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Additive Manufacturing of Hydroxyapatite Bioceramic Scaffolds with Projection Based 3D Printing 被引量:2
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作者 Huifeng Shao zhiheng nian +5 位作者 Zhuoluo Jing Tao Zhang Jiahua Zhu Xiang Li Youping Gong Yong He 《Chinese Journal of Mechanical Engineering(Additive Manufacturing Frontiers)》 2022年第2期16-24,共9页
Hydroxyapatite(HA)bioceramics have garnered considerable attention owing to their applications in the field of bone repair and excellent biocompatibility.Compared to extrusion-based 3D printing,projection-based 3D pri... Hydroxyapatite(HA)bioceramics have garnered considerable attention owing to their applications in the field of bone repair and excellent biocompatibility.Compared to extrusion-based 3D printing,projection-based 3D print-ing(3DPP)can fabricate parts with complex geometry,high accuracy,and efficiency,which is very promising for bioceramic scaffolds.However,conventional 3DPP using a paste with low viscosity will cause severe shrinkage of the parts after sintering,which makes it unsuitable for bioceramic scaffolds,and a system investigation of the printing process remains insufficient.In this study,we proposed a 3DPP device suitable for bioceramic scaffolds and investigated the additive manufacturing of HA scaffolds.Ceramic paste properties and process parameters of curing,debinding,and sintering were initially examined.The mechanical properties,shrinkage,and biocompati-bility in vitro of the sintered samples were further investigated.The obtained results indicate that HA bioceramics with uniform morphology,complex structure,and high accuracy can be manufactured using the 3DPP equip-ment.HA scaffolds have the mechanical strength of human cancellous bone,while HA scaffolds cultured with osteoblast precursor cells possess strong biocompatibility and can promote osteoblast adhesion,proliferation,and differentiation.These results suggest a promising application of the 3DPP technique in the preparation of bioceramic scaffolds,and the HA scaffolds fabricated using the 3DPP technique exhibit promising potential in fulfilling a constructive role in the biomedical field of human bone regeneration repair. 展开更多
关键词 Projection based 3D printing HYDROXYAPATITE SCAFFOLD BIOSAFETY BIOCERAMIC
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