Wang Jinhua,a teacher and delegate to the19th CPC National Congress,lectures her rural students on law and morals in Hainan in November.She was selected as a delegate because of her creative style and dedication to ch...Wang Jinhua,a teacher and delegate to the19th CPC National Congress,lectures her rural students on law and morals in Hainan in November.She was selected as a delegate because of her creative style and dedication to children.Rowing boats for her students was the most memorable thing of her 38 years of teaching,said Wang Jinhua,a mountain schoolteacher on western Hainan island.展开更多
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase (RTK) that links extracellular signals to the control of cell survival, growth, proliferation and differentiation. EGFR has been a therapeutic ...The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase (RTK) that links extracellular signals to the control of cell survival, growth, proliferation and differentiation. EGFR has been a therapeutic target for human malignancies, due to its frequent hyperactivation, therefore, it is necessary to investigate the characteristics of EGFR mutation, and identify patients who are likely to benefit from EGFR mutation. In this study, we examined 766 non-small cell lung cancer (NSCLC) patients (675 tissue, 83 thoracic water precipitation and 8 plasma samples) tested in pathology department of First Affiliated Hospital of Xinjiang Medical University from 2013 to 2017 by using ARMS-PCR method. The correlation between EGFR mutations and clinical pathological features was further explored. Subgroup analyses according to ethnicity, histological type, sample type, and tumour grade were done. Subgroup analyses showed the mutation rate of tumor tissue, thoracic water precipitation and plasm was 30.5%, 37.3%, 50.0% respectively. We found female (p < 0.0001), no smoking (p < 0.001), adenocarcinoma (p < 0.0001), and tissue specimens (Tobacco use) were associated with higher EGFR mutation rate. The most common mutations were exon 19 deletions (47.30%) and L858R point (42.32%) mutation. We have not found any differences between EGFR mutations and ethnic groups especially. In addition, we did not find differences in common mutations and rare sensitive mutations in the survival of targeted therapies.展开更多
目的:探讨侵袭性B细胞淋巴瘤在PI3K/Akt/mTOR信号通路中PIK3CA与10号染色体上缺失的磷酸酶和张力蛋白同源物(phosphate and tension homology deleted on chromsome ten,PTEN)的表达情况及其与各临床病理指标的相关性。方法:回顾性分析...目的:探讨侵袭性B细胞淋巴瘤在PI3K/Akt/mTOR信号通路中PIK3CA与10号染色体上缺失的磷酸酶和张力蛋白同源物(phosphate and tension homology deleted on chromsome ten,PTEN)的表达情况及其与各临床病理指标的相关性。方法:回顾性分析新疆医科大学第一附属医院2008年1月至2012年12月术前未经任何治疗的侵袭性B细胞淋巴瘤标本235例,其中包括弥漫大B细胞淋巴瘤(diffuse large B-cell lymphoma,DLBCL)205例,伯基特淋巴瘤(Burkitt lymphoma,BL)27例,灰区淋巴瘤(介于DLBCL和BL之间,不能分类的B细胞淋巴瘤)3例。应用荧光原位杂交技术检测所有样本PIK3CA和PTEN基因的表达情况,统计分析其与各临床病理指标及预后的关系。结果:PIK3CA在侵袭性B细胞淋巴瘤中扩增率为12.3%(29/235),临床分期Ⅰ~Ⅱ期和Ⅲ~Ⅳ期的阳性率分别为8.6%(12/139)和17.7%(17/96),差异具有统计学意义(P=0.038)。PTEN在侵袭性B细胞淋巴瘤中的缺失率为13.6%(32/235),与其他临床病理特征无相关性。PIK3CA扩增和PTEN缺失呈负相关(P=0.046)。未发现PIK3CA扩增和PTEN缺失与生存期存在相关性。结论:PIK3CA扩增与侵袭性B细胞淋巴瘤疾病晚期相关,PIK3CA扩增和PTEN缺失在侵袭性B细胞淋巴瘤的发生中起促进作用。展开更多
文摘Wang Jinhua,a teacher and delegate to the19th CPC National Congress,lectures her rural students on law and morals in Hainan in November.She was selected as a delegate because of her creative style and dedication to children.Rowing boats for her students was the most memorable thing of her 38 years of teaching,said Wang Jinhua,a mountain schoolteacher on western Hainan island.
文摘The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase (RTK) that links extracellular signals to the control of cell survival, growth, proliferation and differentiation. EGFR has been a therapeutic target for human malignancies, due to its frequent hyperactivation, therefore, it is necessary to investigate the characteristics of EGFR mutation, and identify patients who are likely to benefit from EGFR mutation. In this study, we examined 766 non-small cell lung cancer (NSCLC) patients (675 tissue, 83 thoracic water precipitation and 8 plasma samples) tested in pathology department of First Affiliated Hospital of Xinjiang Medical University from 2013 to 2017 by using ARMS-PCR method. The correlation between EGFR mutations and clinical pathological features was further explored. Subgroup analyses according to ethnicity, histological type, sample type, and tumour grade were done. Subgroup analyses showed the mutation rate of tumor tissue, thoracic water precipitation and plasm was 30.5%, 37.3%, 50.0% respectively. We found female (p < 0.0001), no smoking (p < 0.001), adenocarcinoma (p < 0.0001), and tissue specimens (Tobacco use) were associated with higher EGFR mutation rate. The most common mutations were exon 19 deletions (47.30%) and L858R point (42.32%) mutation. We have not found any differences between EGFR mutations and ethnic groups especially. In addition, we did not find differences in common mutations and rare sensitive mutations in the survival of targeted therapies.
文摘目的:探讨侵袭性B细胞淋巴瘤在PI3K/Akt/mTOR信号通路中PIK3CA与10号染色体上缺失的磷酸酶和张力蛋白同源物(phosphate and tension homology deleted on chromsome ten,PTEN)的表达情况及其与各临床病理指标的相关性。方法:回顾性分析新疆医科大学第一附属医院2008年1月至2012年12月术前未经任何治疗的侵袭性B细胞淋巴瘤标本235例,其中包括弥漫大B细胞淋巴瘤(diffuse large B-cell lymphoma,DLBCL)205例,伯基特淋巴瘤(Burkitt lymphoma,BL)27例,灰区淋巴瘤(介于DLBCL和BL之间,不能分类的B细胞淋巴瘤)3例。应用荧光原位杂交技术检测所有样本PIK3CA和PTEN基因的表达情况,统计分析其与各临床病理指标及预后的关系。结果:PIK3CA在侵袭性B细胞淋巴瘤中扩增率为12.3%(29/235),临床分期Ⅰ~Ⅱ期和Ⅲ~Ⅳ期的阳性率分别为8.6%(12/139)和17.7%(17/96),差异具有统计学意义(P=0.038)。PTEN在侵袭性B细胞淋巴瘤中的缺失率为13.6%(32/235),与其他临床病理特征无相关性。PIK3CA扩增和PTEN缺失呈负相关(P=0.046)。未发现PIK3CA扩增和PTEN缺失与生存期存在相关性。结论:PIK3CA扩增与侵袭性B细胞淋巴瘤疾病晚期相关,PIK3CA扩增和PTEN缺失在侵袭性B细胞淋巴瘤的发生中起促进作用。
