Semi-analytic solution of Eringen's two-phase local/nonlocal model for Euler-Bernoulli beam with axial force

Eringen’s two-phase local/nonlocal model is applied to an Euler-Bernoulli nanobeam considering the bending-induced axial force, where the contribution of the axial force to bending moment is calculated on the deformed state. Basic equations for the corresponding one-dimensional beam problem are obtained by degenerating from the three-dimensional nonlocal elastic equations. Semi-analytic solutions are then presented for a clamped-clamped beam subject to a concentrated force and a uniformly distributed load, respectively. Except for the traditional essential boundary conditions and those required to be satisfied by transferring an integral equation to its equivalent differential form, additional boundary conditions are needed and should be chosen with great caution, since numerical results reveal that non-unique solutions might exist for a nonlinear problem if inappropriate boundary conditions are used. The validity of the solutions is examined by plotting both sides of the original integro-differential governing equation of deflection and studying the error between both sides. Besides, an increase in the internal characteristic length would cause an increase in the deflection and axial force of the beam.

A novel nest-based scheduling method for mobile wireless body area networks

Wireless Body Area Networks(WBANs)comprise various sensors to monitor and collect various vital signals,such as blood pressure,pulse,heartbeat,body temperature,and blood sugar.A dense and mobile WBAN often suffers from interference,which causes serious problems,such as wasting energy and degrading throughput.In reality,not all of the sensors in WBAN need to be active at the same time.Therefore,they can be divided into different groups so that each group works in turn to avoid interference.In this paper,a Nest-Based WBAN Scheduling(NBWS)algorithm is proposed to cluster sensors of the same types in a single or multiple WBANs into different groups to avoid interference.Particularly,we borrow the graph coloring theory to schedule all groups to work using a Time Division for Multimodal Sensor(TDMS)group scheduling model.Both theoretical analysis and experimental results demonstrate that the proposed NBWS algorithm performs better in terms of frequency of collisions,transmission delay,system throughput,and energy consumption compared to the counterpart methods.

The Implementation of Electronic Intelligent Tag System Based on Wireless Sensor Network

Recently, Wireless Sensor Network (WSN) has been widely applied in many fields. In this paper, we design and implement a WSN-based Electronic Intelligent Tag System (EITS) to provide intelligent management of the modern supermarkets. As a main transceiver, nRF24L01+ wireless module is used in this system, which will make it possible to achieve low-power and low-cost for EITS. This system fully embodies the advantages and characteristics of WSN. This paper will introduce the system architecture, hardware structure and software design in details;and put forward a specific solution. Finally, we achieve the intelligent management of the mall based on wireless sensor network technology.

Neddylation is a novel therapeutic target for lupus by regulating double negative T cell homeostasis

Systemic lupus erythematosus(SLE),a severe autoimmune disorder,is characterized by systemic inflammatory response,autoantibody accumulation and damage to organs.The dysregulation of double-negative(DN)T cells is considered as a crucial commander during SLE.Neddylation,a significant type of protein post-translational modification(PTM),has been well-proved to regulate T cell-mediated immune response.However,the function of neddylation in SLE is still unknown.Here,we reported that neddylation inactivation with MLN4924,a specific inhibitor of NEDD8-activating enzyme E1(NAE1),or genetic abrogation of Ube2m in T cells decreased DN T cell accumulation and attenuated murine lupus development.Further investigations revealed that inactivation of neddylation blocked Bim ubiquitination degradation and maintained Bim level in DN T cells,contributing to the apoptosis of the accumulated DN T cells in lupus mice.Then double knockout(KO)lupus-prone mice(Ube2m-/-Bim-/-lpr)were generated and results showed that loss of Bim reduced Ube2m deficiency-induced apoptosis in DN T cells and reversed the alleviated lupus progression.Our findings identified that neddylation inactivation promoted Bim-mediated DN T cell apoptosis and attenuated lupus progression.Clinically,we also found that in SLE patients,the proportion of DN T cells was raised and their apoptosis was reduced.Moreover,compared to healthy groups,SLE patients exhibited decreased Bim levels and elevated Cullin1 neddylation levels.Meantime,the inhibition of neddylation induced Bim-dependent apoptosis of DN T cells isolated from SLE patients.Altogether,our findings provide the direct evidence about the function of neddylation during lupus,suggesting a promising therapeutic approach for this disease.

Treatment Effects of Integrated TCM and Western Medicine Treatment Scheme on COVID-19: A Single-armed Clinical Trial

Backgroud:The outbreak of COVID-19 has brought unprecedented perils to human health and raised public health concerns in more than two hundred countries.Safe and effective treatment scheme is needed urgently.Objective:To evaluate the effects of integratedTCM and western medicine treatment scheme on COVID-19.Methods:A single-armed clinical trial was carried out in Hangzhou Xixi Hospital,an affiliated hospital with Zhejiang Chinese Medical University.102 confirmed cases were screened out from 725 suspected cases and 93 of them were treated with integrated TCM and western medicine treatment scheme.Results:83 cases were cured,5 cases deteriorated,and 5 cases withdrew from the study.No deaths were reported.The mean relief time of fever,cough,diarrhea,and fatigue were(4.78±4.61)days,(7.22±4.99)days,(5.28±3.39)days,and(5.28±3.39)days,respectively.It took(14.84±5.50)days for SARS-CoV-2 by nucleic acid amplification-based testing to turn negative.Multivariable cox regression analysis revealed that age,BMI,PISCT,BPC,AST,CK,BS,and UPRO were independent risk factors for COVID-19 treatment.Conclusion:Our study suggested that integrated TCM and western medicine treatment scheme was effective for COVID-19.