Simultaneously forming a carbon-carbon and a carbon-heteroatom bond in a single step through transition metal-catalyzed alkene difunctionalization strategy has emerged as a powerful tool for synthetic organic chemistr...Simultaneously forming a carbon-carbon and a carbon-heteroatom bond in a single step through transition metal-catalyzed alkene difunctionalization strategy has emerged as a powerful tool for synthetic organic chemistry.Due to the uncontrollable reactivity,direct cross-coupling with bromoallenes as the building blocks for the selective allenation and borylation remains challenging.We herein report a new type of S-and P-stabilized bromoallenes for palladium-catalyzed modular allenation and borylation of alkenes to the divergent synthesis of multiply functionalized allenes in a highly regio-and diastereoselective manifold.The reaction features broad substrate scope and wide functional group compatibility,thus providing a straightforward method to install allenyl and boryl groups across alkenes.Control experiments highlight the crucial importance of S-,P-stabilization for the oxidative insertion of Pd-species into the allenyl-Br bond.The facile syntheses of bioactive allenic steroids and exocyclic allenes demonstrate the synthetic utility of this protocol.展开更多
Saliva is one of the important body fluids that reflects normal internal characteristics and disease state of an individual.As a multi-composition oral fluid,has high potential for the surveillance of general health a...Saliva is one of the important body fluids that reflects normal internal characteristics and disease state of an individual.As a multi-composition oral fluid,has high potential for the surveillance of general health and disease,which contains various disease signal biomarkers and is non-invasive,convenient,fast and easy to be accepted by patients.At present,saliva is increasingly used as a biological fluid for diagnosis,monitoring systemic disease states and predicting disease progression,which has been verified.In this review,the molecular compositions and effectiveness of saliva as reliable biological fluid were discussed.Besides the latest research progress in the diagnosis of saliva related to 14 organs were reviewed.The factors affecting saliva diagnosis were discussed.The method to improve the accuracy of prediction through artificial intelligence combined with microfluidic chip was proposed,which laid the foundation for dealing with the prevention,diagnosis,and treatment of related diseases through saliva with great and long-term significance.展开更多
基金supported by the National Natural Science Foundation of China(22322108)Jiangsu Specially Appointed Professors Plan(SR10900122)the Natural Science Foundation of Jiangsu Province(BK20221355)。
文摘Simultaneously forming a carbon-carbon and a carbon-heteroatom bond in a single step through transition metal-catalyzed alkene difunctionalization strategy has emerged as a powerful tool for synthetic organic chemistry.Due to the uncontrollable reactivity,direct cross-coupling with bromoallenes as the building blocks for the selective allenation and borylation remains challenging.We herein report a new type of S-and P-stabilized bromoallenes for palladium-catalyzed modular allenation and borylation of alkenes to the divergent synthesis of multiply functionalized allenes in a highly regio-and diastereoselective manifold.The reaction features broad substrate scope and wide functional group compatibility,thus providing a straightforward method to install allenyl and boryl groups across alkenes.Control experiments highlight the crucial importance of S-,P-stabilization for the oxidative insertion of Pd-species into the allenyl-Br bond.The facile syntheses of bioactive allenic steroids and exocyclic allenes demonstrate the synthetic utility of this protocol.
基金This project was supported by the Guangdong Basic and Applied Basic Research Foundation(Grant No.2020B1515120082)the Innovation Commission of Science and Technology of Shenzhen Municipality(Grant No.JCYJ20190807144001746,Grant No.JSGG20191129114422849)the Shenzhen Municipal Industrial and Information Technology Bureau(Grant No.20180309163834680).
文摘Saliva is one of the important body fluids that reflects normal internal characteristics and disease state of an individual.As a multi-composition oral fluid,has high potential for the surveillance of general health and disease,which contains various disease signal biomarkers and is non-invasive,convenient,fast and easy to be accepted by patients.At present,saliva is increasingly used as a biological fluid for diagnosis,monitoring systemic disease states and predicting disease progression,which has been verified.In this review,the molecular compositions and effectiveness of saliva as reliable biological fluid were discussed.Besides the latest research progress in the diagnosis of saliva related to 14 organs were reviewed.The factors affecting saliva diagnosis were discussed.The method to improve the accuracy of prediction through artificial intelligence combined with microfluidic chip was proposed,which laid the foundation for dealing with the prevention,diagnosis,and treatment of related diseases through saliva with great and long-term significance.
