Cardiovascular disease(CVD)is a global health problem and is thought to be responsible for almost half of all deaths in the world.Nevertheless,currently available diagnostic methods for CVD are strongly depended on cl...Cardiovascular disease(CVD)is a global health problem and is thought to be responsible for almost half of all deaths in the world.Nevertheless,currently available diagnostic methods for CVD are strongly depended on clinical observation and monitoring,which commonly result in false diagnosis.Herein,an attractive strategy of a metal-organic framework(MOF)nanofilm-based laser desorption/ionization mass spectrometry(LDI-MS)was developed for enhancing serum metabolic profiling,which could provide precise diagnosis and molecular subtyping of CVD.The porous MOF nanofilm fabricated on indium-tin oxide(ITO)glass possessed enhanced ionization efficiency and size-exclusion effect,which endowed it as substrate with high sensitivity and selectivity for serum metabolites.Furthermore,the MOF nanofilm with uniform surface and high orientation provided high-quality and high-reproducibility serum metabolic profiles(SMPs)without any tedious pretreatment.Further analysis of extracted serum metabolic fingerprints could successfully distinguish patients with CVD from healthy controls and also differentiate two major subtypes of CVD.This work not only extends the application of MOF nanofilm as an attractive MS probe,but also provide an alternative way for precise diagnosis of CVD in molecular level.展开更多
As a kind of two-dimensional(2D)nanostructured materials,metal oxide nanosheets(MONS)are attractive and promising humidity sensing materials due to their considerable surface area,good charge carrier transportation,an...As a kind of two-dimensional(2D)nanostructured materials,metal oxide nanosheets(MONS)are attractive and promising humidity sensing materials due to their considerable surface area,good charge carrier transportation,and designable surface functional groups properties.Nevertheless,the ultra-thin MONS modified with active functional groups for humidity sensing are still rare.As a proof of concept,the atomically thin TiO_(2)nanosheets with high surface area and electron-donating amino groups are prepared by a structure-maintained post-ligand modification strategy.The fabricated TiO_(2)-based sensors demonstrate superior humidity sensing performance with high response,short response time,narrow hysteresis,and ultra-low theoretical limit of detection of about 15 ppm.Additionally,the possible mechanism is proposed from the AC complex impedance measurements and DC instantaneous reverse polarity experiments.This work provides a possible path for developing the high-performance 2D nanostructured metal oxides-based humidity materials through the surface chemical method.展开更多
基金supported by the National Natural Science Foundation of China(Nos.21974021 and 22036001)the Major Project of Science and Technology of Fujian Province(No.2020HZ06006)。
文摘Cardiovascular disease(CVD)is a global health problem and is thought to be responsible for almost half of all deaths in the world.Nevertheless,currently available diagnostic methods for CVD are strongly depended on clinical observation and monitoring,which commonly result in false diagnosis.Herein,an attractive strategy of a metal-organic framework(MOF)nanofilm-based laser desorption/ionization mass spectrometry(LDI-MS)was developed for enhancing serum metabolic profiling,which could provide precise diagnosis and molecular subtyping of CVD.The porous MOF nanofilm fabricated on indium-tin oxide(ITO)glass possessed enhanced ionization efficiency and size-exclusion effect,which endowed it as substrate with high sensitivity and selectivity for serum metabolites.Furthermore,the MOF nanofilm with uniform surface and high orientation provided high-quality and high-reproducibility serum metabolic profiles(SMPs)without any tedious pretreatment.Further analysis of extracted serum metabolic fingerprints could successfully distinguish patients with CVD from healthy controls and also differentiate two major subtypes of CVD.This work not only extends the application of MOF nanofilm as an attractive MS probe,but also provide an alternative way for precise diagnosis of CVD in molecular level.
基金supported by the National Natural Science Foundation of China(21905280,22171263,91961115,22175176 and 21975254)National Natural Science Foundation of Fujian(2021J02017 and 2020J01109)Youth Innovation Promotion Association CAS。
文摘As a kind of two-dimensional(2D)nanostructured materials,metal oxide nanosheets(MONS)are attractive and promising humidity sensing materials due to their considerable surface area,good charge carrier transportation,and designable surface functional groups properties.Nevertheless,the ultra-thin MONS modified with active functional groups for humidity sensing are still rare.As a proof of concept,the atomically thin TiO_(2)nanosheets with high surface area and electron-donating amino groups are prepared by a structure-maintained post-ligand modification strategy.The fabricated TiO_(2)-based sensors demonstrate superior humidity sensing performance with high response,short response time,narrow hysteresis,and ultra-low theoretical limit of detection of about 15 ppm.Additionally,the possible mechanism is proposed from the AC complex impedance measurements and DC instantaneous reverse polarity experiments.This work provides a possible path for developing the high-performance 2D nanostructured metal oxides-based humidity materials through the surface chemical method.
