Osteosarcoma (OS) is the most common histological form of primary bone cancer in childhood cancer and young adults. At present, OS is widely investigated because of the interaction between the tumor and bone microenvi...Osteosarcoma (OS) is the most common histological form of primary bone cancer in childhood cancer and young adults. At present, OS is widely investigated because of the interaction between the tumor and bone microenvironment and the effect of such interaction on OS progression and metastasis.1 The connective tissue growth factor (CTGF), also known as cellular communication network factor 2 (CCN2), is a secreted extracellular matrix-associated protein. CTGF is as active as the regulators of signaling activities of several different pathways and an orchestrator of their cross-talk.2 Therefore, we conducted experiments to investigate the effects of CTGF on OS tumor progress and the cross-talk with stromal cells in the tumor microenvironment.展开更多
The radical suppression of the photodarkening effect and laser performance deterioration via H2 loading were demonstrated in high-power Yb-doped fiber(YDF)amplifiers.The photodarkening loss at equilibrium was114.4 d B...The radical suppression of the photodarkening effect and laser performance deterioration via H2 loading were demonstrated in high-power Yb-doped fiber(YDF)amplifiers.The photodarkening loss at equilibrium was114.4 d B/m at 702 nm in the pristine fiber,while it vanished in the H2-loaded fiber.To obtain a deeper understanding of the impact of photodarkening on laser properties,the evolution of the mode instability threshold and output power in fiber amplifiers was investigated.After pumping for 300 min,the mode instability threshold of the pristine fiber dropped from 770 to 612 W,and the periodic fluctuation of the output power became intense,finally reaching 100 W.To address the detrimental effects originating from photodarkening,H2 loading was applied in contrast experiments.The output power remained stable,and no sign of mode instability was observed in the H2-loaded fiber.Moreover,the transmittance at 638 nm confirmed the absence of the photodarkening effect.The results pave the way for the further development of high-power fiber lasers.展开更多
基金supported by the National Natural Science Foundation of China(No.81102035,and 82060388)Doctor Foundation of Guizhou Provincial People's Hospital(No.GZSYBS[2019]08)+2 种基金Guizhou High-level Innovative Talents Project(No.QKPT[2017]5724-6)Guizhou Department and Platform Talents(No.[2017]5735-31)Science and Technology Department of Guizhou Province(No.QKHJC[2021-396]).
文摘Osteosarcoma (OS) is the most common histological form of primary bone cancer in childhood cancer and young adults. At present, OS is widely investigated because of the interaction between the tumor and bone microenvironment and the effect of such interaction on OS progression and metastasis.1 The connective tissue growth factor (CTGF), also known as cellular communication network factor 2 (CCN2), is a secreted extracellular matrix-associated protein. CTGF is as active as the regulators of signaling activities of several different pathways and an orchestrator of their cross-talk.2 Therefore, we conducted experiments to investigate the effects of CTGF on OS tumor progress and the cross-talk with stromal cells in the tumor microenvironment.
基金National Natural Science Foundation of China(61735007)National Key Research and Development Program of China(2017YFB1104400)。
文摘The radical suppression of the photodarkening effect and laser performance deterioration via H2 loading were demonstrated in high-power Yb-doped fiber(YDF)amplifiers.The photodarkening loss at equilibrium was114.4 d B/m at 702 nm in the pristine fiber,while it vanished in the H2-loaded fiber.To obtain a deeper understanding of the impact of photodarkening on laser properties,the evolution of the mode instability threshold and output power in fiber amplifiers was investigated.After pumping for 300 min,the mode instability threshold of the pristine fiber dropped from 770 to 612 W,and the periodic fluctuation of the output power became intense,finally reaching 100 W.To address the detrimental effects originating from photodarkening,H2 loading was applied in contrast experiments.The output power remained stable,and no sign of mode instability was observed in the H2-loaded fiber.Moreover,the transmittance at 638 nm confirmed the absence of the photodarkening effect.The results pave the way for the further development of high-power fiber lasers.
