Wound complications are estimated to be affected in about 9% of TKA patients, which may increase the risk of deep periprosthetic infection and results in re-operation, joint fusion, or amputation. Here we have reporte...Wound complications are estimated to be affected in about 9% of TKA patients, which may increase the risk of deep periprosthetic infection and results in re-operation, joint fusion, or amputation. Here we have reported a female patient who suffered wound rupture due to early post-operation mobilization and weight-bearing. The wound dehiscence was successfully managed by applying recombinant basic fibroblast growth factor-2 and anti-infective treatment without removing prosthetic joint.展开更多
To the Editor:Osteoarthritis(OA)is a disease associated with high morbidity and disability.Obesity,typically measured as a body mass index(BMI)≥30 kg/m2,is a well-known risk factor for the onset of OA and its related...To the Editor:Osteoarthritis(OA)is a disease associated with high morbidity and disability.Obesity,typically measured as a body mass index(BMI)≥30 kg/m2,is a well-known risk factor for the onset of OA and its related complications.[1]Interestingly,these two diseases may have common underlying mechanisms which contribute to the pathogenesis,such as genetic changes,and these mechanisms have not yet been fully explored.Gene expression profiling is a powerful tool used to systematically identify the molecular features underlying genetic variations associated with complex multifactorial diseases such as OA.In addition,it has been shown the significance of gene expression in understanding the mechanisms in the pathogenesis of obesity and OA.[2]This study hypothesized that hub genes could explain the relationship between obesity and OA.Consequently,identifying that these genes are involved could provide insights into the detailed regulatory mechanisms of obesity on OA.展开更多
文摘Wound complications are estimated to be affected in about 9% of TKA patients, which may increase the risk of deep periprosthetic infection and results in re-operation, joint fusion, or amputation. Here we have reported a female patient who suffered wound rupture due to early post-operation mobilization and weight-bearing. The wound dehiscence was successfully managed by applying recombinant basic fibroblast growth factor-2 and anti-infective treatment without removing prosthetic joint.
基金This work was supported by grants from the National Natural Science Foundation of China(Nos.81771749 and 81901638)Harbin Technology Bureau Research Fund(No.2017RAQXJ196)Scientific Research Innovation Foundation of the First Affiliated Hospital of Harbin Medical University(No.2019B18)。
文摘To the Editor:Osteoarthritis(OA)is a disease associated with high morbidity and disability.Obesity,typically measured as a body mass index(BMI)≥30 kg/m2,is a well-known risk factor for the onset of OA and its related complications.[1]Interestingly,these two diseases may have common underlying mechanisms which contribute to the pathogenesis,such as genetic changes,and these mechanisms have not yet been fully explored.Gene expression profiling is a powerful tool used to systematically identify the molecular features underlying genetic variations associated with complex multifactorial diseases such as OA.In addition,it has been shown the significance of gene expression in understanding the mechanisms in the pathogenesis of obesity and OA.[2]This study hypothesized that hub genes could explain the relationship between obesity and OA.Consequently,identifying that these genes are involved could provide insights into the detailed regulatory mechanisms of obesity on OA.
