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血浆miR-34b-3p和miR-302a-5p在非小细胞肺癌诊断中的临床应用 被引量:15
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作者 宋治鹏 张宗德 刘洋 《中国肺癌杂志》 CAS CSCD 北大核心 2019年第4期216-222,共7页
背景与目的微小核糖核酸(microRNA, miRNA)是一类长约22个核苷酸的单链非编码RNA,其表达异常与疾病密切相关。本研究旨在探讨miR-34b-3p和miR-302a-5p在非小细胞肺癌(non-small cell lung cancer, NSCLC)患者血浆中的表达水平及其在NSCL... 背景与目的微小核糖核酸(microRNA, miRNA)是一类长约22个核苷酸的单链非编码RNA,其表达异常与疾病密切相关。本研究旨在探讨miR-34b-3p和miR-302a-5p在非小细胞肺癌(non-small cell lung cancer, NSCLC)患者血浆中的表达水平及其在NSCLC诊断的临床应用价值研究。方法采用荧光定量PCR(real-time polymerase chain reaction, RT-PCR)对86例NSCLC患者、64例肺结核(pulmonary tuberculosis, PTB)患者、39例健康体检者血浆中的miR-34b-3p和miR-302a-5p含量进行测定,同时对比并结合癌胚抗原(carcino-embryonic antigen, CEA)、神经元烯醇化酶(neuron-specific enolase, NSE)和血清骨胶素(cytokeratin 19 fragments 21-1, CYFRA21-1),分析其诊断NSCLC的价值。结果 NSCLC组血浆中miR-34b-3p及miR-302a-5p表达水平明显高于PTB组和健康对照组(P<0.05)。血浆miR-34b-3p的表达水平与肿瘤直径相关(P<0.01)。单项检测NSCLC时,miR-302a-5p的灵敏度最高(82.6%),CEA的特异度最高(81.6%)。双项检测NSCLC时,miR-34b-3p+miR-302a-5p的灵敏度最高(80.2%),miR-34b-3p+CEA的特异度最高(89.3%)。多项检测NSCLC时,miR-302a-5p+NSE+CYFRA21-1的灵敏度最高(81.4%),miR-34b-3p+CEA+NSE的特异度最高(90.3%)。当联合miR-34b-3p、miR-302a-5p和CEA进行检测时,其ROC曲线下面积AUC(area under the curve, AUC)最大,为0.832。Logistic回归模型表明:在NSCLC与对照组(PTB组+健康对照组)中,miR-34b-3p可能是NSCLC发生的独立危险因素。结论血浆miR-34b-3p、miR-302a-5p有可能成为NSCLC辅助诊断的血浆学标志物。 展开更多
关键词 肺肿瘤 诊断 微小核糖核酸 肿瘤标志物
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液体活检在肺癌早期诊断中的研究进展 被引量:16
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作者 宋治鹏 刘洋 《中国肺癌杂志》 CAS CSCD 北大核心 2018年第8期620-627,共8页
肺癌的早期诊断有利于提高患者的生存率。应用影像学方法对肺癌高风险人群进行筛查,可以起到早发现、早诊断的作用。越来越多的研究显示,液体活检(liquid biopsy)可以对该方法进行替代和补充。检测肺癌患者外周血中的循环肿瘤细胞(circu... 肺癌的早期诊断有利于提高患者的生存率。应用影像学方法对肺癌高风险人群进行筛查,可以起到早发现、早诊断的作用。越来越多的研究显示,液体活检(liquid biopsy)可以对该方法进行替代和补充。检测肺癌患者外周血中的循环肿瘤细胞(circulating tumor cells,CTCs)、循环肿瘤DNA(circulating tumor DNA,ctDNA)、微小核糖核酸(microRNA,miRNA)、外泌体(exosomes)、肿瘤血小板(tumor educated platelets,TEPs)可以用于肺癌的早期诊断,并且可能为影像学检查阴性的高风险人群提供相应的诊疗建议。全文就以上标志物的检测手段、在肺癌早期诊断中的价值以及存在优势与局限性进行综述,以期促进液体活检在肺癌早期诊断、与其他筛查手段相结合方面的应用。 展开更多
关键词 肺肿瘤 液体活检 诊断 循环肿瘤细胞 循环肿瘤DNA 微小核糖核酸 外泌体 肿瘤血小板
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Epitaxial fabrication of two-dimensional TiTe_2 monolayer onAu(111) substrate with Te as buffer layer
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作者 zhipeng song Bao Lei +9 位作者 Yun Cao Jing Qi Hao Peng Qin Wang Li Huang Hongliang Lu Xiao Lin Ye-Liang Wang Shixuan Du Hong-Jun Gao 《Chinese Physics B》 SCIE EI CAS CSCD 2019年第5期16-19,共4页
Two-dimensional(2 D) materials provide a platform to exploit the novel physical properties of functional nanodevices.Here, we report on the formation of a new 2 D layered material, a well-ordered monolayer TiTe_2, on ... Two-dimensional(2 D) materials provide a platform to exploit the novel physical properties of functional nanodevices.Here, we report on the formation of a new 2 D layered material, a well-ordered monolayer TiTe_2, on a Au(111) surface by molecular beam epitaxy(MBE). Low-energy electron diffraction(LEED) measurements of the samples indicate that the TiTe_2 film forms(√3 ×√7) superlattice with respect to the Au(111) substrate, which has three different orientations. Scanning tunneling microscopy(STM) measurements clearly show three ordered domains consistent with the LEED patterns.Density functional theory(DFT) calculations further confirm the formation of 2 H-TiTe_2 monolayer on the Au(111) surface with Te as buffer layer. The fabrication of this 2 D layered heterostructure expands 2 D material database, which may bring new physical properties for future applications. 展开更多
关键词 TiTe2 EPITAXIAL FABRICATION SUPERLATTICE scanning tunneling microscopy (STM) LOW-ENERGY electron diffraction (LEED)
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基于温度开关的光响应智能水凝胶用于可逆信息加密和解密
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作者 狄睿 宋志鹏 +7 位作者 李明通 练梦洁 王毅桐 郭俊江 苗豪杰 袁腾跃 刘静 周建华 《Science China Materials》 SCIE EI CAS CSCD 2024年第7期2123-2134,共12页
在智能凝胶防伪系统中使用的光、热、电、pH等刺激响应性水凝胶,是一种有前途的信息加密和解密材料.然而单一刺激会限制高水平的防伪.因此,需要协同使用多种刺激来提升信息安全等级.本研究设计了一种高透明度的海藻酸钠-聚丙烯酰胺(SA-P... 在智能凝胶防伪系统中使用的光、热、电、pH等刺激响应性水凝胶,是一种有前途的信息加密和解密材料.然而单一刺激会限制高水平的防伪.因此,需要协同使用多种刺激来提升信息安全等级.本研究设计了一种高透明度的海藻酸钠-聚丙烯酰胺(SA-PAM)水凝胶作为基体,利用无机变色材料钼酸铵(Mo7)赋予其凝胶光致变色特性.此外,温敏材料聚N-异丙基丙烯酰胺(PNIPAM)可使凝胶在最低临界相变温度(LCST)下发生体积相变,进而改变凝胶的宏观状态,可以通过调整凝胶体系中亲水单体和疏水单体的比例来控制LCST.利用紫外线(UV)作为“墨水”输入信息,以温度作为“开关”来加密/解密信息.总之,该水凝胶具有出色的光致变色能力,可在10 s内着色,紫外光吸收率最高可达96.23%.利用水凝胶对光-热刺激展现出的非凡响应能力,可以实现其迅速显示和隐藏信息的功能,从而确保信息安全,这为光致变色水凝胶在信息加密领域的应用提供了一种新方法. 展开更多
关键词 stimulus-responsive hydrogel information storage information security
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Bionic Muscle Control with Adaptive Stiffness for Bionic Parallel Mechanism
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作者 Yaguang Zhu Ruyue Li zhipeng song 《Journal of Bionic Engineering》 SCIE EI CSCD 2023年第2期598-611,共14页
As the torso is critical to the coordinated movement and flexibility of vertebrates,a 6-(Degree of Freedom)DOF bionic parallel torso with noteworthy motion space was designed in our previous work.To improve the compli... As the torso is critical to the coordinated movement and flexibility of vertebrates,a 6-(Degree of Freedom)DOF bionic parallel torso with noteworthy motion space was designed in our previous work.To improve the compliance of the parallel mechanism,a pair of virtual muscle models is constructed on both sides of the rotating joints of each link of the mechanism,and a bionic muscle control algorithm is introduced.By analyzing the control parameters of the muscle model,dynamic characteristics similar to those of biological muscle are obtained.An adaptive stiffness control is proposed to adaptively adjust the stiffness coefficient with the change in the external load of the parallel mechanism.The attitude closed-loop control can effectively keep the attitude angle unchanged when the position of the moving platform changes.The simulations and experiments are undertaken to validate compliant movements and the flexibility and adaptability of the parallel mechanism. 展开更多
关键词 Bionic mechanism Compliance control Muscle model Stiffness adaptation Dura-rate integral learning
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Effects of irrigation level and method on soil salt balance and crop water use efficiency in arid oasis regions
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作者 Liping Tang Xueshuang Shi +2 位作者 zhipeng song Han Zhao Fahu Li 《International Journal of Agricultural and Biological Engineering》 SCIE 2023年第6期158-166,共9页
Fresh water resource scarcity and soil salt accumulation in the root-zone are two key limiting factors for sustainable agricultural development in the oasis region of arid inland basin, northwest China. The aim of thi... Fresh water resource scarcity and soil salt accumulation in the root-zone are two key limiting factors for sustainable agricultural development in the oasis region of arid inland basin, northwest China. The aim of this study was to explore an appropriate irrigation scheme to maintain sustainable crop cultivation in this region. The effects of four irrigation levels (full irrigation, mild deficit, moderate deficit, and severe deficit) and three irrigation methods (border, surface drip and subsurface drip) on soil water and salt dynamics, highland barley (Hordeum vulgare L.) yield, and crop water use efficiency were studied by field plot experiments. The results showed that soil salt in 0-100 cm profile was accumulated under all experimental treatments after one season of highland barley planting, but the accumulated salt mass decreased with the decrease of the lower limit of irrigation. Salt mass in 0-100 cm soil profile under subsurface drip irrigation was 16.8%-57.8% and 2.9%-58.4% less than that under border and surface drip irrigation, respectively. The grain yield of highland barley decreased first and then increased with the decrease of the lower limit of irrigation under surface drip and subsurface drip irrigation, but it was on the contrary under border irrigation. Mean grain yield for all irrigation levels under subsurface drip irrigation was 5.7% and 18.8% higher than that under border and surface drip irrigation, respectively. Water use efficiency increased with the decrease of the lower limit of irrigation, and the averaged water use efficiency of all irrigation levels under subsurface drip irrigation was 11.9% and 14.2% higher than that under border and surface drip irrigation, respectively. Considering economic benefit and irrigation water requirement, subsurface drip irrigation with the lower limit of irrigation of 50%-55% field capacity is suggested for highland barley planting in the arid oasis region. 展开更多
关键词 arid oasis highland barley irrigation method irrigation level soil salt balance water use efficiency
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Estimate pose deviation of on-orbit deployable mechanisms based on cross-ratio invariability
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作者 Peiran ZHANG Fuqiang ZHOU +2 位作者 zhipeng song Wentao GUO Haishu TAN 《Chinese Journal of Aeronautics》 SCIE EI CAS 2024年第10期483-492,共10页
With the rapid development of space science projects,large deployable mechanisms have been widely used.However,due to the effects of mechanical friction and gravitational acceleration,on-orbit mechanisms cannot be alw... With the rapid development of space science projects,large deployable mechanisms have been widely used.However,due to the effects of mechanical friction and gravitational acceleration,on-orbit mechanisms cannot be always deployed to the expected pose.For some precision optical mechanisms,even a minor deviation can result in significant error,so it needs to be measured and corrected.In this paper,the deployment process was modeled and simplified as rotation under single-rotation-axis constraint and translation under single-direction constraint.To solve the problem,a method based on cross-ratio invariability was proposed.The proposed method does not rely on camera calibration techniques,as well as artificial marking points,both of which are necessary in PnP.Instead,only three calibration images before launch and a measurement image on orbit were required.Simulations and experiments demonstrated that the proposed method is more accurate than PnP.In addition,experiments also proved that the feasibility of the proposed method under dark conditions with the aid of a light source and some reflective marking points. 展开更多
关键词 Cross-ratio invariability Deployable mechanism Pose deviation estimation Single-DOF constraint Vision measurement
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Inertial Motion Tracking on Mobile and Wearable Devices:Recent Advancements and Challenges 被引量:1
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作者 zhipeng song Zhichao Cao +2 位作者 Zhenjiang Li Jiliang Wang Yunhao Liu 《Tsinghua Science and Technology》 SCIE EI CAS CSCD 2021年第5期692-705,共14页
Motion tracking via Inertial Measurement Units(IMUs)on mobile and wearable devices has attracted significant interest in recent years.High-accuracy IMU-tracking can be applied in various applications,such as indoor na... Motion tracking via Inertial Measurement Units(IMUs)on mobile and wearable devices has attracted significant interest in recent years.High-accuracy IMU-tracking can be applied in various applications,such as indoor navigation,gesture recognition,text input,etc.Many efforts have been devoted to improving IMU-based motion tracking in the last two decades,from early calibration techniques on ships or airplanes,to recent arm motion models used on wearable smart devices.In this paper,we present a comprehensive survey on IMU-tracking techniques on mobile and wearable devices.We also reveal the key challenges in IMU-based motion tracking on mobile and wearable devices and possible directions to address these challenges. 展开更多
关键词 Inertial Measurement Units(IMUs) motion tracking ACCELEROMETER GYROSCOPE MAGNETOMETER sensor fusion
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Line defects in monolayer TiSe_(2) with adsorption of Pt atoms potentially enable excellent catalytic activity 被引量:1
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作者 zhipeng song Juxia Yi +18 位作者 Jing Qi Qi Zheng Zhili Zhu Lei Tao Yun Cao Yan Li Zhaoyan Gao Ruizi Zhang Li Huang Geng Li Ziqiang Xu Xu Wu Yeliang Wang Chengmin Shen Yu-Yang Zhang Hongliang Lu Xiao Lin Shixuan Du Hong-Jun Gao 《Nano Research》 SCIE EI CSCD 2022年第5期4687-4692,共6页
Two-dimensional(2D)materials with defects are desired for catalysis after the adsorption of monodispersed noble metal atoms.High-performance catalysts with the absolute value of Gibbs free energy(|△GH|)close to zero,... Two-dimensional(2D)materials with defects are desired for catalysis after the adsorption of monodispersed noble metal atoms.High-performance catalysts with the absolute value of Gibbs free energy(|△GH|)close to zero,is one of the ultimate goals in the catalytic field.Here,we report the formation of monolayer titanium selenide(TiSe2)with line defects.The low-temperature scanning tunneling microscopy/spectroscopy(STM/S)measurements revealed the structure and electronic states of the line defect.Density functional theory(DFT)calculation results confirmed that the line defects were induced by selenium vacancies and the STM simulation was in good agreement with the experimental results.Further,DFT calculations show that monolayer TiSe_(2) with line defects have good catalytic activity for hydrogen evolution reaction(HER).If the defects are decorated with single Pt atom,the HER catalytic activity will be enhanced dramatically(|△GH|=0.006 eV),which is much better than Pt metal(|△GH|=0.09 eV).Line defects in monolayer TiSe_(2)/Au(111)provide a wonderful platform for the design of high-performance catalysts. 展开更多
关键词 line defects hydrogen evolution reaction monolayer titanium selenide(TiSe_(2)) scanning tunneling microscope density functionaltheorycalculation
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