gavage.After 7 d,the content of MAD,SOD and CRP in the mice were detected by ELISA,while the content of NO was detected by fluorescence,and lung index was also detected.[Results]The medium dose and large dose of Shenlingbaizhu powder can effectively reduce the concentration of MAD and improve the level of SOD in mice with pneumonia.The effect of the large dose of Shenlingbaizhu powder is more obvious than that of the control group.Moreover,the large dose of Shenlingbaizhu powder can effectively reduce the level of NO in mice with pneumonia.In addition,the medium dose and large dose of Shenlingbaizhu powder can reduce the lung index and CRP level of mice with pneumonia,and the results are statistically significant.[Conclusions]The medium dose and large dose of Shenlingbaizhu powder can effectively reduce the concentration of MAD and improve the level of SOD in mice with pneumonia.The effect of the large dose of Shenlingbaizhu powder is more obvious than that of the control group.Moreover,the large dose of Shenlingbaizhu powder can effectively reduce the level of NO in mice with pneumonia.In addition,the medium dose and large dose of Shenlingbaizhu powder can reduce the lung index and CRP level of mice with pneumonia,and the results are statistically significant.

Near-infrared light-driven Janus capsule motors： Fabrication, propulsion, and simulation

We report a fuel-free, near-infrared （NIR）-driven Janus microcapsule motor. The Janus microcapsule motors were fabricated by template-assisted polyelectrolyte layer-by-layer assembly, followed by spraying of a gold layer on one side. The NIR-powered Janus motors achieved high propulsion with a maximum speed of 42μm.s-1 in water. The propulsion mechanism of the Janus motor was attributed to the self-thermophoresis effect： The asymmetric distribution of the gold layer generated a local thermal gradient, which in turn generated thermophoretic force to propel the Janus motor. Such NIR-propelled Janus capsule motors can move efficiently in cell culture medium and have no obvious effects on the cell at the power of the NIR laser, indicating considerable promise for future biomedical applications.

Liquid Metal Swimming Nanorobots

CONSPECTUS:Room temperature liquid metal gallium-based materials have received tremendous attention owing to their potential promises in various aspects including bioengineering and smart medicine,flexible circuits and electronic skins,transformable activators and triboelectric nanogenerators,etc.Particularly,the usage of gallium-based liquid metals to construct humanoid robots to accomplish diverse dangerous missions leads to the considerable focus on the development of gallium-based flexible robots.Unlike conventional metal materials with rigid properties and responsible mainly for the backbone,room temperature gallium-based liquid metals could serve as a new generation of smart flexible materials for robotic devices with its advantages,such as low toxicity,high fluidity,and plasticity at the micro/nanometer sizes.With the expectation in biomedicine,such as targeted drug delivery,the past decade has led to the scaling down of the swimming robot to the micro-and nanoscales.Swimming nanorobots,which are defined as devices that can convert chemical energy in the surrounding environment and externally physical field into their own kinetic energy at the micro/nanoscale and achieve self-propulsion,have shown widespread potential in the field of in vivo applications.Despite the great promises,gallium-based liquid metal robots are primarily limited to the millimeter and subcentimeter scales.Moving toward clinical medical practices,however,these gallium-based liquid metal swimming robots are facing the biocompatible problem caused by their large sizes and propulsion approaches.Particularly,the manufacture,selfpropulsion,and navigation of nanoscale liquid metal swimming robots,ensuring the penetration though various tissues toward the disease area,is still challenging.Construction of gallium-based swimming nanorobots is of vital importance both for fundamental research,such as the dynamics of individual nanorobots and emergence of nanorobotic swarms,as well as for engineering and bioapplications,for instance,active target delivery.When applied as an in vivo surgical agent,the gallium-based liquid metal nanorobots will not only gather into the disease site at a higher targeting ratio but also behave in an emerged collective means that transform and infuse to destroy the lesion by photothermal and photodynamic therapy,and so on.Compared with the large-scale liquid metal robots,gallium-based swimming nanorobots offer the advantages in treatment of tumors with lower intensity,navigation with higher precision,and surgical therapies with minor invasion.