Coaxial fiber-shaped supercapacitors are a promising class of energy storage devices requiring high performance for flexible and miniature electronic devices.Yet,they are still struggling from inferior energy density,...Coaxial fiber-shaped supercapacitors are a promising class of energy storage devices requiring high performance for flexible and miniature electronic devices.Yet,they are still struggling from inferior energy density,which comes from the limited choices in materials and structure used.Here,Zn-doped CuO nanowires were designed as 3D framework for aligned distributing high mass loading of MnO2 nanosheets.Zn could be introduced into the CuO crystal lattice to tune the covalency character and thus improve charge transport.The Zn–CuO@MnO2 as positive electrode obtained superior performance without sacrificing its areal and gravimetric capacitances with the increasing of mass loading of MnO2 due to 3D Zn–CuO framework enabling efficient electron transport.A novel category of free-standing asymmetric coaxial fiber-shaped supercapacitor based on Zn0.11CuO@MnO2 core electrode possesses superior specific capacitance and enhanced cell potential window.This asymmetric coaxial structure provides superior performance including higher capacity and better stability under deformation because of sufficient contact between the electrodes and electrolyte.Based on these advantages,the as-prepared asymmetric coaxial fiber-shaped supercapacitor exhibits a high specific capacitance of 296.6 mF cm^−2 and energy density of 133.47μWh cm^−2.In addition,its capacitance retention reaches 76.57%after bending 10,000 times,which demonstrates as-prepared device’s excellent flexibility and long-term cycling stability.展开更多
Poor heat/flame-resistance of polyolefin(e.g.,polyethylene and polypropylene)separators and high flammability of organic electrolytes used in today’s lithium-ion batteries(LIBs)may trigger rare yet potentially catast...Poor heat/flame-resistance of polyolefin(e.g.,polyethylene and polypropylene)separators and high flammability of organic electrolytes used in today’s lithium-ion batteries(LIBs)may trigger rare yet potentially catastrophic safety issues.Here,we mitigate this challenge by developing a heat-resistant and flame-retardant porous composite membrane composed of polyetherimide(PEI)and Al_(2)O_(3) nanowires(NWs).The membranes are fabricated based on an industrially scalable non-solvent-induced phase separation process,which results in an intimately interconnected porous network of Al_(2)O_(3) NWs and PEI.The produced composite membranes exhibit excellent flexibility,thermal stability,and flame-retardancy.Importantly,the composite membranes exhibit minimal thermal shrinkage and superior tensile strength(16 MPa)at temperatures as high as 200℃,significantly exceeding the performance of conventional polyolefin separators.Compared with commercial separators,their superior wettability and higher ionic conductivity(by up to 2.4 times)when filled with the same electrolyte,larger electrolyte uptake(-190 wt.%),as well as improved cycle and rate performance demonstrated in LiNiMnCoO_(2)(NCM)-based LIBs make them attractive choices for a variety of electrochemical energy storage devices.展开更多
Organoids have attracted great interest for disease modelling,drug discovery and development,and tissue growth and homeostasis investigations.However,lack of standards for quality control has become a prominent obstac...Organoids have attracted great interest for disease modelling,drug discovery and development,and tissue growth and homeostasis investigations.However,lack of standards for quality control has become a prominent obstacle to limit their translation into clinic and other applications.“Human intestinal organoids”is the first guideline on human intestinal organoids in China,jointly drafted and agreed by the experts from the Chinese Society for Cell Biology and its branch society:the Chinese Society for Stem Cell Research.This standard specifies terms and definitions,technical requirements,test methods,inspection rules for human intestinal organoids,which is applicable to quality control during the process of manufacturing and testing of human intestinal organoids.It was originally released by the Chinese Society for Cell Biology on 24 September 2022.We hope that the publication of this standard will guide institutional establishment,acceptance and execution of proper practical protocols and accelerate the international standardization of human intestinal organoids for applications.展开更多
Intestinal cancer is one of the most frequent and lethal types of cancer.Modeling intestinal cancer using organoids has emerged in the last decade.Human intestinal cancer organoids are physiologically relevant in vitr...Intestinal cancer is one of the most frequent and lethal types of cancer.Modeling intestinal cancer using organoids has emerged in the last decade.Human intestinal cancer organoids are physiologically relevant in vitro models,which provides an unprecedented opportunity for fundamental and applied research in colorectal cancer.“Human intestinal cancer organoids”is the first set of guidelines on human intestinal organoids in China,jointly drafted and agreed by the experts from the Chinese Society for Cell Biology and its branch society:the Chinese Society for Stem Cell Research.This standard specifies terms and definitions,technical requirements,test methods for human intestinal cancer organoids,which apply to the production and quality control during the process of manufacturing and testing of human intestinal cancer organoids.It was released by the Chinese Society for Cell Biology on 24 September 2022.We hope that the publication of this standard will guide institutional establishment,acceptance and execution of proper practocal protocols,and accelerate the international standardization of human intestinal cancer organoids for clinical development and therapeutic applications.展开更多
基金the National Natural Science Foundation of China(Nos.21975281,21773293,21603264)CAS Pioneer Hundred Talents Program,the National Key Research and Development Program of China(2016YFA0203301)+1 种基金Jiangsu Planned Projects for Postdoctoral Research Funds(2019K048)Suzhou Science and Technology Plan Project(SYG201926).
文摘Coaxial fiber-shaped supercapacitors are a promising class of energy storage devices requiring high performance for flexible and miniature electronic devices.Yet,they are still struggling from inferior energy density,which comes from the limited choices in materials and structure used.Here,Zn-doped CuO nanowires were designed as 3D framework for aligned distributing high mass loading of MnO2 nanosheets.Zn could be introduced into the CuO crystal lattice to tune the covalency character and thus improve charge transport.The Zn–CuO@MnO2 as positive electrode obtained superior performance without sacrificing its areal and gravimetric capacitances with the increasing of mass loading of MnO2 due to 3D Zn–CuO framework enabling efficient electron transport.A novel category of free-standing asymmetric coaxial fiber-shaped supercapacitor based on Zn0.11CuO@MnO2 core electrode possesses superior specific capacitance and enhanced cell potential window.This asymmetric coaxial structure provides superior performance including higher capacity and better stability under deformation because of sufficient contact between the electrodes and electrolyte.Based on these advantages,the as-prepared asymmetric coaxial fiber-shaped supercapacitor exhibits a high specific capacitance of 296.6 mF cm^−2 and energy density of 133.47μWh cm^−2.In addition,its capacitance retention reaches 76.57%after bending 10,000 times,which demonstrates as-prepared device’s excellent flexibility and long-term cycling stability.
基金financially supported by Sila Nanotechnologies,Inc.(Sila)additional fellowship support of China Scholarship Councilsupported by the National Science Foundation(No.ECCS-2025462).
文摘Poor heat/flame-resistance of polyolefin(e.g.,polyethylene and polypropylene)separators and high flammability of organic electrolytes used in today’s lithium-ion batteries(LIBs)may trigger rare yet potentially catastrophic safety issues.Here,we mitigate this challenge by developing a heat-resistant and flame-retardant porous composite membrane composed of polyetherimide(PEI)and Al_(2)O_(3) nanowires(NWs).The membranes are fabricated based on an industrially scalable non-solvent-induced phase separation process,which results in an intimately interconnected porous network of Al_(2)O_(3) NWs and PEI.The produced composite membranes exhibit excellent flexibility,thermal stability,and flame-retardancy.Importantly,the composite membranes exhibit minimal thermal shrinkage and superior tensile strength(16 MPa)at temperatures as high as 200℃,significantly exceeding the performance of conventional polyolefin separators.Compared with commercial separators,their superior wettability and higher ionic conductivity(by up to 2.4 times)when filled with the same electrolyte,larger electrolyte uptake(-190 wt.%),as well as improved cycle and rate performance demonstrated in LiNiMnCoO_(2)(NCM)-based LIBs make them attractive choices for a variety of electrochemical energy storage devices.
基金supported by grants from the National Natural Science Foundation of China(31988101 to Y.-G.C.82173461 To G.Q.H.)+3 种基金Guangdong Basic and Applied Basic Research Foundation(2021A1515111215)to Y.L.W.China Postdoctoral Science Foundation(2021M703230 and 2022T150653)to Y.L.W.National Key R&D Program of China(2018YFA0108400)to T.B.Z.the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16040501)to A.J.M..
文摘Organoids have attracted great interest for disease modelling,drug discovery and development,and tissue growth and homeostasis investigations.However,lack of standards for quality control has become a prominent obstacle to limit their translation into clinic and other applications.“Human intestinal organoids”is the first guideline on human intestinal organoids in China,jointly drafted and agreed by the experts from the Chinese Society for Cell Biology and its branch society:the Chinese Society for Stem Cell Research.This standard specifies terms and definitions,technical requirements,test methods,inspection rules for human intestinal organoids,which is applicable to quality control during the process of manufacturing and testing of human intestinal organoids.It was originally released by the Chinese Society for Cell Biology on 24 September 2022.We hope that the publication of this standard will guide institutional establishment,acceptance and execution of proper practical protocols and accelerate the international standardization of human intestinal organoids for applications.
基金supported by grants from the National Natural Science Foundation of China(31988101 to Y.-G.C.82173461 To G.Q.H.)+3 种基金Guangdong Basic and Applied Basic Research Foundation(2021A1515111215)to Y.L.W.China Postdoctoral Science Foundation(2021M703230 and 2022T150653)to Y.L.W.National Key R&D Program of China(2018YFA0108400)to T.B.Z.the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16040501)to A.J.M..
文摘Intestinal cancer is one of the most frequent and lethal types of cancer.Modeling intestinal cancer using organoids has emerged in the last decade.Human intestinal cancer organoids are physiologically relevant in vitro models,which provides an unprecedented opportunity for fundamental and applied research in colorectal cancer.“Human intestinal cancer organoids”is the first set of guidelines on human intestinal organoids in China,jointly drafted and agreed by the experts from the Chinese Society for Cell Biology and its branch society:the Chinese Society for Stem Cell Research.This standard specifies terms and definitions,technical requirements,test methods for human intestinal cancer organoids,which apply to the production and quality control during the process of manufacturing and testing of human intestinal cancer organoids.It was released by the Chinese Society for Cell Biology on 24 September 2022.We hope that the publication of this standard will guide institutional establishment,acceptance and execution of proper practocal protocols,and accelerate the international standardization of human intestinal cancer organoids for clinical development and therapeutic applications.