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子宫平滑肌肉瘤的分子遗传学特征与研究进展
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作者 王陈颖 肖荟尹 +3 位作者 诸志鹏 郑素雅 徐良 陈烨 《遗传》 CAS CSCD 北大核心 2024年第8期603-626,共24页
子宫平滑肌肉瘤(uterine leiomyosarcoma,uLMS)是一种发生在女性生殖系统子宫肌层的恶性软组织肿瘤,漏诊误诊率高、侵袭性强、预后差。uLMS的发生机制尚未明确,疾病生物学研究相对滞后,实验模型和治疗手段也较为有限。本文重点关注了uLM... 子宫平滑肌肉瘤(uterine leiomyosarcoma,uLMS)是一种发生在女性生殖系统子宫肌层的恶性软组织肿瘤,漏诊误诊率高、侵袭性强、预后差。uLMS的发生机制尚未明确,疾病生物学研究相对滞后,实验模型和治疗手段也较为有限。本文重点关注了uLMS的病理分子生物学,系统梳理了uLMS的分子遗传学特征、表观遗传学变异、实验模型以及临床研究进展,同时还探讨了uLMS在肿瘤演进、肿瘤微环境、肿瘤治疗等生物学研究领域的发展方向和潜在需求,以期更好地理解uLMS的病理生物学机制并为开发潜在诊疗策略提供参考。 展开更多
关键词 子宫平滑肌肉瘤 遗传变异 分子病理 肿瘤治疗 疾病模型
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CrossFormer Embedding DeepLabv3+ for Remote Sensing Images Semantic Segmentation
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作者 Qixiang Tong zhipeng zhu +2 位作者 Min Zhang Kerui Cao Haihua Xing 《Computers, Materials & Continua》 SCIE EI 2024年第4期1353-1375,共23页
High-resolution remote sensing image segmentation is a challenging task. In urban remote sensing, the presenceof occlusions and shadows often results in blurred or invisible object boundaries, thereby increasing the d... High-resolution remote sensing image segmentation is a challenging task. In urban remote sensing, the presenceof occlusions and shadows often results in blurred or invisible object boundaries, thereby increasing the difficultyof segmentation. In this paper, an improved network with a cross-region self-attention mechanism for multi-scalefeatures based onDeepLabv3+is designed to address the difficulties of small object segmentation and blurred targetedge segmentation. First,we use CrossFormer as the backbone feature extraction network to achieve the interactionbetween large- and small-scale features, and establish self-attention associations between features at both large andsmall scales to capture global contextual feature information. Next, an improved atrous spatial pyramid poolingmodule is introduced to establish multi-scale feature maps with large- and small-scale feature associations, andattention vectors are added in the channel direction to enable adaptive adjustment of multi-scale channel features.The proposed networkmodel is validated using the PotsdamandVaihingen datasets. The experimental results showthat, compared with existing techniques, the network model designed in this paper can extract and fuse multiscaleinformation, more clearly extract edge information and small-scale information, and segment boundariesmore smoothly. Experimental results on public datasets demonstrate the superiority of ourmethod compared withseveral state-of-the-art networks. 展开更多
关键词 Semantic segmentation remote sensing multiscale self-attention
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浅谈压舱水处理技术的进展 被引量:1
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作者 徐海洋 杜审言 +1 位作者 朱志鹏 孙明 《水污染及处理》 2015年第4期69-75,共7页
压舱水的排放会引发外来生物入侵等问题、破坏当地海洋生态环境,已受到世界范围的关注。本文简述目前实验室研究压舱水处理技术中两种可行的模拟压舱水的制备方法,并简要回顾已有的压舱水处理方法。介绍了放电等离子体水处理技术,总结... 压舱水的排放会引发外来生物入侵等问题、破坏当地海洋生态环境,已受到世界范围的关注。本文简述目前实验室研究压舱水处理技术中两种可行的模拟压舱水的制备方法,并简要回顾已有的压舱水处理方法。介绍了放电等离子体水处理技术,总结了气液两相混合脉冲放电等离子体水处理的影响因素,以及其用于压舱水处理的研究进展。 展开更多
关键词 模拟压舱水 放电等离子体 气液两相 影响因素 水处理技术
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脉冲放电等离子体灭菌技术及其研究进展
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作者 杜审言 王红岩 +2 位作者 朱志鹏 徐海洋 孙明 《水污染及处理》 2015年第3期61-68,共8页
脉冲放电等离子体灭菌技术是一种利用电压瞬间发生变化而对细菌产生不可逆损失,进而导致其死亡的一种非热灭菌技术。论文综述了脉冲放电等离子体的灭菌机理、特点以及其在国内外应用的研究进展,总结了现有脉冲放电等离子体灭菌技术研究... 脉冲放电等离子体灭菌技术是一种利用电压瞬间发生变化而对细菌产生不可逆损失,进而导致其死亡的一种非热灭菌技术。论文综述了脉冲放电等离子体的灭菌机理、特点以及其在国内外应用的研究进展,总结了现有脉冲放电等离子体灭菌技术研究热点,提出了脉冲放电等离子体灭菌技术的后续研究工作和展望。 展开更多
关键词 灭菌 脉冲放电 等离子体 大肠杆菌
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Spectroscopic diagnosis of plasma in atmospheric pressure negative pulsed gas-liquid discharge with nozzle-cylinder electrode
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作者 Ming SUN Zhan TAO +2 位作者 zhipeng zhu Dong WANG Wenjun PAN 《Plasma Science and Technology》 SCIE EI CAS CSCD 2018年第5期30-35,共6页
The plasma characteristics of a gas-liquid phase discharge reactor were investigated by optical and electrical methods.The nozzle-cylinder electrode in the discharge reactor was supplied witha negative nanosecond puls... The plasma characteristics of a gas-liquid phase discharge reactor were investigated by optical and electrical methods.The nozzle-cylinder electrode in the discharge reactor was supplied witha negative nanosecond pulsed generator.The optical emission spectrum diagnosis revealed that OH(A2∑+ → X2Π,306–309 nm),N32(CΠ→B3Πg,337 nm),O(3p5p→3s-5s-0,777.2 nm)and O(3p3p→3s3s0,844.6 nm)were produced in the discharge plasma channels.The electron temperature(Te)was calculated from the emission relative intensity ratio between the atomic O 777.2 nm and 844.6 nm,and it increased with the applied voltage and the pulsed frequency and fell within the range of 0.5–0.8 e V.The gas temperature(Tg)that was measured by Lifbase was in a range from 400 K to 600 K. 展开更多
关键词 gas-liquid negative pulsed discharge discharge plasma reactivate species nozzle-cylinder electrode DIAGNOSIS
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Industrialization Emission (Trace Metal, Nitrogen and Phosphorus) Modified Coastal Climate
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作者 Yongpeng Tong zhipeng zhu 《Journal of Geoscience and Environment Protection》 2015年第6期1-5,共5页
Objectives: As a result of global warming, precipitation is likely to increase at certain area (high latitudes). However, the mechanisms that human activity is influenced by global climate change are far from complete... Objectives: As a result of global warming, precipitation is likely to increase at certain area (high latitudes). However, the mechanisms that human activity is influenced by global climate change are far from completely understood. We try to analyze the relationship between industrial emission (trace metal, nitrogen and phosphorus) and climate signature (precipitation) by Chinese industrialization progresses. Methods: Mainly by using the public data from Bulletin of Environment in China, Bulletin of Marine Environmental Status of China and some data of our experiments, we get the analyzed result. Results: Annual average temperature in China after industrialization is significantly increased, whereas annual average precipitation in China after industrialization is no significantly difference. Phytoplankton increases evaporation of seawater and the relative humidity. Phytoplankton biomass will be different in different stages of environmental pollution in coastal areas. The higher relative humidity of Guangzhou (near the second-third class pollution coast-Shenzhen coast with higher phytoplankton biomass) has higher precipitation;in contrast, lower relative humidity of Shanghai (near the inferior fouth class Zhejiang coast) has lower precipitation recent years. Conclusions: Industrial emissions may have two competing effects: one is to promote the growth of phytoplankton and then cause higher seawater evaporation rates and precipitation;another is to decrease water vapour pressure by serious pollution, which then reduces the seawater evaporation rate and precipitation. With temperature increasing, the precipitation is likely to increase only at low pollution area (high latitudes). 展开更多
关键词 Industrial EMISSION PHYTOPLANKTON Biomass CLIMATE SIGNATURE
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Innovative insights into extrachromosomal circular DNAs in gynecologic tumors and reproduction
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作者 Ning Wu Ling Wei +5 位作者 zhipeng zhu Qiang Liu Kailong Li Fengbiao Mao Jie Qiao Xiaolu Zhao 《Protein & Cell》 SCIE CSCD 2024年第1期6-20,共15页
Originating but free from chromosomal DNA,extrachromosomal circular DNAs(eccDNAs)are organized in circular form and have long been found in unicellular and multicellular eukaryotes.Their biogenesis and function are po... Originating but free from chromosomal DNA,extrachromosomal circular DNAs(eccDNAs)are organized in circular form and have long been found in unicellular and multicellular eukaryotes.Their biogenesis and function are poorly understood as they are characterized by sequence homology with linear DNA,for which few detection methods are available.Recent advances in high-throughput sequencing technologies have revealed that eccDNAs play crucial roles in tumor formation,evolution,and drug resistance as well as aging,genomic diversity,and other biological processes,bringing it back to the research hotspot.Several mechanisms of eccDNA formation have been proposed,including the breakage-fusion-bridge(BFB)and translocation-deletion-amplification models.Gynecologic tumors and disorders of embryonic and fetal development are major threats to human reproductive health.The roles of eccDNAs in these pathological processes have been partially elucidated since the first discovery of eccDNA in pig sperm and the double minutes in ovarian cancer ascites.The present review summarized the research history,biogenesis,and currently available detection and analytical methods for eccDNAs and clarified their functions in gynecologic tumors and reproduction.We also proposed the application of eccDNAs as drug targets and liquid biopsy markers for prenatal diagnosis and the early detection,prognosis,and treatment of gynecologic tumors.This review lays theoretical foundations for future investigations into the complex regulatory networks of eccDNAs in vital physiological and pathological processes. 展开更多
关键词 extrachromosomal circular DNAs gynecologic tumors REPRODUCTION liquid biopsy non-invasive prena-tal testing
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