Silver-copper electrocatalysts have demonstrated effectively catalytic performance in electroreduction CO_(2) toward CH_(4),yet a revealing insight into the reaction pathway and mechanism has remained elusive.Herein,w...Silver-copper electrocatalysts have demonstrated effectively catalytic performance in electroreduction CO_(2) toward CH_(4),yet a revealing insight into the reaction pathway and mechanism has remained elusive.Herein,we construct chemically bonded Ag-Cu_(2)O boundaries,in which the complete reduction of Cu_(2)O to Cu has been strongly impeded owing to the presence of surface Ag shell.The interfacial confinement effect helps to maintain Cu^(+)sites at the Ag-Cu_(2)O boundaries.Using in situ/operando spectroscopy and theoretical simulations,it is revealed that CO_(2) is enriched at the Ag-Cu_(2)O boundaries due to the enhanced physisorption and chemisorption to CO_(2),activating CO_(2) to form the stable intermediate^(*)CO.The boundaries between Ag shell and the Cu_(2)O mediate local^(*)CO coverage and promote^(*)CHO intermediate formation,consequently facilitating CO_(2)-to-CH_(4) conversion.This work not only reveals the structure-activity relationships but also offers insights into the reaction mechanism on Ag-Cu catalysts for efficient electrocatalytic CO_(2) reduction.展开更多
Lung cancer is the most common cancer worldwide. In the United States, it causes more cancer-related deaths than the next four causes (breast cancer, prostate cancer, colon cancer, and pancreatic cancer) of cancer-r...Lung cancer is the most common cancer worldwide. In the United States, it causes more cancer-related deaths than the next four causes (breast cancer, prostate cancer, colon cancer, and pancreatic cancer) of cancer-related mortality combined (1). About 30% of people have already progressed to stage III lung cancer and 40% to stage IV at the time they are diagnosed (2). Although chest X-ray and sputum cytology, when applied in health check-ups, can identify some relatively small tumors, they are not able to lower the overall mortality (3). More recently,展开更多
Effective osteogenesis remains a challenge in the treatment of bone defects.The emergence of artificial bone scaffolds provides an attractive solution.In this work,a new biomineralization strategy is proposed to facil...Effective osteogenesis remains a challenge in the treatment of bone defects.The emergence of artificial bone scaffolds provides an attractive solution.In this work,a new biomineralization strategy is proposed to facilitate osteogenesis through sustaining supply of nutrients including phosphorus(P),calcium(Ca),and silicon(Si).We developed black phosphorus(BP)-based,three-dimensional nanocomposite fibrous scaffolds via microfluidic technology to provide a wealth of essential ions for bone defect treatment.The fibrous scaffolds were fabricated from 3D poly(L-lactic acid)(PLLA)nanofibers(3D NFs),BP nanosheets,and hydroxyapatite(HA)-porous SiO2 nanoparticles.The 3D BP@HA NFs possess three advantages:i)stably connected pores allow the easy entrance of bone marrow-derived mesenchymal stem cells(BMSCs)into the interior of the 3D fibrous scaffolds for bone repair and osteogenesis;ii)plentiful nutrients in the NFs strongly improve osteogenic differentiation in the bone repair area;iii)the photothermal effect of fibrous scaffolds promotes the release of elements necessary for bone formation,thus achieving accelerated osteogenesis.Both in vitro and in vivo results demonstrated that the 3D BP@HA NFs,with the assistance of NIR laser,exhibited good performance in promoting bone regeneration.Furthermore,microfluidic technology makes it possible to obtain high-quality 3D BP@HA NFs with low costs,rapid processing,high throughput and mass production,greatly improving the prospects for clinical application.This is also the first BP-based bone scaffold platform that can self-supply Ca^(2+),which may be the blessedness for older patients with bone defects or patients with damaged bones as a result of calcium loss.展开更多
Bell nonlocality and Einstein-Podolsky-Rosen(EPR) steering are very important quantum correlations in composite quantum systems. Bell nonlocality of a bipartite state is observed in some local quantum measurements, wh...Bell nonlocality and Einstein-Podolsky-Rosen(EPR) steering are very important quantum correlations in composite quantum systems. Bell nonlocality of a bipartite state is observed in some local quantum measurements, while EPR steering was first observed by Schr o¨dinger in the context of famous EPR paradox. In this paper, we discuss the Bell nonlocality and EPR steering of bipartite states, including mathematical definitions and characterizations of these two quantum correlations, the convexity as well as the closedness of the sets of all Bell local states and all EPR unsteerable states, respectively. We also derive sufficient conditions for a state to be steerable; these conditions imply that Alice can steer Bob's state whenever Alice has two POV measurements such that the sets of Bob's normalized conditional states become two disjoint sets of pure states, or whenever she has one POV measurement such that Bob's normalized conditional states become a linearly independent set of pure states.展开更多
Celastrol,a Chinese herbal medicine,has exhibited anticancer activity in many types of cancer cells.However,the further clinical application of celastrol is restricted by its poor water solubility and serious side eff...Celastrol,a Chinese herbal medicine,has exhibited anticancer activity in many types of cancer cells.However,the further clinical application of celastrol is restricted by its poor water solubility and serious side effects.Furthermore,the apoptosis mechanism of tumor cells induced by celastrol has not been exhausted yet.In this study,we developed a reduction sensitive polymeric vector for tumor-targeted celastrol delivery.And our researches indicated that the celastrol could be delivered by reductionsensitive nanomedicine(RSNMs)with a controlled release strategy.Meanwhile,the cell uptake results indicated that excellent reduction-sensitive behavior of RSNMs could effectively accelerate celastrol into the human retinoblastoma(RB)cell.The cell cytotoxicity assay demonstrated that celastrol inhibited proliferation of human RB Y79 cells growth in a dose-dependent manner.Furthermore,the results of flow cytometry and terminal dUTP nick-end labeling(TUNEL)staining showed that celastrol induced apoptosis of the RB Y79 cells,and revealed a time-dependent increase in apoptosis induction of RB Y79 cells.The results of western blotting showed that celastrol induced the apoptosis of human RB Y79 cells involving the activation of caspase-3 and caspase-9.In conclusion,our results revealed that RSNMs may be utilized as a novel therapy for retinoblastoma.展开更多
Ultralow Pt-loading Au nanoparticles have been fabricated on the surface of reduced graphene oxide (RGO) by using underpotential deposition (UPD) monolayer redox replacement process. The Pt/Au/RGO modified electro...Ultralow Pt-loading Au nanoparticles have been fabricated on the surface of reduced graphene oxide (RGO) by using underpotential deposition (UPD) monolayer redox replacement process. The Pt/Au/RGO modified electrode exhibits an excellent electrocatalytic activity toward catechol and hydroquinone. Under the optimized condition, the separation of peak-to-peak between hydroquinone and catechol is 197 mV, which is wide enough to distinguish the isomers of benzenediol. Catechol is detected by the Pt/Au/RGO/GCE with a low detection limit in the presence of hydroquinone.展开更多
基金financially supported by the National Natural Science Foundation of China (21968020)the Natural Science Foundation of Inner Mongolia (2022MS02011 and 2023MS02014)+1 种基金the Science and Technology Projects of China Northern Rare Earth (BFXT-2022-D-0023)the Open Research Subject of Zhejiang Key Laboratory of Petrochemical Environmental Pollution Control (2021Z01)。
文摘Silver-copper electrocatalysts have demonstrated effectively catalytic performance in electroreduction CO_(2) toward CH_(4),yet a revealing insight into the reaction pathway and mechanism has remained elusive.Herein,we construct chemically bonded Ag-Cu_(2)O boundaries,in which the complete reduction of Cu_(2)O to Cu has been strongly impeded owing to the presence of surface Ag shell.The interfacial confinement effect helps to maintain Cu^(+)sites at the Ag-Cu_(2)O boundaries.Using in situ/operando spectroscopy and theoretical simulations,it is revealed that CO_(2) is enriched at the Ag-Cu_(2)O boundaries due to the enhanced physisorption and chemisorption to CO_(2),activating CO_(2) to form the stable intermediate^(*)CO.The boundaries between Ag shell and the Cu_(2)O mediate local^(*)CO coverage and promote^(*)CHO intermediate formation,consequently facilitating CO_(2)-to-CH_(4) conversion.This work not only reveals the structure-activity relationships but also offers insights into the reaction mechanism on Ag-Cu catalysts for efficient electrocatalytic CO_(2) reduction.
文摘Lung cancer is the most common cancer worldwide. In the United States, it causes more cancer-related deaths than the next four causes (breast cancer, prostate cancer, colon cancer, and pancreatic cancer) of cancer-related mortality combined (1). About 30% of people have already progressed to stage III lung cancer and 40% to stage IV at the time they are diagnosed (2). Although chest X-ray and sputum cytology, when applied in health check-ups, can identify some relatively small tumors, they are not able to lower the overall mortality (3). More recently,
基金the National Natural Science Foundation of China(U1904176,81600775,and 21504082to J.L.)+3 种基金Zhongyuan Thousand Talents Plan Project(to J.L.)Harvard Medical School/Brigham and Women’s Hospital Department of Anesthesiology-Basic Scientist Grant(2420 BPA075,to W.T.)Center for Nanomedicine Research Fund(2019A014810,to W.T.)Gillian Reny Stepping Strong Center for Trauma Innovation Breakthrough Innovator Award(113548,to W.T.).
文摘Effective osteogenesis remains a challenge in the treatment of bone defects.The emergence of artificial bone scaffolds provides an attractive solution.In this work,a new biomineralization strategy is proposed to facilitate osteogenesis through sustaining supply of nutrients including phosphorus(P),calcium(Ca),and silicon(Si).We developed black phosphorus(BP)-based,three-dimensional nanocomposite fibrous scaffolds via microfluidic technology to provide a wealth of essential ions for bone defect treatment.The fibrous scaffolds were fabricated from 3D poly(L-lactic acid)(PLLA)nanofibers(3D NFs),BP nanosheets,and hydroxyapatite(HA)-porous SiO2 nanoparticles.The 3D BP@HA NFs possess three advantages:i)stably connected pores allow the easy entrance of bone marrow-derived mesenchymal stem cells(BMSCs)into the interior of the 3D fibrous scaffolds for bone repair and osteogenesis;ii)plentiful nutrients in the NFs strongly improve osteogenic differentiation in the bone repair area;iii)the photothermal effect of fibrous scaffolds promotes the release of elements necessary for bone formation,thus achieving accelerated osteogenesis.Both in vitro and in vivo results demonstrated that the 3D BP@HA NFs,with the assistance of NIR laser,exhibited good performance in promoting bone regeneration.Furthermore,microfluidic technology makes it possible to obtain high-quality 3D BP@HA NFs with low costs,rapid processing,high throughput and mass production,greatly improving the prospects for clinical application.This is also the first BP-based bone scaffold platform that can self-supply Ca^(2+),which may be the blessedness for older patients with bone defects or patients with damaged bones as a result of calcium loss.
基金supported by the National Natural Science Foundation of China(Grant Nos.11871318,11771009,11571213,and 11601300)the Fundamental Research Funds for the Central Universities(Grant Nos.GK201703093,and GK201801011)
文摘Bell nonlocality and Einstein-Podolsky-Rosen(EPR) steering are very important quantum correlations in composite quantum systems. Bell nonlocality of a bipartite state is observed in some local quantum measurements, while EPR steering was first observed by Schr o¨dinger in the context of famous EPR paradox. In this paper, we discuss the Bell nonlocality and EPR steering of bipartite states, including mathematical definitions and characterizations of these two quantum correlations, the convexity as well as the closedness of the sets of all Bell local states and all EPR unsteerable states, respectively. We also derive sufficient conditions for a state to be steerable; these conditions imply that Alice can steer Bob's state whenever Alice has two POV measurements such that the sets of Bob's normalized conditional states become two disjoint sets of pure states, or whenever she has one POV measurement such that Bob's normalized conditional states become a linearly independent set of pure states.
基金supported by the National Natural Science Foundation of China(Nos.81600775,U1904176 and 21504082)the Science and Technology Program of Henan Province,China(No.202102310072)the Medical Science and Technology Program of Henan Province,China(Nos.2018020398 and SB201902026)。
文摘Celastrol,a Chinese herbal medicine,has exhibited anticancer activity in many types of cancer cells.However,the further clinical application of celastrol is restricted by its poor water solubility and serious side effects.Furthermore,the apoptosis mechanism of tumor cells induced by celastrol has not been exhausted yet.In this study,we developed a reduction sensitive polymeric vector for tumor-targeted celastrol delivery.And our researches indicated that the celastrol could be delivered by reductionsensitive nanomedicine(RSNMs)with a controlled release strategy.Meanwhile,the cell uptake results indicated that excellent reduction-sensitive behavior of RSNMs could effectively accelerate celastrol into the human retinoblastoma(RB)cell.The cell cytotoxicity assay demonstrated that celastrol inhibited proliferation of human RB Y79 cells growth in a dose-dependent manner.Furthermore,the results of flow cytometry and terminal dUTP nick-end labeling(TUNEL)staining showed that celastrol induced apoptosis of the RB Y79 cells,and revealed a time-dependent increase in apoptosis induction of RB Y79 cells.The results of western blotting showed that celastrol induced the apoptosis of human RB Y79 cells involving the activation of caspase-3 and caspase-9.In conclusion,our results revealed that RSNMs may be utilized as a novel therapy for retinoblastoma.
基金This work was financially supported by the National Natural Science Foundation of China (21271136), Natural Science Foundation of Anhui Province (1408085QB41, 1408085MB40), Natural Science Research Project of Education Department of Anhui Province (KJ2013A247, K J2016A888), Anhui Province Cultivate Outstanding Talent (2014SQR01), Opening Project of Anhui Key Laboratory of Spin Electron and Na- nomaterials (2013YKF20, 2014YKF52, 2011YKF03, 2014YKF35), the Program of Innovative Research Team of Anhui Provincial Education Department (Photoelectric information material new energy device), Innovative Research Team of Suzhou University (2013kytd02), Suzhou University Cultivate Outstanding Talent (No. 2014XQNRL005), and the College Students' Innovative Entrepreneurial Training Plan Program of Anhui Province (201510379133, 201410379067).
文摘Ultralow Pt-loading Au nanoparticles have been fabricated on the surface of reduced graphene oxide (RGO) by using underpotential deposition (UPD) monolayer redox replacement process. The Pt/Au/RGO modified electrode exhibits an excellent electrocatalytic activity toward catechol and hydroquinone. Under the optimized condition, the separation of peak-to-peak between hydroquinone and catechol is 197 mV, which is wide enough to distinguish the isomers of benzenediol. Catechol is detected by the Pt/Au/RGO/GCE with a low detection limit in the presence of hydroquinone.