Internet of things has been widely applied to industrial control, smart city and environmental protection, in these application scenarios, sensing node needs to make real-time response to the feedback control of the a...Internet of things has been widely applied to industrial control, smart city and environmental protection, in these application scenarios, sensing node needs to make real-time response to the feedback control of the application layer. Therefore, it is necessary to monitor whether or not awareness nodes are trusted in real time, but the existing mechanisms for trusted certification lack the real-time measurement and tracking of the sensing node. To solve the above problems,this paper proposes a dynamic metric based authentication mechanism for sensing nodes of Internet of things. Firstly, the dynamic trustworthiness measure of the sensing nodes is carried out by introducing the computational function such as the trust function, the trustworthiness risk assessment function, the feedback control function and the active function of the sensing node. The dynamic trustworthiness measure of sensing nodes from multiple dimensions can effectively describe the change of trusted value of sensing nodes. Then, on the basis of this, a trusted attestation based on node trusted measure is realized by using the revocable group signature mechanism of local verifier. The mechanism has anonymity, unforgeability and traceability, which is proved the security in the standard model. Simulationexperiments show that the proposed trusted attestation mechanism is flexible, practical and efficient and has better attack resistance. It can effectively guarantee the reliable data transmission of nodes and realize the dynamic tracking of node reliability, which has a lower impact on system performance.展开更多
Photobiomodulation using light in the red or near-infrared region is an innovative treatment strategy for a wide range of neurological and psychological conditions.Photobiomodulation can promote neurogenesis and elici...Photobiomodulation using light in the red or near-infrared region is an innovative treatment strategy for a wide range of neurological and psychological conditions.Photobiomodulation can promote neurogenesis and elicit anti-apoptotic,antiinflammatory and antioxidative responses.Its therapeutic effects have been demonstrated in studies on neurological diseases,peripheral nerve injuries,pain relief and wound healing.We conducted a comprehensive literature review of the application of photobiomodulation in patients with central nervous system diseases in February 2019.The NCBI PubMed database,EMBASE database,Cochrane Library and ScienceDirect database were searched.We reviewed 95 papers and analyzed.Photobiomodulation has wide applicability in the treatment of stroke,traumatic brain injury,Parkinson’s disease,Alzheimer’s disease,major depressive disorder,and other diseases.Our analysis provides preliminary evidence that PBM is an effective therapeutic tool for the treatment of central nervous system diseases.However,additional studies with adequate sample size are needed to optimize treatment parameters.展开更多
The distillation residues of middle-temperature coal tar(DRMCT) were separated into saturate, aromatic, resin and asphaltene fractions by using the combination of solvent extraction and column chromatography separatio...The distillation residues of middle-temperature coal tar(DRMCT) were separated into saturate, aromatic, resin and asphaltene fractions by using the combination of solvent extraction and column chromatography separation.The isolated four fractions have been further characterized through the combination of elemental analysis,Fourier transform infrared(FTIR) spectra, proton nuclear magnetic resonance spectrum(~1H NMR) and molecular weight analysis. The analysis results confirm the view that the saturate fraction from DRMCT was mainly composed of long-chain alkanes and almost all of the heteroatoms(S, N and O) were existed in aromatic structures.The asphaltene fraction had the highest molecular weight, the most amount of heteroatom(especially oxygen)and was the most condensed with shortest alkyl side chains among all the fractions. In addition, for the heavier components, the resin and asphaltene fractions from DRMCT contained lower ratio of H/C, lower molecular weight and higher aromaticity degree when compared with crude oils.展开更多
Manganese(Mn)is an essential micronutrient in plants.However,excessive Mn absorption in acidic and waterlogged soils can lead to Mn toxicity.Despite their essential roles in Mn homeostasis,transcriptional and post-tra...Manganese(Mn)is an essential micronutrient in plants.However,excessive Mn absorption in acidic and waterlogged soils can lead to Mn toxicity.Despite their essential roles in Mn homeostasis,transcriptional and post-transcriptional modifications of Mn transporters remain poorly understood.Here,we demonstrated that high-Mn stress induces an obvious Ca^(2+) signature in Arabidopsis.We identified four calcium-dependent protein kinases,CPK4/5/6/11,that interact with the tonoplast-localized Mn and iron(Fe)transporter MTP8 in vitro and in vivo.The cpk4/5/6/11 quadruple mutant displayed a dramatic high-Mn-sensitive phenotype similar to that of the mtp8 mutant.CPKs phosphorylated the N-terminal domain of MTP8 primarily at the Ser31 and Ser32 residues.Transport assays combined with multiple physiological experiments on phospho-dead variant MTP8^(S31/32A)and phospho-mimetic variant MTP8^(S31/32D)plants under different Mn and Fe conditions suggested that Ser31 and Ser32 are crucial for MTP8 function.In addition,genetic analysis showed that CPKs functioned upstream of MTP8.In summary,we identified a tonoplast-associated calcium signaling cascade that orchestrates Mn homeostasis and links Mn toxicity,Ca^(2+) signaling,and Mn transporters.These findings provide new insight into Mn homeostasis mechanisms and Ca^(2+) signaling pathways in plants,providing potential targets for engineering heavy metal toxicity-tolerant plants.展开更多
Plants adapt to their ever-changing environment via positive and negative signals induced by environmental stimuli.Drought stress,for instance,induces accumulation of the plant hormone abscisic acid(ABA),triggering AB...Plants adapt to their ever-changing environment via positive and negative signals induced by environmental stimuli.Drought stress,for instance,induces accumulation of the plant hormone abscisic acid(ABA),triggering ABA signal transduction.However,the molecular mechanisms for switching between plant growth promotion and stress response remain poorly understood.Here we report that RAF(rapidly accelerated fibrosarcoma)-LIKE MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 22(RAF22)in Arabidopsis tha/iana physically interacts with ABA INSENSITIVE 1(ABl1)and phosphorylates ABl1 at Ser416 residue to enhance its phosphatase activity.Interestingly,ABl1 can also enhance the activity of RAF22 through dephosphorylation,reciprocally inhibiting ABA signaling and promoting the maintenance of plant growth under normal conditions.Under drought stress,however,the ASA-activated OPEN STOMATA1(OST1)phosphorylates the Ser81 residue of RAF22 and inhibits its kinase activity,restraining its enhancement of ABl1 activity.Taken together,our study reveals that RAF22,ABl1,and OST1 form a dynamic regulatory network that plays crucial roles in optimizing plant growth and environmental adaptation under drought stress.展开更多
MnO_x-CeO_2 catalysts were synthesized to investigate the active sites for NO oxidation by varying the calcination temperature. XRD and TEM results showed that cubic CeO_2 and amorphous MnO_x existed in MnO_x-CeO_2 ca...MnO_x-CeO_2 catalysts were synthesized to investigate the active sites for NO oxidation by varying the calcination temperature. XRD and TEM results showed that cubic CeO_2 and amorphous MnO_x existed in MnO_x-CeO_2 catalysts. High temperature calcination caused the sintering of amorphous MnO_x and transforming to bulk crystalline Mn_2O_3, H_2-TPR and XPS results suggested the valence of Mn in MnO_x-CeO_2 was higher than pure MnO_x, and decreased with the increasing calcination temperature, The turnover frequency(TOF) was calculated based on the initial reducibility according to H_2-TPR quantitation and kinetic study. The TOF results indicated that the initial reducibility of amorphous MnO_x with high valence manganese ions was equivalent to the active sites for NO oxidation. It can be inferred that the amorphous MnO_x plays a key role in low-temperature NO oxidation.展开更多
In the present study, chemical mapping on the hydration process of cement paste with water-to-cement (w/c) ratio of 0.60 was implemented by Raman spectroscopy (RS). The RS was applied to study the paste from 12 ho...In the present study, chemical mapping on the hydration process of cement paste with water-to-cement (w/c) ratio of 0.60 was implemented by Raman spectroscopy (RS). The RS was applied to study the paste from 12 hours after mixing to 28 days. Cement ingredients and hydration products, including calcium silicates (C3S and C2S), calcium hydroxide (CH), and ettringite, were quantitatively studied. From the research, it is observed that calcium silicates were consumed gradually with the increased hydration age. Calcium hydroxide increased and tended to cluster in the pore vicinity during hydration. Ettringite was found to form on the surface of the unreacted particles, which was shown as a mixed zone of ettringite and calcium silicates in the maps. It is concluded from the study that chemical mapping was an effective method to assist in visualizing particle dispersion and connection on top of the quantitative analysis.展开更多
Color-changeable fbers can provide diverse functions for intelligent wearable devices such as novel information displays and human-machine interfaces when woven into fabric.This work develops a low-cost,efective,and s...Color-changeable fbers can provide diverse functions for intelligent wearable devices such as novel information displays and human-machine interfaces when woven into fabric.This work develops a low-cost,efective,and scalable strategy to produce thermochromic fbers by wet spinning.Through a combination of diferent thermochromic microcapsules,fexible fbers with abundant and reversible color changes are obtained.These color changes can be clearly observed by the naked eye.It is also found that the fbers exhibit excellent color-changing stability even after 8000 thermal cycles.Moreover,the thermochromic fbers can be fabricated on a large scale and easily woven or implanted into various fabrics with good mechanical performance.Driven by their good mechanical and physical characteristics,applications of thermochromic fbers in dynamic colored display are demonstrated.Dynamic quick response(QR)code display and recognition are successfully realized with thermochromic fabrics.This work well confrms the potential applications of thermochromic fbers in smart textiles,wearable devices,fexible displays,and human-machine interfaces.展开更多
基金supported by the National Natural Science Foundation of China (The key trusted running technologies for the sensing nodes in Internet of things: 61501007, The research of the trusted and security environment for high energy physics scientific computing system: 11675199)General Project of science and technology project of Beijing Municipal Education Commission: KM201610005023+2 种基金the outstanding personnel training program of Beijing municipal Party Committee Organization Department (The Research of Trusted Computing environment for Internet of things in Smart City: 2014000020124G041)The key technology research and validation issue for the emergency treatment telemedicine public service platform which integrates the military and civilian and bases on the broadband wireless networks (No.2013ZX03006001-005)the issue belongs to Major national science and technology projects
文摘Internet of things has been widely applied to industrial control, smart city and environmental protection, in these application scenarios, sensing node needs to make real-time response to the feedback control of the application layer. Therefore, it is necessary to monitor whether or not awareness nodes are trusted in real time, but the existing mechanisms for trusted certification lack the real-time measurement and tracking of the sensing node. To solve the above problems,this paper proposes a dynamic metric based authentication mechanism for sensing nodes of Internet of things. Firstly, the dynamic trustworthiness measure of the sensing nodes is carried out by introducing the computational function such as the trust function, the trustworthiness risk assessment function, the feedback control function and the active function of the sensing node. The dynamic trustworthiness measure of sensing nodes from multiple dimensions can effectively describe the change of trusted value of sensing nodes. Then, on the basis of this, a trusted attestation based on node trusted measure is realized by using the revocable group signature mechanism of local verifier. The mechanism has anonymity, unforgeability and traceability, which is proved the security in the standard model. Simulationexperiments show that the proposed trusted attestation mechanism is flexible, practical and efficient and has better attack resistance. It can effectively guarantee the reliable data transmission of nodes and realize the dynamic tracking of node reliability, which has a lower impact on system performance.
文摘Photobiomodulation using light in the red or near-infrared region is an innovative treatment strategy for a wide range of neurological and psychological conditions.Photobiomodulation can promote neurogenesis and elicit anti-apoptotic,antiinflammatory and antioxidative responses.Its therapeutic effects have been demonstrated in studies on neurological diseases,peripheral nerve injuries,pain relief and wound healing.We conducted a comprehensive literature review of the application of photobiomodulation in patients with central nervous system diseases in February 2019.The NCBI PubMed database,EMBASE database,Cochrane Library and ScienceDirect database were searched.We reviewed 95 papers and analyzed.Photobiomodulation has wide applicability in the treatment of stroke,traumatic brain injury,Parkinson’s disease,Alzheimer’s disease,major depressive disorder,and other diseases.Our analysis provides preliminary evidence that PBM is an effective therapeutic tool for the treatment of central nervous system diseases.However,additional studies with adequate sample size are needed to optimize treatment parameters.
基金Supported by the Natural Science Basic Research Plan in Shaanxi Province of China(2016JM5024)Scientific Research Program of Shaanxi Provincial Education Department(14JK1801)Xianyang Normal University Special Research Fund(15XSYK040)
文摘The distillation residues of middle-temperature coal tar(DRMCT) were separated into saturate, aromatic, resin and asphaltene fractions by using the combination of solvent extraction and column chromatography separation.The isolated four fractions have been further characterized through the combination of elemental analysis,Fourier transform infrared(FTIR) spectra, proton nuclear magnetic resonance spectrum(~1H NMR) and molecular weight analysis. The analysis results confirm the view that the saturate fraction from DRMCT was mainly composed of long-chain alkanes and almost all of the heteroatoms(S, N and O) were existed in aromatic structures.The asphaltene fraction had the highest molecular weight, the most amount of heteroatom(especially oxygen)and was the most condensed with shortest alkyl side chains among all the fractions. In addition, for the heavier components, the resin and asphaltene fractions from DRMCT contained lower ratio of H/C, lower molecular weight and higher aromaticity degree when compared with crude oils.
基金Acknowledgment This work was financially supported by the National Natural Science Foundation of China (No. 60317101), Key Research and Development Plan of Shandong Province (No. 2015GSF11500), and Natural Science Foundation of Shandong Province (No. ZR2013FL029).
文摘纤维激光水中听音器由于唯一的优点和宽广申请前景得到了普遍担心。在这篇论文,研究八元素的多路的纤维激光结果声学的压力数组和讯问系统被介绍,包含的低噪音的分布式的反馈纤维激光(DFB-FL ) 制造,包装的敏感改进,和 interferometric 表明解调。系统的频率反应范围是 10Hz-10kHz,声学的压力敏感到达的激光频率 115 dB re Hz/Pa,和声学的压力是的相等的噪音不到 60Pa/Hz <sup>1/2</sup> 。系统的动态范围比 120 dB 大。
基金funded by grants from the National Natural Science Foundation of China(31770289 to C.W.)Northwest A&F University(Z111021604 to C.W.)+1 种基金the China Postdoctoral Science Foundation(Z109021802 to Z.Z.)partially supported by the open funds of the State Key Laboratory of Plant Physiology and Biochemistry'(SKLPPBKF1901 to Z.Z.).
文摘Manganese(Mn)is an essential micronutrient in plants.However,excessive Mn absorption in acidic and waterlogged soils can lead to Mn toxicity.Despite their essential roles in Mn homeostasis,transcriptional and post-transcriptional modifications of Mn transporters remain poorly understood.Here,we demonstrated that high-Mn stress induces an obvious Ca^(2+) signature in Arabidopsis.We identified four calcium-dependent protein kinases,CPK4/5/6/11,that interact with the tonoplast-localized Mn and iron(Fe)transporter MTP8 in vitro and in vivo.The cpk4/5/6/11 quadruple mutant displayed a dramatic high-Mn-sensitive phenotype similar to that of the mtp8 mutant.CPKs phosphorylated the N-terminal domain of MTP8 primarily at the Ser31 and Ser32 residues.Transport assays combined with multiple physiological experiments on phospho-dead variant MTP8^(S31/32A)and phospho-mimetic variant MTP8^(S31/32D)plants under different Mn and Fe conditions suggested that Ser31 and Ser32 are crucial for MTP8 function.In addition,genetic analysis showed that CPKs functioned upstream of MTP8.In summary,we identified a tonoplast-associated calcium signaling cascade that orchestrates Mn homeostasis and links Mn toxicity,Ca^(2+) signaling,and Mn transporters.These findings provide new insight into Mn homeostasis mechanisms and Ca^(2+) signaling pathways in plants,providing potential targets for engineering heavy metal toxicity-tolerant plants.
基金supported by grants from the National Science Foundation of China(31730007 and 31921001)。
文摘Plants adapt to their ever-changing environment via positive and negative signals induced by environmental stimuli.Drought stress,for instance,induces accumulation of the plant hormone abscisic acid(ABA),triggering ABA signal transduction.However,the molecular mechanisms for switching between plant growth promotion and stress response remain poorly understood.Here we report that RAF(rapidly accelerated fibrosarcoma)-LIKE MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 22(RAF22)in Arabidopsis tha/iana physically interacts with ABA INSENSITIVE 1(ABl1)and phosphorylates ABl1 at Ser416 residue to enhance its phosphatase activity.Interestingly,ABl1 can also enhance the activity of RAF22 through dephosphorylation,reciprocally inhibiting ABA signaling and promoting the maintenance of plant growth under normal conditions.Under drought stress,however,the ASA-activated OPEN STOMATA1(OST1)phosphorylates the Ser81 residue of RAF22 and inhibits its kinase activity,restraining its enhancement of ABl1 activity.Taken together,our study reveals that RAF22,ABl1,and OST1 form a dynamic regulatory network that plays crucial roles in optimizing plant growth and environmental adaptation under drought stress.
基金Project supported by the National key research and development program(2016YFC0204901)the National Natural Science Foundation of China(21576207)the introduction of talent and technology cooperation plan of Tianjin(14RCGFGX00849)
文摘MnO_x-CeO_2 catalysts were synthesized to investigate the active sites for NO oxidation by varying the calcination temperature. XRD and TEM results showed that cubic CeO_2 and amorphous MnO_x existed in MnO_x-CeO_2 catalysts. High temperature calcination caused the sintering of amorphous MnO_x and transforming to bulk crystalline Mn_2O_3, H_2-TPR and XPS results suggested the valence of Mn in MnO_x-CeO_2 was higher than pure MnO_x, and decreased with the increasing calcination temperature, The turnover frequency(TOF) was calculated based on the initial reducibility according to H_2-TPR quantitation and kinetic study. The TOF results indicated that the initial reducibility of amorphous MnO_x with high valence manganese ions was equivalent to the active sites for NO oxidation. It can be inferred that the amorphous MnO_x plays a key role in low-temperature NO oxidation.
基金Acknowledgements The financial supports from the National Science Foundation (CMMI-1265983), the Department of Civil and Environmental Engineering, and the Graduate School Diversity Research Grant for Graduate Students (CODRE) at the University of Louisville, are highly appreciated. We also thank the Conn's Center for providing Raman spectroscopy. The authors also appreciate Dr. Chengqing Qi from CEMEX Technical Center for cement chemical composition analysis.
文摘In the present study, chemical mapping on the hydration process of cement paste with water-to-cement (w/c) ratio of 0.60 was implemented by Raman spectroscopy (RS). The RS was applied to study the paste from 12 hours after mixing to 28 days. Cement ingredients and hydration products, including calcium silicates (C3S and C2S), calcium hydroxide (CH), and ettringite, were quantitatively studied. From the research, it is observed that calcium silicates were consumed gradually with the increased hydration age. Calcium hydroxide increased and tended to cluster in the pore vicinity during hydration. Ettringite was found to form on the surface of the unreacted particles, which was shown as a mixed zone of ettringite and calcium silicates in the maps. It is concluded from the study that chemical mapping was an effective method to assist in visualizing particle dispersion and connection on top of the quantitative analysis.
基金supported by the National Natural Science Foundation of China(Grant Nos.62175082 and 61875064).
文摘Color-changeable fbers can provide diverse functions for intelligent wearable devices such as novel information displays and human-machine interfaces when woven into fabric.This work develops a low-cost,efective,and scalable strategy to produce thermochromic fbers by wet spinning.Through a combination of diferent thermochromic microcapsules,fexible fbers with abundant and reversible color changes are obtained.These color changes can be clearly observed by the naked eye.It is also found that the fbers exhibit excellent color-changing stability even after 8000 thermal cycles.Moreover,the thermochromic fbers can be fabricated on a large scale and easily woven or implanted into various fabrics with good mechanical performance.Driven by their good mechanical and physical characteristics,applications of thermochromic fbers in dynamic colored display are demonstrated.Dynamic quick response(QR)code display and recognition are successfully realized with thermochromic fabrics.This work well confrms the potential applications of thermochromic fbers in smart textiles,wearable devices,fexible displays,and human-machine interfaces.