Objective:The aim of the study was to investigate the influence of gastric cancer family history in the gastric cancer (GC) patients. Methods: Gastric cancer family histories within second degree relatives and clinico...Objective:The aim of the study was to investigate the influence of gastric cancer family history in the gastric cancer (GC) patients. Methods: Gastric cancer family histories within second degree relatives and clinicopathological features were obtained for 497 patients. Results:Of the 497 probands,235 probands were incorporated into familial gastric cancer (FGC) group (there were at least two GC members in the family); 262 probands were included in the non-FGC group (relatives only affected with non-GCs). Of 614 tumors in relatives,GC was the most frequent,followed by lung cancer,esophageal cancer,hepatocellular cancer,colorectal cancer,urogenital cancer,breast cancer,and pancreatic cancer. Most affected members aggregated within first-degree relatives. The ratio of males to females in affected first-degree relatives was usually higher in male probands. Paternal history of GC was a strong risk for GC in males,while risk of GC by maternal history of GCs was increased in females. Difference in tumor histological types between the two groups was derived from an excess of diffuse GC in non-FGC male probands. The lower site was the most frequent tumor location in all subgroups. Conclusion:Distribution of associated non-GCs in a family history of GC may vary with geographic areas. GC may have different genetic and/or environmental etiology in different families,and a certain subtype may be inherited in a male-influenced fashion.展开更多
Vehicle ad hoc network (VANET) is a research hotspot in industrial and academic fields now and after. Dedicated short-range communication (DSRC) is a key technology of vehicular safety services and most research adher...Vehicle ad hoc network (VANET) is a research hotspot in industrial and academic fields now and after. Dedicated short-range communication (DSRC) is a key technology of vehicular safety services and most research adhere to IEEE 802.11p standard. The safety-related services face channel congestion, message collision, and hidden tinal problem in different traffic conditions. This paper focuses on the broadcast of safety-related message under different vehicle densities. In this paper, we firstly divide the safety-related messages into three categories and assign them different broadcast priorities. Secondly, we design different distributed broadcast algorithms for the three type messages. Then,we propose a method used to evaluate the vehicle density and present the relationship between the vehicle density and the transmit power. Then the safety module selects proper transmit power according to the relationship before the message is sent. Finally, we conduct the simulation experiment using NS3 software in the Linux environment. Simulation results show that the broadcast scheme can effectively ensure that the emergency message is correctly received in the 200m range for high vehicle density. Compared with the algorithm without considering the vehicle density, the performance has been greatly improved.展开更多
Dear Editor,Dent disease is a rare X-linked recessive disease that was first reported by Charles Enrique Dent and M.Friedman in 1964(Dent and Friedman,1964).Dent disease is caused by mutations in the CLCN5(Dent diseas...Dear Editor,Dent disease is a rare X-linked recessive disease that was first reported by Charles Enrique Dent and M.Friedman in 1964(Dent and Friedman,1964).Dent disease is caused by mutations in the CLCN5(Dent disease 1)or OCRL1(Dent disease 2).The condition is characterized by proximal renal tubular dysfunction that manifests as low molecular weight proteinuria(LMWP),hypercalciuria,nephrocalcinosis or nephrolithiasis,and progressive renal failure.Typically,the total protein excretion in tubular proteinuria is lower than that in glomerular diseases;therefore,nephrotic range proteinuria(NP)is not prevalent in patients with documented CLCN5 or OCRL1 mutations.Here,we report the cases of six Chinese children with Dent disease who manifested NP and were finally diagnosed using genetic analysis.Our aim was to elucidate the characteristics of Dent disease in Shaanxi area to facilitate possible improvements in its detection and treatment.展开更多
The cascade O-insertion/1,6 conjugate addition between benzynes and ortho-hydroxyphenyl substituted para-quinone methides has been reported, affording 9-phenol substituted xanthenes in 49%-84% yields.
基金Supported by two grants from the Science and Technology Program of Shenyang (No.1071166-9-00 and No.1081232-1-00)
文摘Objective:The aim of the study was to investigate the influence of gastric cancer family history in the gastric cancer (GC) patients. Methods: Gastric cancer family histories within second degree relatives and clinicopathological features were obtained for 497 patients. Results:Of the 497 probands,235 probands were incorporated into familial gastric cancer (FGC) group (there were at least two GC members in the family); 262 probands were included in the non-FGC group (relatives only affected with non-GCs). Of 614 tumors in relatives,GC was the most frequent,followed by lung cancer,esophageal cancer,hepatocellular cancer,colorectal cancer,urogenital cancer,breast cancer,and pancreatic cancer. Most affected members aggregated within first-degree relatives. The ratio of males to females in affected first-degree relatives was usually higher in male probands. Paternal history of GC was a strong risk for GC in males,while risk of GC by maternal history of GCs was increased in females. Difference in tumor histological types between the two groups was derived from an excess of diffuse GC in non-FGC male probands. The lower site was the most frequent tumor location in all subgroups. Conclusion:Distribution of associated non-GCs in a family history of GC may vary with geographic areas. GC may have different genetic and/or environmental etiology in different families,and a certain subtype may be inherited in a male-influenced fashion.
文摘Vehicle ad hoc network (VANET) is a research hotspot in industrial and academic fields now and after. Dedicated short-range communication (DSRC) is a key technology of vehicular safety services and most research adhere to IEEE 802.11p standard. The safety-related services face channel congestion, message collision, and hidden tinal problem in different traffic conditions. This paper focuses on the broadcast of safety-related message under different vehicle densities. In this paper, we firstly divide the safety-related messages into three categories and assign them different broadcast priorities. Secondly, we design different distributed broadcast algorithms for the three type messages. Then,we propose a method used to evaluate the vehicle density and present the relationship between the vehicle density and the transmit power. Then the safety module selects proper transmit power according to the relationship before the message is sent. Finally, we conduct the simulation experiment using NS3 software in the Linux environment. Simulation results show that the broadcast scheme can effectively ensure that the emergency message is correctly received in the 200m range for high vehicle density. Compared with the algorithm without considering the vehicle density, the performance has been greatly improved.
基金funded by the Natural Science Foundation of Shaanxi Province (S2018-JC-YB-2307)
文摘Dear Editor,Dent disease is a rare X-linked recessive disease that was first reported by Charles Enrique Dent and M.Friedman in 1964(Dent and Friedman,1964).Dent disease is caused by mutations in the CLCN5(Dent disease 1)or OCRL1(Dent disease 2).The condition is characterized by proximal renal tubular dysfunction that manifests as low molecular weight proteinuria(LMWP),hypercalciuria,nephrocalcinosis or nephrolithiasis,and progressive renal failure.Typically,the total protein excretion in tubular proteinuria is lower than that in glomerular diseases;therefore,nephrotic range proteinuria(NP)is not prevalent in patients with documented CLCN5 or OCRL1 mutations.Here,we report the cases of six Chinese children with Dent disease who manifested NP and were finally diagnosed using genetic analysis.Our aim was to elucidate the characteristics of Dent disease in Shaanxi area to facilitate possible improvements in its detection and treatment.
基金supported by the National Natural Science Foundation of China(No. 21462034)the Young Scientists Foundation of Shihezi University(Nos. RCZX201546, 2015ZRKXJQ05)the Excellent Young Teachers Plan of Bingtuan(No. CZ027203)
文摘The cascade O-insertion/1,6 conjugate addition between benzynes and ortho-hydroxyphenyl substituted para-quinone methides has been reported, affording 9-phenol substituted xanthenes in 49%-84% yields.
